Thrombin generation, bleeding and hemostasis in humans: Protocol for a scoping review of the literature.

Autor: Joseph R Shaw, Tyler James, Jonathan Douxfils, Yesim Dargaud, Jerrold H Levy, Herm Jan M Brinkman, Risa Shorr, Deborah Siegal, Lana A Castellucci, Peter Gross, Roy Khalife, Christine Sperling, David Page, Dean Fergusson, Marc Carrier

Publikováno v: PLoS ONE, Vol 18, Iss 11, p e0293632 (2023)

IntroductionHemostasis and bleeding are difficult to measure. Thrombin generation assays (TGAs) can measure both procoagulant and anticoagulant contributions to coagulation. TGAs might prove useful for the study of bleeding disorders. There has been

Externí odkaz: https://doaj.org/article/2d470222b64f48ac860bd595f5bbe481

Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro

Autor: Herm Jan M. Brinkman, Frauke Swieringa, Marleen Zuurveld, Alicia Veninga, Sanne L. N. Brouns, Johan W. M. Heemskerk, Joost C. M. Meijers

Publikováno v: Research and Practice in Thrombosis and Haemostasis, Vol 6, Iss 3, Pp n/a-n/a (2022)

Abstract Background Prothrombin complex concentrate (PCC) is a human plasma‐derived mixture of partially purified vitamin K‐dependent coagulation factors (VKCF). Current therapeutic indication is treatment and perioperative prophylaxis of bleedin

Externí odkaz: https://doaj.org/article/686b1ea5e4d14d848f33507bf2dc4b31

Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH

Autor: Josefin Ahnström, Björn Dahlbäck, Elisabetta Castoldi, Richard A. Marlar, Herm Jan M. Brinkman

Publikováno v: Journal of Thrombosis and Haemostasis, 19(1), 281-286. Wiley

Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter-individual variability makes it problematic to esta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a58f7138caebadcdce1cb9a14c891d
https://cris.maastrichtuniversity.nl/en/publications/f98462cc-f8c7-471f-b05d-381205764026

Emergencies on direct oral anticoagulants

Autor: Herm Jan M. Brinkman, Saskia Middeldorp, Barbara A. Hutten, Marjolein P. A. Brekelmans, Michiel Coppens, Marieke J. H. A. Kruip, Eva N. Hamulyák, Rahat A. Abdoellakhan, Karina Meijer, Peter E. Westerweel, Hugo ten Cate, Renske H. Olie, Marleen Zuurveld, Roisin Bavalia

Publikováno v: Research and practice in thrombosis and haemostasis, 4(4), 569-581. Wiley
Research and Practice in Thrombosis and Haemostasis, 4(4), 569-581. Wiley-Blackwell Publishing Ltd
Research and Practice in Thrombosis and Haemostasis
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 4, Pp 569-581 (2020)
Research and practice in thrombosis and haemostasis, 4(4), 569-581. Wiley-Blackwell Publishing Ltd

Background In the initial absence of specific reversal agents for factor Xa inhibitors (FXa-Is), prothrombin complex concentrate (PCC) as a hemostatic agent has been recommended by guidelines. Since 2017, idarucizumab has been registered for dabigatr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f0368b4df92c7256a467c04bad2999
https://hdl.handle.net/11370/90876bf2-f7b8-4774-a8b9-77266e16545a

Use of DOAC Stop for elimination of anticoagulants in the thrombin generation assay

Autor: Joost C. M. Meijers, Wil F. Kopatz, Herm Jan M. Brinkman

Publikováno v: Thrombosis research, 170, 97-101. Elsevier Limited

Calibrated automated thrombography (CAT) is useful in monitoring the anticoagulant status of patients treated with direct oral anticoagulants (DOACs). This as well as other applications of the CAT are hampered by the wide inter-individual variation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c8ecab29e7e9f991a64381208b74d9
https://doi.org/10.1016/j.thromres.2018.08.014