Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Herman, Wolosker"'
Autor:
Oluwarotimi O. Folorunso, Stephanie E. Brown, Jugajyoti Baruah, Theresa L. Harvey, Shekib A. Jami, Inna Radzishevsky, Herman Wolosker, James M. McNally, John A. Gray, Anju Vasudevan, Darrick T. Balu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The proper development and function of telencephalic GABAergic interneurons is critical for maintaining the excitation and inhibition (E/I) balance in cortical circuits. Glutamate contributes to cortical interneuron (CIN) development via N-m
Externí odkaz:
https://doaj.org/article/c1a3de421db14b62abea4c8f005bf011
Publikováno v:
Nat Rev Chem
The chirality of small metabolic molecules is important in controlling physiological processes and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules in biofluids and tissues occur in many diseases, including can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1f4c8af2b7f5d1c5e8c38c217f0c6b
https://europepmc.org/articles/PMC10175202/
https://europepmc.org/articles/PMC10175202/
Autor:
Stephen A. Tapanes, Dena Arizanovska, Madelen M. Díaz, Oluwarotimi O. Folorunso, Theresa Harvey, Stephanie E. Brown, Inna Radzishevsky, Liesl N. Close, Jonathan R. Jagid, Joacir Graciolli Cordeiro, Herman Wolosker, Darrick T. Balu, Daniel J. Liebl
Publikováno v:
Glia. 70:1133-1152
Synaptic damage is one of the most prevalent pathophysiological responses to traumatic CNS injury and underlies much of the associated cognitive dysfunction; however, it is poorly understood. The D-amino acid, D-serine, serves as the primary co-agoni
Autor:
Eva Ploux, Valentine Bouet, Inna Radzishevsky, Herman Wolosker, Thomas Freret, Jean-Marie Billard
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9447 (2020)
d-serine is the major co-agonist of N-methyl-D-aspartate receptors (NMDAR) at CA3/CA1 hippocampal synapses, the activation of which drives long-term potentiation (LTP). The use of mice with targeted deletion of the serine racemase (SR) enzyme has bee
Externí odkaz:
https://doaj.org/article/9f3e3b400fd7471d9e9cbecd25744db0
Publikováno v:
Neurochem Res
Shape-shifting, a phenomenon wide-spread in folklore, refers to the ability to physically change from one identity to another, typically from an innocuous entity to a destructive one. The amino acid D-serine over the last 25 years has "shape-shifted"
Autor:
Marialaura Marchetti, Hazem Safory, Shai Kellner, Simone Engelender, Shai Berlin, Inna Radzishevsky, Veronika N. Foltyn, Samah Neame, Francesco Marchesani, Ayelet Touitou, Jean-Marie Billard, Herman Wolosker
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (41), pp.20736-20742. ⟨10.1073/pnas.1909458116⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (41), pp.20736-20742. ⟨10.1073/pnas.1909458116⟩
Astrocytes express the 3-phosphoglycerate dehydrogenase (Phgdh) enzyme required for the synthesis of l-serine from glucose. Astrocytic l-serine was proposed to regulate NMDAR activity by shuttling to neurons to sustain d-serine production, but this h
Autor:
Inna Radzishevsky, Herman Wolosker
Publikováno v:
The Biochemical journal. 478(5)
Promiscuous catalysis is a common property of enzymes, particularly those using pyridoxal 5′-phosphate as a cofactor. In a recent issue of this journal, Katane et al. Biochem. J. 477, 4221–4241 demonstrate the synthesis and accumulation of d-glut
Autor:
Herman Wolosker, Darrick T. Balu
Publikováno v:
Translational Psychiatry
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Translational Psychiatry, Vol 10, Iss 1, Pp 1-10 (2020)
Fear, anxiety, and trauma-related disorders, including post-traumatic stress disorder (PTSD), are quite common and debilitating, with an estimated lifetime prevalence of ~28% in Western populations. They are associated with excessive fear reactions,
Autor:
Kevin Muszynski, Kerry J. Ressler, Joseph T. Coyle, Kendall Taylor Presti, Inna Radzishevsky, Darrick T. Balu, Cathy C.Y. Huang, Herman Wolosker, Guia Guffanti
Publikováno v:
Biological Psychiatry. 83:273-283
Background The amygdala is a central component of the neural circuitry that underlies fear learning. N-methyl-D-aspartate receptor–dependent plasticity in the amygdala is required for pavlovian fear conditioning and extinction. N-methyl-D-aspartate
Autor:
Ellie Shahbo, Darrick T. Balu, Jugajyoti Baruah, Anju Vasudevan, Ismail Ajjawi, Oluwarotimi Folorunso, Theresa L. Harvey, Herman Wolosker, Inna Radzishevsky
Publikováno v:
Biological Psychiatry. 89:S117