Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Herman H. W. Silljé"'
Autor:
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Belend Mahmoud, Albert Gerding, Justina C. Wolters, Anouk H. G. Wolters, Ben N. G. Giepmans, Herman H. W. Silljé, Rudolf A. de Boer, Barbara M. Bakker, B. Daan Westenbrink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes mitochondrial respiration and attenuates mitochondrial oxidative stress in cultured cardiomyocytes. We sought to determine whether AKIP1 influences mitochondrial fu
Externí odkaz:
https://doaj.org/article/0f6febf0dad84f44a4fe25e6b176abbe
Autor:
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Harmen G. Booij, Silke U. Oberdorf-Maass, Martin M. Dokter, Anouk H. G. Wolters, Ben N. G. Giepmans, Wiek H. van Gilst, Joan H. Brown, Rudolf A. de Boer, Herman H. W. Silljé, B. Daan Westenbrink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes physiological hypertrophy in vitro. The purpose of this study is to determine if AKIP1 promotes physiological cardiomyocyte hypertrophy in vivo. Therefore, adult ma
Externí odkaz:
https://doaj.org/article/ed562cee66ed427ca8cecb89312bca87
Autor:
Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ische
Externí odkaz:
https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344
Autor:
Arnold Piek, Leonie Smit, Navin Suthahar, Stephan J. L. Bakker, Rudolf A. de Boer, Herman H. W. Silljé
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract Dickkopf-3 (DKK3) is an emerging biomarker for cardiovascular disease (CVD) and chronic kidney disease (CKD). Herein, baseline DKK3 plasma levels were measured in 8420 subjects from the Prevention of Renal and Vascular ENd-stage Disease (PRE
Externí odkaz:
https://doaj.org/article/de60494287fb41dbba247de069f29ab7
Autor:
Salva R. Yurista, Herman H. W. Silljé, Michiel Rienstra, Rudolf A. de Boer, B. Daan Westenbrink
Publikováno v:
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-7 (2020)
Abstract While patients with type 2 diabetes mellitus (T2DM) are at increased risk to develop atrial fibrillation (AF), the mechanistic link between T2DM and AF-susceptibility remains unclear. Common co-morbidities of T2DM, particularly hypertension,
Externí odkaz:
https://doaj.org/article/f5980cffc9ce4acea7ab328783ae6874
Autor:
Mathilde C. S. C. Vermeer, Daniela Andrei, Luisa Marsili, J. Peter van Tintelen, Herman H. W. Silljé, Maarten P. van den Berg, Peter van der Meer, Maria C. Bolling
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10765 (2022)
Genetic variants in gene-encoding proteins involved in cell–cell connecting structures, such as desmosomes and gap junctions, may cause a skin and/or cardiac phenotype, of which the combination is called cardiocutaneous syndrome. The cardiac phenot
Externí odkaz:
https://doaj.org/article/fff995654c4f4d3cb850ab8b35b514f5
Autor:
Tim R. Eijgenraam, Nienke M. Stege, Vivian Oliveira Nunes Teixeira, Remco de Brouwer, Elisabeth M. Schouten, Niels Grote Beverborg, Liu Sun, Daniela Später, Ralph Knöll, Kenny M. Hansson, Carl Amilon, David Janzén, Steve T. Yeh, Adam E. Mullick, Peter van der Meer, Rudolf A. de Boer, Herman H. W. Silljé
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 5, p 2427 (2022)
Inherited cardiomyopathy caused by the p.(Arg14del) pathogenic variant of the phospholamban (PLN) gene is characterized by intracardiomyocyte PLN aggregation and can lead to severe dilated cardiomyopathy. We recently reported that pre-emptive depleti
Externí odkaz:
https://doaj.org/article/274ea8908b314273afba42785d996baf
Autor:
Anne‐Marie C. Koop, Guido P. L. Bossers, Mark‐Jan Ploegstra, Quint A. J. Hagdorn, Rolf M. F. Berger, Herman H. W. Silljé, Beatrijs Bartelds
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 21 (2019)
Background Right ventricular (RV) failure because of chronic pressure load is an important determinant of outcome in pulmonary hypertension. Progression towards RV failure is characterized by diastolic dysfunction, fibrosis and metabolic dysregulatio
Externí odkaz:
https://doaj.org/article/cbe97ece7971434b9af7d9df7a8c2354
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 2955 (2021)
For patients with hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM) or arrhythmogenic cardiomyopathy (ACM), screening for pathogenic variants has become standard clinical practice. Genetic cascade screening also allows the identificatio
Externí odkaz:
https://doaj.org/article/7238a14de00d4554b9148a2f6fa50d8c
Autor:
Guido P. L. Bossers, Quint A. J. Hagdorn, Anne-Marie C. Koop, Diederik E. van der Feen, B. Bartelds, Tom van Leusden, Rudolf A. De Boer, Herman H. W. Silljé, Rolf M. F. Berger
Publikováno v:
American journal of physiology. Heart and circulatory physiology, 322(6), H994-H1002. American Physiological Society
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(6), H994-H1002. AMER PHYSIOLOGICAL SOC
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 322(6), H994-H1002. AMER PHYSIOLOGICAL SOC
Sex is increasingly emerging as determinant of right ventricular (RV) adaptation to abnormal loading conditions. It is unknown, however, whether sex-related differences already occur in childhood. Therefore, this study aimed to assess sex differences