Zobrazeno 1 - 10 of 83 pro vyhledávání: '"Heribert Bohlen"'
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Akademický článek
Differentiation and selection of hepatocyte precursors in suspension spheroid culture of transgenic murine embryonic stem cells.
Autor: Elke Gabriel, Stephanie Schievenbusch, Eugen Kolossov, Jan G Hengstler, Tamara Rotshteyn, Heribert Bohlen, Dirk Nierhoff, Jürgen Hescheler, Irina Drobinskaya
Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44912 (2012)
Embryonic stem cell-derived hepatocyte precursor cells represent a promising model for clinical transplantations to diseased livers, as well as for establishment of in vitro systems for drug metabolism and toxicology investigations. This study aimed
Externí odkaz: https://doaj.org/article/955c0b2c2cd349a79bc40d242d6cdad9
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2
Selectively expressed RNA molecules: a new dimension in functionalized cell targeting
Autor: Marco Hoffmann, Sylvie Schüle, Christina Hoffmann, Frederik Rastfeld, Sven Gerlach, N. Hersch, Helene L. Walter, Dirk Wiedermann, Gereon R. Fink, Rudolf Merkel, Heribert Bohlen, Maria A. Rueger, Bernd Hoffmann
Exact targeting of specific mammalian cell types or diseased cells is one of the most urgently needed prerequisites for a new generation of potent pharmaceuticals. Different approaches have been pursued, failing mainly due to a lack of specific surfa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::81f4d0a2f33752276edd2d4f417eb766
https://doi.org/10.1101/2022.05.10.491309
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4
An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities
Autor: Joseph R. Woska, Heribert Bohlen, Greg Luerman, Walter Volberg, Luke Coyle, Ralf Kettenhofen, Brian Knight, Bryan J. Koci, Martha Priscilla Brown, Anika Duenbostell, Warren W. Ku
Publikováno v: Toxicology and Applied Pharmacology. 329:121-127
Current in vitro approaches to cardiac safety testing typically focus on mechanistic ion channel testing to predict in vivo proarrhythmic potential. Outside of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, structural and functiona
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b3d99cbb2a2c89e49eac29a4f4ef91
https://doi.org/10.1016/j.taap.2017.05.023
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5
Synchronized electromechanical integration recording of cardiomyocytes
Autor: Heribert Bohlen, Yu Shrike Zhang, Xiaoyu Zhang, Hao Wan, Xu Hou, Wanhong Xu, Matthias Gossmann, Ralf Kettenhofen, Liujing Zhuang, Ning Hu, Tianxing Wang, Ping Wang
Publikováno v: Biosensorsbioelectronics. 117
Cardiac issues are always one of major health problems that attract wide attention by the public. It is urgent to explore a preclinical strategy to efficiently prevent the life-threatening arrhythmias by precisely assessing the cardiac excitation-con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d314eac1f87e64b7fd42ec493b768e
https://pubmed.ncbi.nlm.nih.gov/29940523
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6
Frequency-Dependent Multi-Well Cardiotoxicity Screening Enabled by Optogenetic Stimulation
Autor: Daniela Malan, Heribert Bohlen, Leo Doerr, Benjamin Wolters, Susanne Rehnelt, Matthias Beckler, Philipp Sasse, Ralf Kettenhofen, Tobias Bruegmann, Krisztina Juhasz
Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 12; Pages: 2634
International Journal of Molecular Sciences, Vol 18, Iss 12, p 2634 (2017)
Side effects on cardiac ion channels causing lethal arrhythmias are one major reason for drug withdrawals from the market. Field potential (FP) recording from cardiomyocytes, is a well-suited tool to assess such cardiotoxic effects of drug candidates
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01dc57be04d2f63e73a916951652dd6
https://pubmed.ncbi.nlm.nih.gov/34070702
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8
Progressive multifokale Leukenzephalopathie
Autor: Bastian Malzkorn, Christian Mathys, Heribert Bohlen, Rüdiger J. Seitz, Damian Franzen, Jan Vesper
Publikováno v: DMW - Deutsche Medizinische Wochenschrift. 140:1291-1293
Die progressive multifokale Leukenzepalopathie (PML) ist eine seltene demyeliniserende Erkrankung des Zentralnervensystems, die durch eine Reaktivierung des John-Cunningham-Virus (JCV) unter zellularer Immunsuppression auftreten kann. Charakterisiert
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::092ff6fc4d958b42cec85bd91b2eb8a9
https://doi.org/10.1055/s-0041-103278
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9
Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction
Autor: Niels Fertig, Eugen Kolossov, Sonja Stoelzle, Alison Haythornthwaite, Heribert Bohlen, Andrea Brüggemann, Michael George, Ralf Kettenhofen
Publikováno v: SLAS Discovery. 16:910-916
Cardiovascular side effects are critical in drug development and have frequently led to late-stage project terminations or even drug withdrawal from the market. Physiologically relevant and predictive assays for cardiotoxicity are hence strongly dema
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4942aed9de4d75b5b0ed3e2b0680943a
https://doi.org/10.1177/1087057111413924
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