Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Herbert Oguto"'
Autor:
Haris Jahic, Kerry E. Murphy-Benenato, P. Ann Boriack-Sjodin, Dan Carcanague, Jenna Harang, Tina Howard, Claire Brassington, Madhusudhan Reddy Gowravaram, Charles J. Eyermann, Lakshmaiah Gingipalli, Herbert Oguto, Sahil Patel, Robert A. Giacobbe, Ludovic Otterbein, Amy Kutschke, James T. Loch, Georgine Ioannidis, Valerie A. Laganas, Michael R. Hale, Adam B. Shapiro, Kevin J. Embrey, Matthew D. Miller
Publikováno v:
Tetrahedron Letters. 56:3108-3112
Bacterial NAD+-dependent DNA ligase (LigA) is an essential enzyme involved in the repair, replication, and recombination of DNA in all bacteria, making it an attractive target in antibacterial drug discovery. A novel series of LigA inhibitors was dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fe2683d6839ef615d9bfebf560d10c8
https://doi.org/10.1016/j.tetlet.2014.12.067
https://doi.org/10.1016/j.tetlet.2014.12.067
Autor:
P. Ann Boriack-Sjodin, Lakshmaiah Gingipalli, Madhu Gowravaram, Amy Kutschke, Herbert Oguto, Kerry E. Murphy-Benenato, Sahil Patel, James T. Loch, Michele Johnstone, Dan Carcanague, Charles J. Eyermann, Matthew D. Miller, Harris Jahic, Gabriel Martínez-Botella, Georgine Ioannidis, Valerie A. Laganas, Jenna Harang, Michael R. Hale
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(22)
Two novel compounds, pyridopyrimidines (1) and naphthyridines (2) were identified as potent inhibitors of bacterial NAD(+)-dependent DNA ligase (Lig) A in a fragment screening. SAR was guided by molecular modeling and X-ray crystallography. It was ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c0423dc15e4224bbd8ca0095c379d
https://pubmed.ncbi.nlm.nih.gov/26463129
https://pubmed.ncbi.nlm.nih.gov/26463129