Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Herman H, Cheung"'
Supplementary Figures 1-6, Tables 1-2, Methods from Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6ab4a0b56d118c89c6b49d0c42e809
https://doi.org/10.1158/0008-5472.22382655.v1
https://doi.org/10.1158/0008-5472.22382655.v1
Smac mimetic compounds (SMC) are novel small molecules being developed for cancer therapy. The mechanism of SMC-induced sensitivity in cancer cells depends on autocrine release of tumor necrosis factor α (TNFα); however, potential mechanisms of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a8107ee8c237bb511bc3de5b9f1e38c
https://doi.org/10.1158/0008-5472.c.6500274
https://doi.org/10.1158/0008-5472.c.6500274
Autor:
Robert G. Korneluk, Herman H. Cheung, Stephen Baird, Martine St-Jean, Eric C. LaCasse, Caroline E. Beauregard, Tarun Sanda, Shawn Beug, Hapsatou Mamady
Publikováno v:
Science Signaling. 12
The controlled production and downstream signaling of the inflammatory cytokine tumor necrosis factor-α (TNF-α) are important for immunity and its anticancer effects. Although chronic stimulation with TNF-α is detrimental to the health of the host
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd83b12a9ea70ccf81bcba205d600446
https://doi.org/10.1126/scisignal.aat9563
https://doi.org/10.1126/scisignal.aat9563
Autor:
Eric C. LaCasse, Shawn T. Beug, Vera A. Tang, Herman H. Cheung, Jan Brun, Douglas J. Mahoney, Carolina S. Ilkow, Robert G. Korneluk, John C. Bell, Caroline E. Beauregard, Jeffrey P Nuyens, Martine St-Jean, Himika Dastidar, Nathalie Earl, Janelle Holbrook, Fabrice Le Boeuf
Publikováno v:
Nature biotechnology
Smac mimetic compounds (SMC), a class of drugs that sensitize cells to apoptosis by counteracting the activity of inhibitor of apoptosis (IAP) proteins, have proven safe in phase 1 clinical trials in cancer patients. However, because SMCs act by enab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9177fd5821da866031981196c381ce2d
https://doi.org/10.1038/nbt.2806
https://doi.org/10.1038/nbt.2806
Publikováno v:
Trends in Immunology. 33:535-545
The inhibitor of apoptosis (IAP) genes are critical regulators of multiple pathways that control cell death, proliferation, and differentiation. Several members of the IAP family regulate innate and adaptive immunity through modulation of signal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bf30221782f2457f4056a55be7992b
https://doi.org/10.1016/j.it.2012.06.004
https://doi.org/10.1016/j.it.2012.06.004
Autor:
Robert G. Korneluk, Herman H. Cheung, Brian Zarnegar, Douglas J. Mahoney, Tak W. Mak, Xiaolu Yang, Paul W. Dempsey, Yaya Wang, Genhong Cheng, Wen-chen Yeh, Travis L. Shiba, Jeannie He
Publikováno v:
Nature immunology
Recent studies suggest that nuclear factor kappaB-inducing kinase (NIK) is suppressed through constitutive proteasome-mediated degradation regulated by TRAF2, TRAF3 and cIAP1 or cIAP2. Here we demonstrated that the degradation of NIK occurs upon asse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db614fff5c3e115addd03dd9255f62f5
https://doi.org/10.1038/ni.1676
https://doi.org/10.1038/ni.1676
Autor:
Benjamin Jung, Warren Ho, James W. Gurd, M. Christopher Wallace, Denis G.M. Jugloff, James H. Eubanks, Guangming Zhang, Herman H. Cheung
Publikováno v:
Journal of Neurochemistry. 101:263-273
Using mRNA differential display to identify cerebral ischemia-responsive mRNAs, we isolated and cloned a cDNA derived from a novel gene, that has been designated LCHN. Antisense mRNA in situ hybridization and immunoblotting confirmed LCHN expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7e4d8ba8053e3db5d2f8dfe1ce255eb
https://doi.org/10.1111/j.1471-4159.2006.04374.x
https://doi.org/10.1111/j.1471-4159.2006.04374.x
Publikováno v:
Experimental Cell Research. 312:2347-2357
Dysregulation of apoptosis is involved in a wide spectrum of disease ranging from proliferative to degenerative disorders. An emerging area of study in apoptosis is the critical contribution of the endoplasmic reticulum (ER) in both mitochondrial and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb984271c8eaf50f69a2b9e6b237218
https://doi.org/10.1016/j.yexcr.2006.03.027
https://doi.org/10.1016/j.yexcr.2006.03.027
Publikováno v:
Clinical Cancer Research. 12:3238-3242
X-linked inhibitor of apoptosis (XIAP), first identified in 1996 ([1][1]), is a member of the IAP family of endogenous caspase inhibitors that blocks the execution of apoptosis. The inhibitory function of XIAP can be reversed by its antagonists, wher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0b2ad511e69baa436a05d1e14797bf
https://doi.org/10.1158/1078-0432.ccr-06-0817
https://doi.org/10.1158/1078-0432.ccr-06-0817
Autor:
Jennifer A. Palarca, B. Glenn Stanley, Derek S. Welsbie, Arshad M. Khan, James W. Gurd, Elizabeth R. Gillard, Herman H. Cheung
Publikováno v:
The Journal of Neuroscience. 24:10603-10615
In rats, feeding can be triggered experimentally using many approaches. Included among these are (1) food deprivation and (2) acute microinjection of the neurotransmitterl-glutamate (Glu) or its receptor agonist NMDA into the lateral hypothalamic are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350ef2dc10581e7c24517d94d145b6b2
https://doi.org/10.1523/jneurosci.3390-04.2004
https://doi.org/10.1523/jneurosci.3390-04.2004