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of 598
pro vyhledávání: '"Herling, Marco"'
T-cell prolymphocytic leukemia (T-PLL) is a rare blood cancer with poor prognosis. Overexpression of the proto-oncogene TCL1A and missense mutations of the tumor suppressor ATM are putative main drivers of T-PLL development, but so far only little is
Externí odkaz:
https://tud.qucosa.de/id/qucosa%3A89823
https://tud.qucosa.de/api/qucosa%3A89823/attachment/ATT-0/
https://tud.qucosa.de/api/qucosa%3A89823/attachment/ATT-0/
Mature T-cell leukemias represent rare, but increasingly recognized diseases of which, compared to their B-cell counterparts, comparatively little is established on their pathogenesis, diagnosis, and treatment. These leukemic post-thymic T-cell neopl
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A88999
https://ul.qucosa.de/api/qucosa%3A88999/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A88999/attachment/ATT-0/
Autor:
Goehringer, Nils, Biersack, Bernhard, Peng, Yayi, Schobert, Rainer, Herling, Marco, Ma, Andi, Nitzsche, Bianca, Höpfner, Michael
New chimeric inhibitors targeting the epidermal growth factor (EGFR) and histone deacetylases (HDACs) were synthesized and tested for antineoplastic efficiency in solid cancer (prostate and hepatocellular carcinoma) and leukemia/lymphoma cell models.
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A89221
https://ul.qucosa.de/api/qucosa%3A89221/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A89221/attachment/ATT-0/
Autor:
Goehringer, Nils, Peng, Yayi, Nitzsche, Bianca, Biermann, Hannah, Pradhan, Rohan, Schobert, Rainer, Herling, Marco, Höpfner, Michael, Biersack, Bernhard
The development of new anticancer drugs is necessary in order deal with the disease and with the drawbacks of currently applied drugs. Epigenetic dysregulations are a central hallmark of cancerogenesis and histone deacetylases (HDACs) emerged as prom
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A85358
https://ul.qucosa.de/api/qucosa%3A85358/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A85358/attachment/ATT-0/
Autor:
Schönefeldt, Susann, Wais, Tamara, Herling, Marco, Mustjoki, Satu, Bekiaris, Vasileios, Moriggl, Richard, Neubauer, Heidi A.
γδ T cells are unique players in shaping immune responses, lying at the intersection between innate and adaptive immunity. Unlike conventional αβ T cells, γδ T cells largely populate non-lymphoid peripheral tissues, demonstrating tissue specifi
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A85091
https://ul.qucosa.de/api/qucosa%3A85091/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A85091/attachment/ATT-0/
Incomplete biological concepts in lymphoid neoplasms still dictate to a large extent the limited availability of efficient targeted treatments, which entertains the mostly unsatisfactory clinical outcomes. Aberrant expression of the embryonal and lym
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84987
https://ul.qucosa.de/api/qucosa%3A84987/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84987/attachment/ATT-0/
Autor:
Wenzel, Freya, Pralong, Anne, Holtick, Udo, Scheid, Christoph, Herling, Marco, Simon, Steffen T.
Graft-versus-host disease (GvHD) is a frequent, and often life-threatening, complication after an allogeneic, hematopoietic stem cell transplantation (allo-SCT). It can appear in an acute or a chronic form and presents different grades of severity. P
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84976
https://ul.qucosa.de/api/qucosa%3A84976/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84976/attachment/ATT-0/
Autor:
Pflug, Natali, Littauer, Annika, Beverungen, David, Sretenovic, Aleksandra, Wahnschaffe, Linus, Braun, Till, Dechow, Annika, Jungherz, Dennis, Otte, Moritz, Monecke, Astrid, Bach, Enrica, Franke, Georg-Nikolaus, Schwind, Sebastian, Jentzsch, Madlen, Platzbecker, Uwe, Herling, Marco, Vucinic, Vladan
Large granular lymphocyte leukemia (LGLL) represents a rare group of diseases with considerable difficulties in their correct diagnostic workup and therapy. The major challenges lie in their distinction from reactive (including autoimmune) lymphoprol
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84566
https://ul.qucosa.de/api/qucosa%3A84566/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84566/attachment/ATT-0/
According to the classical paradigm, CCR7 is a homing chemokine receptor that grants normal lymphocytes access to secondary lymphoid tissues such as lymph nodes or spleen. As such, in most lymphoproliferative disorders, CCR7 expression correlates wit
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84397
https://ul.qucosa.de/api/qucosa%3A84397/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84397/attachment/ATT-0/
Autor:
Braun, Till, Dechow, Annika, Friedrich, Gregor, Seifert, Michael, Stachelscheid, Johanna, Herling, Marco
T-cell prolymphocytic leukemia (T-PLL) is the most common mature T-cell leukemia. It is a typically aggressively growing and chemotherapy-resistant malignancy with a poor prognosis. T-PLL cells resemble activated, post-thymic T-lymphocytes with memor
Externí odkaz:
https://ul.qucosa.de/id/qucosa%3A84401
https://ul.qucosa.de/api/qucosa%3A84401/attachment/ATT-0/
https://ul.qucosa.de/api/qucosa%3A84401/attachment/ATT-0/