Clinical Trial Registration Patterns and Changes in Primary Outcomes of Randomized Clinical Trials from 2002 to 2017

Autor: Herm J. Lamberink, Christiaan H. Vinkers, Michelle Lancee, Johanna A. A. Damen, Lex M. Bouter, Willem M. Otte, Joeri K. Tijdink

Publikováno v: Lamberink, H J, Vinkers, C H, Lancee, M, Damen, J A A, Bouter, L M, Otte, W M & Tijdink, J K 2022, ' Clinical Trial Registration Patterns and Changes in Primary Outcomes of Randomized Clinical Trials from 2002 to 2017 ', Jama internal medicine, vol. 182, no. 7, pp. 779-782 . https://doi.org/10.1001/jamainternmed.2022.1551
Jama internal medicine, 182(7), 779-782. American Medical Association
JAMA Internal Medicine, 182(7), 779-782. American Medical Association
Lamberink, H J, Vinkers, C H, Lancee, M, Damen, J A A, Bouter, L M, Otte, W M & Tijdink, J K 2022, ' Clinical Trial Registration Patterns and Changes in Primary Outcomes of Randomized Clinical Trials from 2002 to 2017 ', JAMA Internal Medicine, vol. 182, no. 7, pp. 779-782 . https://doi.org/10.1001/jamainternmed.2022.1551
JAMA Intern Med

This cross-sectional study evaluates the existence and timing of trial registration for randomized clinical trials (RCTs) published from 2002 to 2017 as well as substantive changes to the primary outcomes entered into registry information after those

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0ce3fd62e8f6d80588fea4435546fb
https://doi.org/10.1001/jamainternmed.2022.1551

Cumulative effects of antiseizure medication on intelligence in children with focal epilepsy

Autor: Carmen H, Stevering, Herm J, Lamberink, Julie, Woodfield, Monique, van Schooneveld, Willem M, Otte, Richard F M, Chin, Mark E, Bastin, Karin, Geleijns, Kees P J, Braun

Publikováno v: Epileptic disorders : international epilepsy journal with videotape. 24(5)

Antiseizure medication may have long-term effects on the neurodevelopment of children. We aimed to investigate the association between cumulative antiseizure medication load and intelligence quotient (IQ) in relation to brain volume and cortical thic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4425b572bcc7037280b47886dd57a639
https://pubmed.ncbi.nlm.nih.gov/35904036

Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: A systematic review and individual participant data meta-analysis

Autor: Remi Stevelink, Dania Al-Toma, Floor E. Jansen, Herm J. Lamberink, Ali A. Asadi-Pooya, Mohsen Farazdaghi, Gonçalo Cação, Sita Jayalakshmi, Anuja Patil, Çiğdem Özkara, Şenay Aydın, Joanna Gesche, Christoph P. Beier, Linda J. Stephen, Martin J. Brodie, Gopeekrishnan Unnithan, Ashalatha Radhakrishnan, Julia Höfler, Eugen Trinka, Roland Krause, Emanuele Cerulli Irelli, Carlo Di Bonaventura, Jerzy P. Szaflarski, Laura E. Hernández-Vanegas, Monica L. Moya-Alfaro, Yingying Zhang, Dong Zhou, Nicola Pietrafusa, Nicola Specchio, Giorgi Japaridze, Sándor Beniczky, Mubeen Janmohamed, Patrick Kwan, Marte Syvertsen, Kaja K. Selmer, Bernd J. Vorderwülbecke, Martin Holtkamp, Lakshminarayanapuram G. Viswanathan, Sanjib Sinha, Betül Baykan, Ebru Altindag, Felix von Podewils, Juliane Schulz, Udaya Seneviratne, Alejandro Viloria-Alebesque, Ioannis Karakis, Wendyl J. D'Souza, Josemir W. Sander, Bobby P.C. Koeleman, Willem M. Otte, Kees P.J. Braun

Publikováno v: info:eu-repo/grantAgreement/EC/FP7/279062
Stevelink, R, Al-Toma, D, Jansen, F E, Lamberink, H J, Asadi-Pooya, A A, Farazdaghi, M, Cação, G, Jayalakshmi, S, Patil, A, Özkara, Ç, Aydın, Ş, Gesche, J, Beier, C P, Stephen, L J, Brodie, M J, Unnithan, G, Radhakrishnan, A, Höfler, J, Trinka, E, Krause, R, Irelli, E C, Di Bonaventura, C, Szaflarski, J P, Hernández-Vanegas, L E, Moya-Alfaro, M L, Zhang, Y, Zhou, D, Pietrafusa, N, Specchio, N, Japaridze, G, Beniczky, S, Janmohamed, M, Kwan, P, Syvertsen, M, Selmer, K K, Vorderwülbecke, B J, Holtkamp, M, Viswanathan, L G, Sinha, S, Baykan, B, Altindag, E, von Podewils, F, Schulz, J, Seneviratne, U, Viloria-Alebesque, A, Karakis, I, D'Souza, W J, Sander, J W, Koeleman, B P C, Otte, W M & EpiPGX Consortium 2022, ' Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy : A systematic review and individual participant data meta-analysis ', EClinicalMedicine, vol. 53, 101732 . https://doi.org/10.1016/j.eclinm.2022.101732

Background: A third of people with juvenile myoclonic epilepsy (JME) are drug-resistant. Three-quarters have a seizure relapse when attempting to withdraw anti-seizure medication (ASM) after achieving seizure-freedom. It is currently impossible to pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df10b97efe0fd76c0693a542cc69a6e9
https://hdl.handle.net/11573/1659040

The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement

Autor: Herm J. Lamberink, Christiaan H. Vinkers, Pauline Heus, Willem M. Otte, David Moher, Lex M. Bouter, Johanna A A G Damen, Lotty Hooft, Paul Glasziou, Joeri K. Tijdink

Publikováno v: Vinkers, C H, Lamberink, H J, Tijdink, J K, Heus, P, Bouter, L, Glasziou, P, Moher, D, Damen, J A, Hooft, L & Otte, W M 2021, ' The methodological quality of 176,620 randomized controlled trials published between 1966 and 2018 reveals a positive trend but also an urgent need for improvement ', PloS Biology, vol. 19, no. 4, e3001162, pp. e3001162 . https://doi.org/10.1371/journal.pbio.3001162
PLoS Biology, Vol 19, Iss 4, p e3001162 (2021)
PloS Biology, 19(4):e3001162. Public Library of Science
PLoS Biology

Many randomized controlled trials (RCTs) are biased and difficult to reproduce due to methodological flaws and poor reporting. There is increasing attention for responsible research practices and implementation of reporting guidelines, but whether th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8864190908b6cfd89372ab7feb553554
https://research.vumc.nl/en/publications/032b34d4-35be-4f47-8708-b685f1948838

Randomized clinical trial quality has improved over time but is still not good enough: an analysis of 176,620 randomized controlled trials published between 1966 and 2018

Autor: Christiaan H. Vinkers, Lex M. Bouter, Pauline Heus, David Moher, Johanna A A G Damen, Willem M. Otte, Herm J. Lamberink, Paul Glasziou, Joeri K. Tijdink, Lotty Hooft

BackgroundMany randomized controlled trials (RCTs) are biased and difficult to reproduce due to methodological flaws and poor reporting. There is increasing attention for responsible research practices including reporting guidelines, but it is unknow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fe877358d8c5fcd2e1f74d2cbd9fa3a