Zobrazeno 1 - 10
of 1 061
pro vyhledávání: '"Herbert Waldmann"'
Autor:
Lin Wang, Furkan Yilmaz, Okan Yildirim, Beate Schölermann, Sukdev Bag, Luca Greiner, Axel Pahl, Sonja Sievers, Rebecca Scheel, Carsten Strohmann, Christopher Squire, Daniel J. Foley, Slava Ziegler, Michael Grigalunas, Herbert Waldmann
Publikováno v:
Advanced Science, Vol 11, Iss 21, Pp n/a-n/a (2024)
Abstract The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linke
Externí odkaz:
https://doaj.org/article/9073737db646428dab117fefc2793b21
Autor:
Gang Xue, Jianing Xie, Matthias Hinterndorfer, Marko Cigler, Lara Dötsch, Hana Imrichova, Philipp Lampe, Xiufen Cheng, Soheila Rezaei Adariani, Georg E. Winter, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Targeted proteasomal and autophagic protein degradation, often employing bifunctional modalities, is a new paradigm for modulation of protein function. In an attempt to explore protein degradation by means of autophagy we combine arylidene-i
Externí odkaz:
https://doaj.org/article/8eb4dd1f4c7244f6a4e44f84f7729d66
Autor:
Lea Katharina Picard, Jens Alexander Niemann, Elisabeth Littwitz-Salomon, Herbert Waldmann, Carsten Watzl
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 5, p 2917 (2024)
Tumor cells rely heavily on glycolysis to meet their high metabolic demands. While this results in nutrient deprivation within the tumor microenvironment and has negative effects on infiltrating immune cells such as natural killer (NK) cells, it also
Externí odkaz:
https://doaj.org/article/96c9314d4f954734bced48da70a5c9b5
Autor:
Michael Grigalunas, Annina Burhop, Sarah Zinken, Axel Pahl, José-Manuel Gally, Niklas Wild, Yannik Mantel, Sonja Sievers, Daniel J. Foley, Rebecca Scheel, Carsten Strohmann, Andrey P. Antonchick, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Natural products inspire the development of pseudo-natural products through combinations of fragments of compound classes that are chemically and biologically distinct. Here, the authors report a library of 244 pseudo-natural products, evaluate them
Externí odkaz:
https://doaj.org/article/c324981d1dd847a2877255197701b2a3
Autor:
Hélène Adihou, Ranganath Gopalakrishnan, Tim Förster, Stéphanie M. Guéret, Raphael Gasper, Stefan Geschwindner, Carmen Carrillo García, Hacer Karatas, Ajaybabu V. Pobbati, Mercedes Vazquez‐Chantada, Paul Davey, Carola M. Wassvik, Jeremy Kah Sheng Pang, Boon Seng Soh, Wanjin Hong, Elisabetta Chiarparin, Dennis Schade, Alleyn T. Plowright, Eric Valeur, Malin Lemurell, Tom N. Grossmann, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Targeting the interaction between transcription factor TEAD and its co-repressor VGL4 is an attractive strategy to chemically modulate Hippo signaling. Here, the authors develop a proteomimetic with stabilized tertiary structure that inhibits the TEA
Externí odkaz:
https://doaj.org/article/34105208594045348e3822ea97b488f7
Autor:
Annina Burhop, Sukdev Bag, Michael Grigalunas, Sophie Woitalla, Pia Bodenbinder, Lukas Brieger, Carsten Strohmann, Axel Pahl, Sonja Sievers, Herbert Waldmann
Publikováno v:
Advanced Science, Vol 8, Iss 19, Pp n/a-n/a (2021)
Abstract Chemical and biological limitations in bioactive compound design based on natural product (NP) structure can be overcome by the combination of NP‐derived fragments in unprecedented arrangements to afford “pseudo‐natural products” (ps
Externí odkaz:
https://doaj.org/article/a5433ad5b1774617bf71389cc24b604b
Publikováno v:
Cells, Vol 11, Iss 21, p 3489 (2022)
Tumor cells often have very high energy demands. Inhibition of glucose uptake is therefore a possible approach to limit the proliferation and survival of transformed cells. However, immune cells also require energy to initiate and to maintain anti-tu
Externí odkaz:
https://doaj.org/article/c3614347d4894c15a017f4988b791595
Autor:
Arancha López-Pérez, Stefan Freischem, Immanuel Grimm, Oliver Weiergräber, Andrew J. Dingley, María Pascual López-Alberca, Herbert Waldmann, Waldemar Vollmer, Kamal Kumar, Cuong Vuong
Publikováno v:
Antibiotics, Vol 10, Iss 5, p 529 (2021)
The alarming threat of the spread of multidrug resistant bacteria currently leaves clinicians with very limited options to combat infections, especially those from Gram-negative bacteria. Hence, innovative strategies to deliver the next generation of
Externí odkaz:
https://doaj.org/article/b7bee0b11258463ba2d0f3430dc435d5
Autor:
Yen-Chun Lee, Sumersing Patil, Christopher Golz, Carsten Strohmann, Slava Ziegler, Kamal Kumar, Herbert Waldmann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Synthetic methods that efficiently construct structurally diverse molecular scaffolds are attractive routes to diversely bioactive molecules. Here the authors report a method whereby common starting materials are converted to structurally and functio
Externí odkaz:
https://doaj.org/article/d1bf46a4d848459f9c5dd08e325677dc
Autor:
Kirsten Tschapalda, Ya-Qin Zhang, Li Liu, Kseniya Golovnina, Thomas Schlemper, Thomas O. Eichmann, Madhu Lal-Nag, Urmila Sreenivasan, John McLenithan, Slava Ziegler, Carole Sztalryd, Achim Lass, Douglas Auld, Brian Oliver, Herbert Waldmann, Zhuyin Li, Min Shen, Matthew B. Boxer, Mathias Beller
Publikováno v:
EBioMedicine, Vol 8, Iss C, Pp 49-59 (2016)
Excess lipid storage is an epidemic problem in human populations. Thus, the identification of small molecules to treat or prevent lipid storage-related metabolic complications is of great interest. Here we screened >320.000 compounds for their abilit
Externí odkaz:
https://doaj.org/article/6d353b3c4e674fdc8ba176664da784f4