Accelerated phase Ia/b evaluation of the malaria vaccine candidate PfAMA1 DiCo demonstrates broadening of humoral immune responses

Autor: Edmond J. Remarque, Bart W. Faber, Roberto Rodriguez Garcia, Herman Oostermeijer, Sodiomon B. Sirima, Issa Nebie Ouedraogo, Leila Kara, Odile Launay, Sophie Houard, Odile Leroy, Clemens H. M. Kocken

Publikováno v: npj Vaccines, Vol 6, Iss 1, Pp 1-11 (2021)

Abstract Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a candidate malaria vaccine antigen expressed on merozoites and sporozoites. PfAMA1’s polymorphic nature impacts vaccine-induced protection. To address polymorphism, three Diversi

Externí odkaz: https://doaj.org/article/e1524004d78d492694c5cb74ad9afcd8

Pandemic Swine-Origin H1N1 Influenza Virus Replicates to Higher Levels and Induces More Fever and Acute Inflammatory Cytokines in Cynomolgus versus Rhesus Monkeys and Can Replicate in Common Marmosets.

Autor: Petra Mooij, Gerrit Koopman, Daniëlla Mortier, Melanie van Heteren, Herman Oostermeijer, Zahra Fagrouch, Rudy de Laat, Gary Kobinger, Yan Li, Edmond J Remarque, Ivanela Kondova, Ernst J Verschoor, Willy M J M Bogers

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0126132 (2015)

The close immunological and physiological resemblance with humans makes non-human primates a valuable model for studying influenza virus pathogenesis and immunity and vaccine efficacy against infection. Although both cynomolgus and rhesus macaques ar

Externí odkaz: https://doaj.org/article/1787df5f7d4a436eb40a003f81878bd0

The post-acute phase of SARS-CoV-2 infection in two macaques species is associated with signs of ongoing virus replication and pathology in pulmonary and extrapulmonary tissues

Autor: Ronald E. Bontrop, Herman Oostermeijer, E. J. Remarque, Ernst J. Verschoor, Ella A. Zuiderwijk-Sick, Gerrit Koopman, Petra Mooij, Roja Fidel Acar, Nikki van Driel, Deborah Adema, Boudewijn Ouwerling, Patricia Sastre, Ivonne G. Nieuwenhuis, Daniella Mortier, Babs E. Verstrepen, Bart L. Haagmans, Alexis C. R. Hoste, Tom Haaksma, Willy M. J. M. Bogers, Gwendoline Kiemenyi-Kayere, Zahra Fagrouch, Ivanela Kondova, Lisette Meijer, Marieke A. Stammes, Jan A.M. Langermans, Richard A. W. Vervenne, Kinga P. Böszörményi, Henk Niphuis

The post-acute phase of SARS-CoV-2 infection was investigated in rhesus macaques (Macaca mulatta) and cynomolgus macaques (Macaca fascicularis). During the acute phase of infection, SARS-CoV-2 was shed via nose and throat, and viral RNA was occasiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b523dfc29189dc8c983f9f21f650e2d
https://doi.org/10.1101/2020.11.05.369413

Increased, Durable B-Cell and ADCC Responses Associated with T-Helper Cell Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site

Autor: Petra Mooij, Willy M. J. M. Bogers, Daniella Mortier, Niels Beenhakker, Herman Oostermeijer, Rachel P. J. Lai, Indresh K. Srivastava, David C. Montefiori, Brian Burke, David Davis, Grégoire Martin, Susan W. Barnett, Gerrit Koopman, Ivonne G. Nieuwenhuis, Edmund Remarque, Antu K. Dey, Guido Ferrari, Jonathan L. Heeney, Loïc Martin, Yide Sun

Publikováno v: Journal of Virology
Journal of Virology, 2017, 91 (19), ⟨10.1128/JVI.00811-17⟩
Journal of Virology, American Society for Microbiology, 2017, 91 (19), ⟨10.1128/JVI.00811-17⟩

Strategies are needed to improve the immunogenicity of HIV-1 envelope (Env) antigens (Ag) for more long-lived, efficacious HIV-1 vaccine-induced B-cell responses. HIV-1 Env gp140 (native or uncleaved molecules) or gp120 monomeric proteins elicit rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e6eca4cbe5a5e057ade9ae4e66e275
https://doi.org/10.1128/jvi.00811-17

Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus

Autor: Herman Oostermeijer, Marina De Filette, Michael S. Diamond, Babs E. Verstrepen, Niek N. Sanders, Linda Stertman, Henk Niphuis, Luisa Barzon, Stefan Chabierski, Willy M. J. M. Bogers, Tom Haaksma, Melanie van Heteren, Sebastian Ulbert, Ernst J. Verschoor, Ivanela Kondova, Zahra Fagrouch, Sofia E. Magnusson, Giorgio Palù, Julianna Lisziewicz, Orsolya Lőrincz

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e112568 (2014)
PLOS ONE
PLoS ONE

The mosquito-borne West Nile virus (WNV) causes human and animal disease with outbreaks in several parts of the world including North America, the Mediterranean countries, Central and East Europe, the Middle East, and Africa. Particularly in elderly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a63ac9954f29221dbae467d91d1c71b
http://europepmc.org/articles/PMC4231036?pdf=render