Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hereditary diffuse gastric cancer (HDGC)"'
Publikováno v:
Сибирский онкологический журнал, Vol 17, Iss 4, Pp 48-52 (2018)
For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. The case report describes a rare case of hereditary diffuse ga
Externí odkaz:
https://doaj.org/article/f70d94e4a0c54e638b085d8c70b36a03
Autor:
Olsi Gjyshi, Pankaj Vashi, Laura Seewald, Mitra Kohan, Elham Abboud, Eric Fowler, Revathi Suppiah, Hatem Halabi
Publikováno v:
World Journal of Surgical Oncology, Vol 16, Iss 1, Pp 1-8 (2018)
Abstract Background Gastric cancer is the fifth most prevalent and the third most lethal cancer worldwide, causing approximately 720,000 deaths annually. Although most cases of gastric cancers are sporadic, one of its inherited forms, hereditary diff
Externí odkaz:
https://doaj.org/article/a5cbd15b9184465a93819bd073a5f8f3
Autor:
Ina Chen, Lesley Mathews-Greiner, Dandan Li, Abisola Abisoye-Ogunniyan, Satyajit Ray, Yansong Bian, Vivek Shukla, Xiaohu Zhang, Raj Guha, Craig Thomas, Berkley Gryder, Athina Zacharia, Joal D. Beane, Sarangan Ravichandran, Marc Ferrer, Udo Rudloff
Publikováno v:
Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-16 (2017)
Abstract Background Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked differences in natural
Externí odkaz:
https://doaj.org/article/d6dcaf17bdb84036b90130567203e47c
Akademický článek
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Hereditary diffuse gastric cancer is an autosomal dominant syndrome characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is caused by inactivating mutations in the tumor suppressor gene CDH1. Genetic testing tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e290626a1f8b978f831748b6f0158c84
https://epub.uni-regensburg.de/52752/
https://epub.uni-regensburg.de/52752/
Autor:
Joseph D. Forrester, Deshka Foster, James M. Ford, Teri A. Longacre, Uri Ladabaum, Sara Fry, Jeffrey A. Norton
Publikováno v:
Cancers, Vol 14, Iss 728, p 728 (2022)
Introduction: Gastric cancer is inherited as an autosomal dominant condition in hereditary diffuse gastric cancer (HDGC). The gene associated with HDGC is an E-cadherin gene CDH1. At the time of initiation of this study, it was estimated that 70% of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c653ff2fd6ba6180a8ef29f120a032f7
https://pubmed.ncbi.nlm.nih.gov/35158993
https://pubmed.ncbi.nlm.nih.gov/35158993
Akademický článek
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Autor:
Fátima Carneiro, Francesco Limarzi, Irene Gullo, Alessandro Vanoli, Luca Mastracci, Matteo Fassan, Luca Saragoni, Federica Grillo, Jacopo Ferro, Paola Parente
Publikováno v:
Pathologica
Summary Gastric cancer accounts for about 6% of cancers worldwide, being the fifth most frequently diagnosed malignancy and the third leading cause of cancer related death. Gastric carcinogenesis is a multistep and multifactorial process and is the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcc1a544474a402b14b576c33479024
https://hdl.handle.net/10216/145232
https://hdl.handle.net/10216/145232
Autor:
Maria Sofia Fernandes, Parry Guilford, Ana Sofia Ribeiro, Patrícia Carneiro, Raquel Seruca, Soraia Melo, Joana Figueiredo, Ana Margarida Moreira, Joana Paredes
Publikováno v:
Journal of Medical Genetics
CDH1encodes E-cadherin, a key protein in adherens junctions. Given that E-cadherin is involved in major cellular processes such as embryogenesis and maintenance of tissue architecture, it is no surprise that deleterious effects arise from its loss of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facd22d32726b10e1d2b906f0d3d5568
http://europepmc.org/articles/PMC6581119
http://europepmc.org/articles/PMC6581119
Akademický článek
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