Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Herman, Meurs"'
Autor:
Hoeke A. Baarsma, Bing Han, Wilfred J. Poppinga, Saskia Driessen, Carolina R. S. Elzinga, Andrew J. Halayko, Herman Meurs, Harm Maarsingh, Martina Schmidt
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
With the ability to switch between proliferative and contractile phenotype, airway smooth muscle (ASM) cells can contribute to the progression of airway diseases such as asthma and chronic obstructive pulmonary disease (COPD), in which airway obstruc
Externí odkaz:
https://doaj.org/article/2689a820502b4991a3bb1673a2f9baab
Autor:
Harm Maarsingh, Anouk Oldenburger, Bing Han, Annet B. Zuidhof, Carolina R. S. Elzinga, Wim Timens, Herman Meurs, Ramadan B. Sopi, Martina Schmidt
Publikováno v:
Cells, Vol 10, Iss 5, p 1237 (2021)
Expression of bronchodilatory β2-adrenoceptors and bronchoconstrictive muscarinic M3-receptors alter with airway size. In COPD, (a combination of) β2-agonists and muscarinic M3-antagonists (anticholinergics) are used as bronchodilators. We studied
Externí odkaz:
https://doaj.org/article/5703f517814b4c94aeb70d034ab10194
Autor:
Inês Antunes, Reinoud Gosens, Nicole Willemsen-Seegers, Gonçalo S Clemente, Mariska P. M. van den Berg, Rogier C Buijsmam, Philip H. Elsinga, Herman Meurs, Aren van Waarde, Santosh Kurhade, Alexander Dömling, Jurgen W. A. Sijbesma
Publikováno v:
Journal of Nuclear Medicine, 62(8), 1163-1170. SOC NUCLEAR MEDICINE INC
Arginase hydrolyzes L-arginine and influences levels of polyamines and nitric oxide. Arginase overexpression is associated with inflammation and tumorigenesis. Thus, radiolabeled arginase inhibitors may be suitable PET tracers for staging arginase-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cadec3dc13f82a107c98fc4563af87f
https://research.rug.nl/en/publications/b60854b5-997c-48b6-93b9-edce5de84a96
https://research.rug.nl/en/publications/b60854b5-997c-48b6-93b9-edce5de84a96
Autor:
Alexander Dömling, Reinoud Gosens, Santosh Kurhade, I.R. Hulsbeek, Loes E. M. Kistemaker, Philip H. Elsinga, P.H. Boekema, Ido P. Kema, H. Maarsingh, M. van Faassen, Herman Meurs, M.P. van den Berg, S. Erceg
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics, 374(1), 62-73. WILLIAMS & WILKINS
Arginase is a potential target for asthma treatment. However, there are currently no arginase inhibitors available for clinical use. Here, a novel class of arginase inhibitors was synthesized, and their efficacy was pharmacologically evaluated. The r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1197320c0864c5069a404a6e418245a3
https://doi.org/10.1124/jpet.119.264341
https://doi.org/10.1124/jpet.119.264341
Autor:
Tonio Pera, Catrin Bitter, David Wright, Maarten van den Berge, Herman Meurs, Pavan Prabhala, Wim Timens, Bart G. J. Dekkers, Nick H. T. ten Hacken, P. Robbe
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology, 317(6), L768-L777. AMER PHYSIOLOGICAL SOC
Airway inflammation and remodeling are characteristic features of asthma, with both contributing to airway hyperresponsiveness (AHR) and lung function limitation. Airway smooth muscle (ASM) accumulation and extracellular matrix deposition are charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6829d65f1c9f9d18bfeb48a2e6637a04
https://doi.org/10.1152/ajplung.00222.2019
https://doi.org/10.1152/ajplung.00222.2019
Autor:
Reinoud Gosens, Martina Schmidt, Herman Meurs, Loes E. M. Kistemaker, Daniel Seeliger, Michael P. Pieper, Suraya Alikhil, Carolina R.S. Elzinga, Christofer S. Tautermann
Publikováno v:
British Journal of Pharmacology, 176(16), 2864-2876. Wiley-Blackwell
Background and Purpose The bronchodilator tiotropium binds not only to its main binding site on the M-3 muscarinic receptor but also to an allosteric site. Here, we have investigated the functional relevance of this allosteric binding and the potenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbfc34dfe97f8c21425ed76d4c7d79f
https://doi.org/10.1111/bph.14707
https://doi.org/10.1111/bph.14707
Autor:
Fiona Westerhof, Wim Timens, Annemiek van Oosten, Annet B. Zuidhof, Nathalie Nauta, Martin Schuiling, Johannes T. W. M. Vos, Johan Zaagsma, Herman Meurs, Wilko Coers
Publikováno v:
Mediators of Inflammation, Vol 10, Iss 3, Pp 143-154 (2001)
Although airway inflammation and airway hyperreactivity are observed after allergen inhalation both in allergic humans and animals, little is known about the mechanisms by which inflammatory cells can contribute to allergen-induced airway hyperreacti
Externí odkaz:
https://doaj.org/article/7eab2f7eb46441e184d01a5324d91b64
Autor:
Annet B. Zuidhof, Anouk Oldenburger, Carolina R.S. Elzinga, Ramadan B Sopi, Herman Meurs, Bing Han, Wim Timens, Martina Schmidt, H. Maarsingh
Publikováno v:
Cells, Vol 10, Iss 1237, p 1237 (2021)
Cells, 10(5):1237. MDPI AG
Cells
Volume 10
Issue 5
Cells, 10(5):1237. MDPI AG
Cells
Volume 10
Issue 5
Expression of bronchodilatory β2-adrenoceptors and bronchoconstrictive muscarinic M3-receptors alter with airway size. In COPD, (a combination of) β2-agonists and muscarinic M3-antagonists (anticholinergics) are used as bronchodilators. We studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829fb69197e3336c57a49017222fc58c
https://www.mdpi.com/2073-4409/10/5/1237
https://www.mdpi.com/2073-4409/10/5/1237
Autor:
Herman Meurs, Dyon A. L. J. Mertens, Reinoud Gosens, Stephen Evans, Mariska P. M. van den Berg, Kai Gao, Zayana M Al-Dahmani, Matthew Groves, Sergey Lunev
Publikováno v:
Molecular Biology Reports
Molecular Biology Reports, 48(2). SPRINGER
Molecular Biology Reports, 48(2). SPRINGER
Arginine metabolism mediated by arginases plays a critical role in cell and tissue function. The arginine hydrolysis is deeply involved in the urea cycle, which helps the kidney excrete ammonia from blood. Upregulation of arginases affects microenvir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c829b0057deec5e59fb53da8b5000e81
https://hdl.handle.net/11370/4735461b-fad9-4bc5-a6bf-d6a677154758
https://hdl.handle.net/11370/4735461b-fad9-4bc5-a6bf-d6a677154758
Autor:
Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65580 (2013)
Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood. A possible player i
Externí odkaz:
https://doaj.org/article/054f34fd3c7a4061b407e60f6dc9d9a1