Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Herman J.M. van Rijn"'
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 25:867-872
Objective— Because of the large variation in oxidizing procedures and susceptibility to oxidation of low-density lipoprotein (LDL) and the lack in quantification of LDL oxidation, the role of oxidation in LDL–platelet contact has remained elusive
Autor:
Herman J.M. van Rijn, Jan-Willem N. Akkerman, Ingrid A.M. Relou, Gertie Gorter, Irlando Andrade Ferreira
Publikováno v:
Journal of Biological Chemistry. 278:32638-32644
At physiological concentrations, low density lipoprotein (LDL) increases the sensitivity of platelets to aggregation- and secretion-inducing agents without acting as an independent activator of platelet functions. LDL sensitizes platelets by inducing
Publikováno v:
Biochemical Journal. 369:407-416
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase implicated in signalling pathways mediated by integrins and G-protein-coupled receptors (GPCRs). Upon stimulation FAK is phosphorylated on six tyrosine residues. Here we report the site-sp
Autor:
Christian M. Hackeng, Ingrid A.M. Relou, Gertie Gorter, Marc W. Pladet, Jan-Willem N. Akkerman, Herman J.M. van Rijn
Publikováno v:
Thrombosis and Haemostasis. 82:1749-1756
SummaryLow Density Lipoprotein (LDL) is known to sensitize platelets for physiological agonists. To clarify the basis of this sensitization, we investigated the involvement of p38MAP Kinase (p38MAPK). As dual phosphorylation on Thr180 and Tyr182 of p
Publikováno v:
Journal of Biological Chemistry. 274:384-388
Low density lipoprotein (LDL) is known to sensitize platelets to agonists via integrin mediated outside-in signaling (Hackeng, C. M., Huigsloot, M., Pladet, M. W., Nieuwenhuis, H. K., Rijn, H. J. M. v., and Akkerman, J. W. N. (1999) Arterioscler. Thr
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1303:15-21
Increased plasma concentrations of lipoprotein(a) (Lp(a)) are associated with an increased risk for atherosclerotic cardiovascular disease. It is thought that the atherogenicity of Lp(a) is mediated both through its LDL-like properties and its plasmi
Autor:
Ellen Meyer, Rienk Rienks, D. Willem Erkelens, Marleen M.J. van Greevenbroek, Herman J.M. van Rijn, H. Tineke Westerveld, Tjerk W.A. de Bruin, Florianne C. de Ruyter-Meijstek
Publikováno v:
Atherosclerosis. 124:221-235
Because remnants of triglyceride-rich lipoproteins (TRLP) are potentially atherogenic, the postprandial lipoprotein metabolism was studied in 12 normocholesterolemic, normotriglyceridemic women, aged 60 ± 2 years, with angiographically proven corona
Publikováno v:
Clinical Biochemistry. 27:449-455
Three commercially available assays (an enzyme-linked immunosorbent assay ELISA, an immunoradiometric assay, IRMA, and a nephelometric assay) for the determination of lipoprotein(a) [Lp(a)] were compared with respect to the dependency of these assays
Autor:
J. Marko Sikkema, Hein W. Bruinse, Bas B. van Rijn, Herman J.M. van Rijn, Arie Franx, Hieronymus A.M. Voorbij
Publikováno v:
Hypertension in pregnancy. 27(2)
Ischemia-modified albumin (IMA) has emerged as a new biomarker of myocardial ischemia. Currently, no information is available on maternal IMA levels during normal and complicated pregnancy. Preeclampsia is associated with ischemia and increased forma
Autor:
George A. Kaysen, Berthil H.C.M.T. Prinsen, Frans Stellaard, Monique G.M. de Sain-van der Velden, Ton J. Rabelink, Herman J.M. van Rijn, Helma W. H. C. Straver, Ruud Berger
Publikováno v:
Journal of the American Society of Nephrology : JASN. 12(5)
The urinary loss of transferrin is sufficient to reduce plasma transferrin concentrations in the nephrotic syndrome. Hypotransferrinemia may lead to iron loss and microcytic anemia. The mechanism responsible for the hypotransferrinemia in the nephrot