Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Herbert Struemper"'
Autor:
Jon Collins, Martijn vanNoort, Chetan Rathi, Teun M. Post, Herbert Struemper, Roxanne C. Jewell, Geraldine Ferron‐Brady
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1411-1424 (2023)
Abstract Belantamab mafodotin, a monomethyl auristatin F (MMAF)–containing monoclonal antibody‐drug conjugate (ADC), demonstrated deep and durable responses in the DRiving Excellence in Approaches to Multiple Myeloma (DREAMM)‐1 and pivotal DREA
Externí odkaz:
https://doaj.org/article/64f0679dba8e4c4f849660f10b215699
Autor:
Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 11, Pp 2625-2639 (2022)
Abstract A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll‐like receptor 4 (TLR4) agonist, in combination with immunotherapy (GSK3174998 [anti‐OX40 monoclonal antibody], GSK3359609 [anti‐ICOS monoclon
Externí odkaz:
https://doaj.org/article/49c13d90d7e24ea0911654cd99a602a9
Autor:
Stephane Champiat, Aurélien Marabelle, Anna Spreafico, Mehmet Altan, Todd M Bauer, Osama Rahma, Karen A Autio, Neeta Somaiah, Meredith McKean, Aaron R Hansen, Jan H M Schellens, Willeke Ros, F Stephen Hodi, Jeffrey S Weber, John V Heymach, Herbert Struemper, Sandrine Aspeslagh, Daniel C Cho, Jennifer K Litton, Axel Hoos, Vincent K Lam, Emmett V Schmidt, Sophie Postel-Vinay, Frans L Opdam, Elaine M Paul, Christoph M Ahlers, Helen Zhou, Shelby A Gorman, Maura Watmuff, Kaitlin M Yablonski, Niranjan Yanamandra, Michael J Chisamore
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 3 (2023)
Background The phase I first-in-human study ENGAGE-1 evaluated the humanized IgG1 OX40 agonistic monoclonal antibody GSK3174998 alone (Part 1 (P1)) or in combination with pembrolizumab (Part 2 (P2)) in patients with advanced solid tumors.Methods GSK3
Externí odkaz:
https://doaj.org/article/cede222f65c649b89ade485245fc9ae7
Autor:
Chetan Rathi, Jon Collins, Herbert Struemper, Joanna Opalinska, Roxanne C. Jewell, Geraldine Ferron‐Brady
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 851-863 (2021)
Abstract Belantamab mafodotin (belamaf) is an antibody–drug conjugate (ADC) targeting B‐cell maturation antigen (BCMA). Nonlinear mixed‐effects models were developed to characterize the population pharmacokinetics (PopPK) of ADC, total monoclon
Externí odkaz:
https://doaj.org/article/54aded09da294383a33b92e887443362
Autor:
William Stohl, Milena Kurtinecz, David A Roth, Herbert Struemper, William W Freimuth, Lisa Edwards
Publikováno v:
Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/22de3cc72bf2458aa9500f454d153a48
Autor:
Anders Österborg, Roxanne C. Jewell, Swami Padmanabhan-Iyer, Thomas J. Kipps, Jiří Mayer, Stephan Stilgenbauer, Cathy D. Williams, Andrzej Hellmann, Richard R. Furman, Tadeusz Robak, Peter Hillmen, Marek Trnêný, Martin J.S. Dyer, Magdalena Piotrowska, Tomas Kozak, Ira V. Gupta, Jennifer L. Phillips, Nancy Goldstein, Herbert Struemper, Nedjad Losic, Steen Lisby, William G. Wierda
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Externí odkaz:
https://doaj.org/article/19adce254e934f14a1055ceca752c298
Autor:
Neeltje Steeghs, Aaron R. Hansen, Glenn J. Hanna, Elena Garralda, Haeseong Park, James Strauss, Michael Adam, Gossett Campbell, Jennifer Carver, Rachael Easton, Katherine Mays, Peter Skrdla, Herbert Struemper, Michael L. Washburn, Christopher Matheny, Sarina A. Piha‐Paul
Publikováno v:
Scientia
Biological activity; Solid tumors Actividad biológica; Tumores sólidos Activitat biològica; Tumors sòlids A phase I trial (NCT03447314; 204686) evaluated the safety and efficacy of GSK1795091, a Toll-like receptor 4 (TLR4) agonist, in combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52a2c776e6853dfc712d9d3e7b04e11
https://doi.org/10.1111/cts.13387
https://doi.org/10.1111/cts.13387
Autor:
George Coukos, John Toso, Olivia Gardner, Zdenka Jonak, Fiona Germaschewski, Herbert Struemper, John Bauman, Sharon Murray, Joseph Lucci, Jonathan S. Berek, Christina Chu, Aurea Flores, Fiona Simpkins
PDF file - 46K, Patient Demographics and Disease Characteristics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e77143fea3f9dbdd5afa51c5962a793
https://doi.org/10.1158/2326-6066.22536254
https://doi.org/10.1158/2326-6066.22536254
Autor:
George Coukos, John Toso, Olivia Gardner, Zdenka Jonak, Fiona Germaschewski, Herbert Struemper, John Bauman, Sharon Murray, Joseph Lucci, Jonathan S. Berek, Christina Chu, Aurea Flores, Fiona Simpkins
Recombinant interleukin (IL)-18 (SB-485232) is an immunostimulatory cytokine, with shown antitumor activity in combination with pegylated liposomal doxorubicin (PLD) in preclinical models. This phase I study evaluated the safety, tolerability, and bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1171759281cb4c8575387ed6c21c9440
https://doi.org/10.1158/2326-6066.c.6548087.v1
https://doi.org/10.1158/2326-6066.c.6548087.v1
Autor:
Jon L. Collins, Roxanne C. Jewell, Herbert Struemper, Chetan Rathi, Geraldine Ferron-Brady, Joanna Opalinska
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 851-863 (2021)
CPT: Pharmacometrics & Systems Pharmacology, Vol 10, Iss 8, Pp 851-863 (2021)
Belantamab mafodotin (belamaf) is an antibody-drug conjugate (ADC) targeting B-cell maturation antigen (BCMA). Nonlinear mixed-effects models were developed to characterize the population pharmacokinetics (PopPK) of ADC, total monoclonal antibody (mA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1be701882d49460ffbb290706ba28a9
https://doi.org/10.1002/psp4.12660
https://doi.org/10.1002/psp4.12660