Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Herman Kwansa"'
Autor:
Jian Zhang, Herman Kwansa, Yun Tai Kim, Shaida A. Andrabi, Xiaoling Li, Liye Yi, Zeng Jin Yang, Raymond C. Koehler, Valina L. Dawson, Gina Hong, Ted M. Dawson
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 37:1982-1993
Tissue acidosis is a key component of cerebral ischemic injury, but its influence on cell death signaling pathways is not well defined. One such pathway is parthanatos, in which oxidative damage to DNA results in activation of poly(ADP-ribose) polyme
Autor:
Zeng Jin Yang, Daina Crafa, Raymond C. Koehler, David R. Harder, Erin L. Carter, Kathleen K. Kibler, Lee J. Martin, Herman Kwansa, Richard J. Roman
Publikováno v:
Journal of Neurochemistry. 121:168-179
20-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450 metabolite of arachidonic acid that that contributes to infarct size following focal cerebral ischemia. However, little is known about the role of 20-HETE in global cerebral ischemia or n
Autor:
Raymond C. Koehler, David R. Harder, Liang Chao Wang, Herman Kwansa, Suyi Cao, Richard J. Roman
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 296:R1412-R1418
Partial exchange transfusion with a cell-free hemoglobin (Hb) polymer during transient middle cerebral artery occlusion (MCAO) reduces infarct volume but fails to increase blood flow, as might be expected with the induced decrease in hematocrit. In i
Autor:
Toshiaki Mito, Enrico Bucci, Murtuza Habeeb, Raymond C. Koehler, Stephanie J. Murphy, Kenji Sampei, Masaaki Nemoto, Herman Kwansa
Publikováno v:
Stroke. 40:278-284
Background and Purpose— Transfusion of large polymers of hemoglobin avoids the peripheral extravasation and hypertension associated with crosslinked tetrameric hemoglobin transfusion and may be more effective in rescuing brain from focal ischemia.
Autor:
Darren Boehning, Sylvain Doré, Herman Kwansa, Raymond C. Koehler, Enrico Bucci, David Shugar, Xinyue Qin
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295:R498-R504
Carbon monoxide derived from heme oxygenase (HO) may participate in cerebrovascular regulation under specific circumstances. Previous work has shown that HO contributes to feline pial arteriolar dilation to acetylcholine after transfusion of a cell-f
Publikováno v:
Artificial Cells, Blood Substitutes, and Biotechnology. 35:11-18
Intramolecular crosslink of hemoglobin tetramers solved the problem of urine elimination and short intravascular retention time of cell free hemoglobin infusion. It also produced a family of crosslinked hemoglobins with P50 between 18 and 30 mmHg. Ho
Autor:
Yoshio Asano, Kenji Sampei, Enrico Bucci, John A. Ulatowski, Raymond C. Koehler, Herman Kwansa
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 289:H1191-H1201
Modified Hb solutions have been developed as O2 carrier transfusion fluids, but of concern is the possibility that increased scavenging of nitric oxide (NO) within the plasma will alter vascular reactivity even if the Hb does not readily extravasate.
Publikováno v:
Journal of Applied Physiology. 93:1479-1486
The clinical utility of cross-linked tetrameric hemoglobin solutions is limited by peripheral vasoconstriction thought to be due to scavenging of nitric oxide. In addition, transfusion of crude preparations of hemoglobin polymers can cause arterial h
Publikováno v:
Biopolymers. 63:1-11
We used static and dynamic light scattering for comparing the mass (MW) and hydrodynamic radius (R(h)) of several hemoglobin systems, namely human hemoglobin, bovine hemoglobin, human hemoglobin cross-linked with a sebacyl residue, and bovine hemoglo
Publikováno v:
Proteins: Structure, Function, and Genetics. 39:166-169
As indicated by peptide analyses and mass spectrometry estimations, intramolecular crosslink with bis(3,5-dibromosalicyl)adipate of bovine hemoglobin results in the formation of two main components covalently bridged across the beta-cleft. In one com