Zobrazeno 1 - 10
of 226
pro vyhledávání: '"Herfried Griengl"'
Autor:
Herfried Griengl, Martin H. Fechter
Publikováno v:
Food Technology and Biotechnology, Vol 42, Iss 4, Pp 287-294 (2004)
We review the state of the art regarding the application of hydroxynitrile lyases to obtain, enantioselectively, (R)- and (S)-cyanohydrins of aldehydes and ketones. Special emphasis is given to recent preparative applications and to research for exte
Externí odkaz:
https://doaj.org/article/2eed607f93df4167b769308c15447abc
Publikováno v:
Food Technology and Biotechnology, Vol 40, Iss 1, Pp 9-19 (2002)
(S)-Hydroxynitrile lyase from Hevea brasiliensis (HbHnl) (EC 4.1.2.39) catalyzes the reversible synthesis of chiral cyanohydrins from aldehydes or ketones and HCN. The enzymatic formation of (S)-mandelonitrile (MN) from benzaldehyde (BA) and HCN was
Externí odkaz:
https://doaj.org/article/d147a04b762f4e70b58af69e0043fa60
Publikováno v:
Biocatalysis and Biotransformation. 28:348-356
The asymmetric Henry reaction catalyzed by hydroxynitrile lyase from Hevea brasiliensis is an example of enzymatic catalytic promiscuity. It could be an attractive method to produce optically active β-nitroalcohols, but unfortunately the enzyme has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::640739704ec4bd661fee32f3cb3c7063
https://doi.org/10.3109/10242422.2010.530661
https://doi.org/10.3109/10242422.2010.530661
Publikováno v:
ChemCatChem. 2:981-986
Hydroxynitrile lyase from Hevea brasiliensis (HbHNL) is a promiscuous biocatalyst that, besides the native cyanohydrin reaction, also catalyzes the asymmetric Henry reaction yielding (5)-β-nitroalcohols with high enantiomeric excess. Since the Henry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc3828e39f011024f30d28ee3f1b46bd
https://doi.org/10.1002/cctc.201000147
https://doi.org/10.1002/cctc.201000147
Autor:
Karl Gruber, Manuela Avi, Juliane Keilitz, Herfried Griengl, Georg Steinkellner, Rainer Haag, Chakib Hajji
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 61:268-273
3,4-Dihydro-2H-pyran-2-carbaldehyde (1) and 2-methoxycyclohex-3-encarbaldehyde (2) obtained by thermal or chemocatalytic Diels–Alder reactions were converted into the corresponding cyanohydrins by hydroxynitrile lyase catalysis. Modelling investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d26370ab9accb37122e8873cf771a1f9
https://doi.org/10.1016/j.molcatb.2009.08.005
https://doi.org/10.1016/j.molcatb.2009.08.005
Publikováno v:
Angewandte Chemie International Edition. 49:121-124
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8317b0ffd7174ae521d59a01d40a98a7
https://doi.org/10.1002/anie.200904395
https://doi.org/10.1002/anie.200904395
Autor:
Franz Stefan Hartner, Tanja Sović, Herfried Griengl, Aleksandra Andryushkova, Georg Steinkellner, Thomas Purkarthofer, Gernot Strohmeier, Anton Glieder, Karl Gruber
Publikováno v:
Tetrahedron. 65:5663-5668
Conjugate additions of carbon nucleophiles to appropriate acceptor molecules were investigated with respect to the synthetic potential and stereochemistry of the products. Reactions of short-chain α,β-unsaturated ketones and mono-substituted nitroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d966d350925c8952051ca7d8bc6beaa2
https://doi.org/10.1016/j.tet.2009.05.042
https://doi.org/10.1016/j.tet.2009.05.042
Publikováno v:
Tetrahedron. 65:5418-5426
A de novo synthesis of pentoses is described starting from (Z)-2-buten-1,4-diol (1). The key step is the enzyme catalysed enantioselective HCN-addition to O-protected 4-hydroxybut-2-enal using the hydroxynitrile lyase from Hevea brasiliensis, followe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc5f62b33328e48ffe10800ea72e27df
https://doi.org/10.1016/j.tet.2009.04.048
https://doi.org/10.1016/j.tet.2009.04.048
Publikováno v:
Chemistry - A European Journal. 14:11415-11422
Even if biocatalysis is finding increasing application, it still has to gain widespread use in synthetic chemistry. Reasons for this are limitations that enzymes have with regard to substrate range, reaction scope, and insufficient selectivity with u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de939e3dcdc850f4223c0cba2f1a557e
https://doi.org/10.1002/chem.200800609
https://doi.org/10.1002/chem.200800609
Autor:
Zhibin Liu, Manuela Avi, Richard Gaisberger, Anton Glieder, Karl Gruber, Wolfgang Skranc, Beate Pscheidt, Herfried Griengl
Publikováno v:
Advanced Synthesis & Catalysis. 350:1943-1948
Screening for stereoselective cyanohydrin synthesis in 96-well plates was employed in the development of an efficient, pH-stable hydroxynitrile lyase for the conversion of sterically hindered aliphatic aldehydes. Site-saturation mutagenesis (SSM) res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728ffeb28f91ea41641c308206117438
https://doi.org/10.1002/adsc.200800354
https://doi.org/10.1002/adsc.200800354