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Akademický článek
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Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
The principal hormonal product of the thyroid gland, L-thyroxine (T4), is a prohormone for 3,3’,5-triiodo-L-thyronine, T3, the major ligand of nuclear thyroid hormone receptors (TRs). At a cell surface thyroid hormone analogue receptor on cancer ce
Externí odkaz:
https://doaj.org/article/6ce095d67c444bdb857b3b589c038141
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2023)
Thyroid hormone as L-thyroxine (T4) acts nongenomically at physiological concentrations at its cancer cell surface receptor on integrin αvβ3 (‘thyrointegrin’) to cause cancer cell proliferation. In the case of estrogen receptor (ERα)-positive
Externí odkaz:
https://doaj.org/article/fa616116676b4194aa1c9e0a4ffda641
Publikováno v:
Endocrine Research; Aug-Nov2024, Vol. 49 Issue 4, p251-254, 4p
Akademický článek
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Autor:
Yi-Fong Chen, Yung-Ning Yang, Hung-Ru Chu, Tung-Yung Huang, Shwu-Huey Wang, Han-Yu Chen, Zi-Lin Li, Yu-Chen S. H. Yang, Hung-Yun Lin, Aleck Hercbergs, Jacqueline Whang-Peng, Kuan Wang, Paul J. Davis
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Doxycycline, an antibiotic, displays the inhibition of different signal transduction pathways, such as anti-inflammation and anti-proliferation, in different types of cancers. However, the anti-cancer mechanisms of doxycycline via integrin αvβ3 are
Externí odkaz:
https://doaj.org/article/7e367beb7ba04f0dad4122e0b54844c9
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
L-Thyroxine (T4) is the principal ligand of the thyroid hormone analogue receptor on the extracellular domain of integrin αvβ3. The integrin is overexpressed and activated in cancer cells, rapidly dividing endothelial cells, and platelets. The biol
Externí odkaz:
https://doaj.org/article/eceb36dab1ba449887e9049ac55e8ede
Autor:
Gennadi V. Glinsky, Kavitha Godugu, Thangirala Sudha, Mehdi Rajabi, Sridar V. Chittur, Aleck A. Hercbergs, Shaker A. Mousa, Paul J. Davis
Publikováno v:
Metabolites, Vol 12, Iss 4, p 325 (2022)
Chemically modified forms of tetraiodothyroacetic acid (tetrac), an L-thyroxine derivative, have been shown to exert their anticancer activity at plasma membrane integrin αvβ3 of tumor cells. Via a specific hormone receptor on the integrin, tetrac-
Externí odkaz:
https://doaj.org/article/4bf6c93e6356488089aa326f217b96ea
Autor:
Elena Shinderman-Maman, Keren Cohen, Dotan Moskovich, Aleck Hercbergs, Haim Werner, Paul J. Davis, Martin Ellis, Osnat Ashur-Fabian
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Ovarian cancer is a highly aggressive disease and novel treatments are required. Thyroid hormones binding to αvβ3 integrin produced growth-promoting activities in ovarian cancer and we hypothesized that natural thyroid hormone derivatives
Externí odkaz:
https://doaj.org/article/0387e756b4e9437087dee0edd92fdf52
Autor:
Aleck Hercbergs
Publikováno v:
Frontiers in Endocrinology, Vol 10 (2019)
Hypothyroidism has been reported to improve survival in cancer patients but only recently has the putative mechanism been identified as a receptor for thyroxine and tri-iodothyronine on integrin αvβ3. Recognition of divergence of action of the pro-
Externí odkaz:
https://doaj.org/article/b3c8f02dc9ec4dc88a68b67249eb4ab5