Zobrazeno 1 - 10
of 339
pro vyhledávání: '"Herbert W Virgin"'
Autor:
Lisa K McLellan, Michael R McAllaster, Arthur S Kim, Ľubomíra Tóthová, Patrick D Olson, Jerome S Pinkner, Allyssa L Daugherty, Teri N Hreha, James W Janetka, Daved H Fremont, Scott J Hultgren, Herbert W Virgin, David A Hunstad
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009314 (2021)
Type 1 pili have long been considered the major virulence factor enabling colonization of the urinary bladder by uropathogenic Escherichia coli (UPEC). The molecular pathogenesis of pyelonephritis is less well characterized, due to previous limitatio
Externí odkaz:
https://doaj.org/article/7065da0da0334adc82256aacbadafc8d
Autor:
Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin
Publikováno v:
PLoS Pathogens, Vol 13, Iss 2, p e1006223 (2017)
[This corrects the article DOI: 10.1371/journal.ppat.1005684.].
Externí odkaz:
https://doaj.org/article/6e89a54d79ce4a1db5b0b3e9e035bf66
Autor:
Timothy J Nice, Lisa C Osborne, Vesselin T Tomov, David Artis, E John Wherry, Herbert W Virgin
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005684 (2016)
In order for a virus to persist, there must be a balance between viral replication and immune clearance. It is commonly believed that adaptive immunity drives clearance of viral infections and, thus, dysfunction or viral evasion of adaptive immunity
Externí odkaz:
https://doaj.org/article/b4e5a4a498b34c6990fa1a2062e42898
Autor:
Donna A MacDuff, Tiffany A Reese, Jacqueline M Kimmey, Leslie A Weiss, Christina Song, Xin Zhang, Amal Kambal, Erning Duan, Javier A Carrero, Bertrand Boisson, Emmanuel Laplantine, Alain Israel, Capucine Picard, Marco Colonna, Brian T Edelson, L David Sibley, Christina L Stallings, Jean-Laurent Casanova, Kazuhiro Iwai, Herbert W Virgin
Publikováno v:
eLife, Vol 4 (2015)
Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors. Patients with mutations in HOIL1 (RBCK1) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immu
Externí odkaz:
https://doaj.org/article/f941c4f63123408d9501b761e744694d
Autor:
Helen M Lazear, Alissa Lancaster, Courtney Wilkins, Mehul S Suthar, Albert Huang, Sarah C Vick, Lisa Clepper, Larissa Thackray, Margaret M Brassil, Herbert W Virgin, Janko Nikolich-Zugich, Ashlee V Moses, Michael Gale, Klaus Früh, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 9, Iss 1, p e1003118 (2013)
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3(-/-)×Irf7(-/-) double knockout (DKO) myeloid dendritic cells (mDC) produce relati
Externí odkaz:
https://doaj.org/article/0258aaa646b143a08b6aba9fa6b533b4
Autor:
Guoyan Zhao, Siddharth Krishnamurthy, Zhengqiu Cai, Vsevolod L Popov, Amelia P Travassos da Rosa, Hilda Guzman, Song Cao, Herbert W Virgin, Robert B Tesh, David Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78470 (2013)
Quick and accurate identification of microbial pathogens is essential for both diagnosis and response to emerging infectious diseases. The advent of next-generation sequencing technology offers an unprecedented platform for rapid sequencing-based ide
Externí odkaz:
https://doaj.org/article/6ace77934d7e4fed9a4f51c776eb0d15
Autor:
Elizabeth M Selleck, Sarah J Fentress, Wandy L Beatty, Daniel Degrandi, Klaus Pfeffer, Herbert W Virgin, John D Macmicking, L David Sibley
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003320 (2013)
IFN-γ activates cells to restrict intracellular pathogens by upregulating cellular effectors including the p65 family of guanylate-binding proteins (GBPs). Here we test the role of Gbp1 in the IFN-γ-dependent control of T. gondii in the mouse model
Externí odkaz:
https://doaj.org/article/3601eeaff5324cb183ded6647a5fffd4
Autor:
Volker Fensterl, Jaime L Wetzel, Srividya Ramachandran, Tomoaki Ogino, Stephen A Stohlman, Cornelia C Bergmann, Michael S Diamond, Herbert W Virgin, Ganes C Sen
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002712 (2012)
Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. A prominent family of ISGs is the interferon-ind
Externí odkaz:
https://doaj.org/article/d191922ab43f4348a2bf0ac7c77f8bd9
Autor:
Kristy J Szretter, Brian P Daniels, Hyelim Cho, Maria D Gainey, Wayne M Yokoyama, Michael Gale, Herbert W Virgin, Robyn S Klein, Ganes C Sen, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 8, Iss 5, p e1002698 (2012)
Prior studies have shown that 2'-O methyltransferase activity of flaviviruses, coronaviruses, and poxviruses promotes viral evasion of Ifit1, an interferon-stimulated innate immune effector protein. Viruses lacking 2'-O methyltransferase activity exh
Externí odkaz:
https://doaj.org/article/791cda7ce65d4052bb76e27b424652f6
Autor:
Nicole Meyer-Morse, Jennifer R Robbins, Chris S Rae, Sofia N Mochegova, Michele S Swanson, Zijiang Zhao, Herbert W Virgin, Daniel Portnoy
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8610 (2010)
Recent studies have suggested that autophagy is utilized by cells as a protective mechanism against Listeria monocytogenes infection.However we find autophagy has no measurable role in vacuolar escape and intracellular growth in primary cultured bone
Externí odkaz:
https://doaj.org/article/dad4250e5fa1470d9d2460553f5e6cea