Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Herbie Newell"'
Autor:
S Wedge, Roger J. Griffin, Maria Ahn, Karen Haggerty, Juan Castro, Ian R. Hardcastle, Celine Cano, Christopher N. Johnson, Bernard T. Golding, Herbie Newell, Steven Howard, Luke Bevan, Timothy J. Blackburn, Pamela A. Williams, Martin E.M. Noble, Yan Zhao, Judith Reeks, Ruth H. Bawn, Neil Thompson, Emiliano Tamanini, Ben Cons, Huw Thomas, Lynsey Fazal, Hugh Walton, Elaine Willmore, Sarah J. Cully, Gianni Chessari, Keisha Hearn, Ildiko Maria Buck
Publikováno v:
Cancer Research. 78:1652-1652
In response to cellular stress, the p53 tumor suppressor is activated to modulate cell cycle progression, DNA repair, and cell death. The activity of p53 is tightly regulated by MDM2, an E3 ubiquitin ligase that targets p53 for proteasomal degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f11828bba8837e5bc77a00d94f5218f
https://doi.org/10.1158/1538-7445.am2018-1652
https://doi.org/10.1158/1538-7445.am2018-1652
Publikováno v:
Cancer Research. 76:3701-3701
The tumour suppressor p53 is activated by cellular stress to induce cell cycle arrest and/or apoptosis. Although the TP53 gene is frequently mutated in cancer, approximately half of human cancers express wild type and functional p53. However, p53 act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db95c5771fcf6cde7f2a330881296b1d
https://doi.org/10.1158/1538-7445.am2016-3701
https://doi.org/10.1158/1538-7445.am2016-3701
Autor:
Rhona McMenemin, Herbie Newell, Elizabeth Ruth Plummer, Pete E Thelwall, Rakesh Heer, Piotr Pieniazek, Ross J. Maxwell, Ashraf Azzabi, Jim Snell, Jill McKenna, R. Pearson, Ian Pedley, J. Frew, Emily Louise Fitzgerald
Publikováno v:
Journal of Clinical Oncology. 34:403-403
403 Background: Functional imaging techniques which evaluate early treatment responses may identify non-responders who would benefit from a switch in therapy. This is a prospective feasibility study of serial diffusion-weighted (DW) and dynamic contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b960928210c5897a1cca5985c920cadc
https://doi.org/10.1200/jco.2016.34.2_suppl.403
https://doi.org/10.1200/jco.2016.34.2_suppl.403
Autor:
Edward A. Sausville, Herbie Newell
Publikováno v:
Cancer Chemotherapy and Pharmacology. 77:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a057f637d6c3e0502d4bdb830626533
https://doi.org/10.1007/s00280-015-2917-2
https://doi.org/10.1007/s00280-015-2917-2
Autor:
C.R. Coxon, Bernard T. Golding, Roger J. Griffin, John Lunec, H. Ahmed, J. Liu, IR Hardcastle, Herbie Newell, T. Blackburn, X. Lu
Publikováno v:
European Journal of Cancer Supplements. 8:139-140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b773d644b3baddee39629d14b9cb6dc
https://doi.org/10.1016/s1359-6349(10)72149-2
https://doi.org/10.1016/s1359-6349(10)72149-2
Publikováno v:
European Journal of Cancer. 45:319-320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c0e26058d0d400f1cbc48e15565dba4
https://doi.org/10.1016/j.ejca.2008.08.023
https://doi.org/10.1016/j.ejca.2008.08.023
Autor:
Herbie Newell, Ian Walker
Publikováno v:
Nature Reviews Drug Discovery. 8:15-16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb6d08dfb4e544a3a49fd01499857917
https://doi.org/10.1038/nrd2758
https://doi.org/10.1038/nrd2758
Publikováno v:
Cancer Chemotherapy and Pharmacology. 62:1115-1116
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d94ac1d929781ae0440dfa6fbbf63613
https://doi.org/10.1007/s00280-008-0824-5
https://doi.org/10.1007/s00280-008-0824-5
Autor:
Herbie Newell
Publikováno v:
European Journal of Cancer. 38:1163-1164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac11cfee7f0fe17b7728301b3784a85
https://doi.org/10.1016/s0959-8049(02)00088-6
https://doi.org/10.1016/s0959-8049(02)00088-6
Autor:
Nicola J. Curtin, Celine Cano, Herbie Newell, Bernard T. Golding, Graeme C. M. Smith, Roger J. Griffin, Ian R. Hardcastle
Publikováno v:
Molecular Cancer Therapeutics. 8:A138-A138
The cellular response to DNA double-strand break (DSB) formation is an essential component of normal cell survival, following exposure to DNA-damaging chemicals and ionising radiation. The serine/threonine kinase DNA-dependent protein kinase (DNA-PK)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58184771b168e6b0bbb01f0f74e146e
https://doi.org/10.1158/1535-7163.targ-09-a138
https://doi.org/10.1158/1535-7163.targ-09-a138