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pro vyhledávání: '"Herbert S. Rosenkranz"'
Publikováno v:
Carcinogenicity ISBN: 9781003067641
Carcinogenicity
Carcinogenicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45998acb3a94ae510a830b9c16bb9f56
https://doi.org/10.1201/9781003067641-9
https://doi.org/10.1201/9781003067641-9
Publikováno v:
Alternatives to Laboratory Animals. 33:9-19
The relationship between acute toxicity in rats (LD50 values) and indicators of potential health hazards in humans was investigated, based on a chemical population-based paradigm (i.e. the “chemical diversity approach”). These structure–activit
Autor:
Herbert S. Rosenkranz
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 559:67-71
SAR approaches to the study of genotoxic phenomena are finding increased applications. However, the data being modeled are frequently not considered optimal due to the small size of the dataset and an uneven distribution of genotoxicants and non-geno
Publikováno v:
Science of The Total Environment. 313:15-24
Using the recently developed and validated 'chemical diversity approach', the potential of chemicals, to be detected by the human olfactory system and to cause adverse health effects, was investigated. The analyses found no significant association be
Autor:
Herbert S. Rosenkranz
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 529:117-127
The health risk manager and policy analyst must frequently make recommendations based upon incomplete toxicity data. This is a situation which is encountered in the evaluation of human carcinogenic risks as animal cancer bioassay results are often no
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 528:81-91
A "chemical population"-based investigation of xenobiotics (i.e. a sample of 10,000 chemicals representative of agents in commerce, industry, and the environment, both synthetic and natural) that have the potential for ecotoxicity because of their pe
Autor:
Herbert S. Rosenkranz
Publikováno v:
Alternatives to Laboratory Animals. 31:393-399
The increased acceptance of the use of structure–activity relationship (SAR) approaches to toxicity modelling has necessitated an evaluation of the limitations of the methodology. In this study, the limit of the capacity of the MULTICASE SAR progra
Autor:
Herbert S. Rosenkranz, A R Cunningham
Publikováno v:
SAR and QSAR in Environmental Research. 14:215-222
The ability of human to perceive odors is a very complex phenomenon involving the selective binding of molecules to approximately 1000 olfactory receptors. Accordingly, the derivation of a substructure-based SAR model can be expected to be problemati
Autor:
Herbert S. Rosenkranz
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Currently available substructure-based structure-activity relationship (SAR) methodologies, if expertly used, can be employed to predict the toxicological potential of therapeutic agents. Moreover, with robust SAR models of toxicological phenomena, i
Autor:
Herbert S. Rosenkranz, Xinyu Zhu
Publikováno v:
Alternatives to laboratory animals : ATLA. 28(4)
A coherent structure-activity relationship (SAR) model was derived from data based on the toxicity of chemicals in cultured human HeLa cells. The ability to construct such a model indicates that toxicity is a function of a finite number of mechanisms