Zobrazeno 1 - 10 of 142 pro vyhledávání: '"Herdeis L"'
1
Akademický článek
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth.
Autor: Kim D; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Herdeis L; Boehringer Ingelheim, Vienna, Austria., Rudolph D; Boehringer Ingelheim, Vienna, Austria., Zhao Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Böttcher J; Boehringer Ingelheim, Vienna, Austria., Vides A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Ayala-Santos CI; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pourfarjam Y; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Cuevas-Navarro A; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Xue JY; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Mantoulidis A; Boehringer Ingelheim, Vienna, Austria., Bröker J; Boehringer Ingelheim, Vienna, Austria., Wunberg T; Boehringer Ingelheim, Vienna, Austria., Schaaf O; Boehringer Ingelheim, Vienna, Austria., Popow J; Boehringer Ingelheim, Vienna, Austria., Wolkerstorfer B; Boehringer Ingelheim, Vienna, Austria., Kropatsch KG; Boehringer Ingelheim, Vienna, Austria., Qu R; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sang B; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Li C; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., McConnell DB; Boehringer Ingelheim, Vienna, Austria., Kraut N; Boehringer Ingelheim, Vienna, Austria., Lito P; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. litop@mskcc.org.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. litop@mskcc.org.
Publikováno v: Nature [Nature] 2023 Jul; Vol. 619 (7968), pp. 160-166. Date of Electronic Publication: 2023 May 31.
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2
Akademický článek
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
Autor: Bröker J; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Waterson AG; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Smethurst C; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Kessler D; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Böttcher J; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Mayer M; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Gmaschitz G; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Phan J; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Little A; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Abbott JR; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Sun Q; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States., Gmachl M; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Rudolph D; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Arnhof H; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Rumpel K; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Savarese F; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Gerstberger T; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Mischerikow N; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Treu M; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Herdeis L; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Wunberg T; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Gollner A; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Weinstabl H; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Mantoulidis A; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., Krämer O; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., McConnell DB; Boehringer Ingelheim RCV GmbH & Co. KG, Dr. Boehringer Gasse 5-11, A-1121 Vienna, Austria., W Fesik S; Department of Biochemistry, Vanderbilt University School of Medicine, 2215 Garland Avenue, 607 Light Hall, Nashville, Tennessee 37232-0146, United States.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Nov 10; Vol. 65 (21), pp. 14614-14629. Date of Electronic Publication: 2022 Oct 27.
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3
Akademický článek
Stopping the beating heart of cancer: KRAS reviewed.
Autor: Herdeis L; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120, Vienna, Austria., Gerlach D; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120, Vienna, Austria., McConnell DB; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120, Vienna, Austria., Kessler D; Discovery Research, Boehringer Ingelheim Regional Center Vienna GmbH & Co KG, 1120, Vienna, Austria. Electronic address: dirk.kessler@boehringer-ingelheim.com.
Publikováno v: Current opinion in structural biology [Curr Opin Struct Biol] 2021 Dec; Vol. 71, pp. 136-147. Date of Electronic Publication: 2021 Jul 22.
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4
Akademický článek
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5
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
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6
Akademický článek
Dual inhibition of HERs and PD-1 counteract resistance in KRASG12C-mutant head and neck cancer.
Autor: Novoplansky, Ofra1,2 (AUTHOR), Jagadeeshan, Sankar1,2 (AUTHOR), Prasad, Manu1,2 (AUTHOR), Yegodayev, Ksenia M.1,2 (AUTHOR), Marripati, Divyasree1,2 (AUTHOR), Shareb, Raghda Abu1,2 (AUTHOR), Greenshpan, Yariv1,2 (AUTHOR), Mathukkada, Sooraj1,2 (AUTHOR), Ben-Lulu, Talal1,2 (AUTHOR), Bhattacharya, Baisali1,2 (AUTHOR), Porgador, Angel1,2 (AUTHOR), Kong, Dexin3 (AUTHOR), Brägelmann, Johannes4,5,6 (AUTHOR), Gutkind, J. Silvio7 (AUTHOR), Elkabets, Moshe1,2 (AUTHOR) moshee@bgu.ac.il
Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 11/20/2024, Vol. 43, p1-23. 23p.
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7
Akademický článek
Clinical Advances and Challenges in Targeting KRAS Mutations in Non-Small Cell Lung Cancer.
Autor: Dekker, Simone E.1,2 (AUTHOR) dekker@uw.edu, Deng, Lei1,2 (AUTHOR) ldeng1@fredhutch.org
Publikováno v: Cancers. Nov2024, Vol. 16 Issue 22, p3885. 12p.
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8
Akademický článek
RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms.
Autor: Yang, Xiaojuan1 (AUTHOR), Wu, Hong1,2 (AUTHOR) wuhong@scu.edu.cn
Publikováno v: Journal of Hematology & Oncology. 11/9/2024, Vol. 17 Issue 1, p1-31. 31p.
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9
Akademický článek
Unveiling the Promise: Navigating Clinical Trials 1978–2024 for PDAC.
Autor: Dominguez, Angel A.1 (AUTHOR) domingueza6@livemail.uthscsa.edu, Perz, Matthew T.1 (AUTHOR) perzm@livemail.uthscsa.edu, Xu, Yi1 (AUTHOR) xuy4@uthscsa.edu, Cedillo, Leonor G.1 (AUTHOR) leocedill@gmail.com, Huang, Orry D.1 (AUTHOR) orry.huang@utexas.edu, McIntyre, Caitlin A.2 (AUTHOR) mcintyrec1@uthscsa.edu, Vudatha, Vignesh3 (AUTHOR) vignesh.vudatha@vcuhealth.org, Trevino, Jose G.3 (AUTHOR) jose.trevino@vcuhealth.org, Liu, Jun1 (AUTHOR) liuj8@uthscsa.edu, Wang, Pei1 (AUTHOR) wangp3@uthscsa.edu
Publikováno v: Cancers. Nov2024, Vol. 16 Issue 21, p3564. 35p.
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10
Akademický článek
KRAS , a New Target for Precision Medicine in Colorectal Cancer?
Autor: Boilève, Alice1,2,3 (AUTHOR) alice.boileve@gustaveroussy.fr, Smolenschi, Cristina1,4 (AUTHOR) valerie.boige@gustaveroussy.fr, Lambert, Aurélien5 (AUTHOR) a.lambert@nancy.unicancer.fr, Boige, Valérie1 (AUTHOR) matthieu.delaye@gustaveroussy.fr, Delaye, Matthieu1 (AUTHOR) geraldine.camilleri@gustaveroussy.fr, Camilleri, Géraldine M.1 (AUTHOR) anthony.tarabay@gustaveroussy.fr, Tarabay, Anthony1 (AUTHOR) marine.valery@gustaveroussy.fr, Valéry, Marine1 (AUTHOR) alinacristina.fuerea@gustaveroussy.fr, Fuerea, Alina1 (AUTHOR) thomas.pudlarz@gustaveroussy.fr, Pudlarz, Thomas1 (AUTHOR) antoine.hollebecque@gustaveroussy.fr, Mathieu, Jacques R. R.2,3 (AUTHOR) fanny.jaulin@gustaveroussy.fr, Jaulin, Fanny2,3 (AUTHOR), Hollebecque, Antoine1,4 (AUTHOR) michel.ducreux@gustaveroussy.fr, Ducreux, Michel1,2 (AUTHOR)
Publikováno v: Cancers. Oct2024, Vol. 16 Issue 20, p3455. 16p.
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