Zobrazeno 1 - 10
of 603
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Emile Farah, Andres A. Abreu, Benjamin Rail, Javier Salgado, Georgios Karagkounis, Herbert J. Zeh, Patricio M. Polanco
Publikováno v:
World Journal of Surgical Oncology, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background Robotic colorectal surgery is becoming the preferred surgical approach for colorectal cancer (CRC). It offers several technical advantages over conventional laparoscopy that could improve patient outcomes. In this retrospective co
Externí odkaz:
https://doaj.org/article/0a0ba0eaffa54e8994b796503fd2c851
Autor:
John D. Karalis, Lynn Y. Yoon, Suntrea T. G. Hammer, Changjin Hong, Min Zhu, Ibrahim Nassour, Michelle R. Ju, Shu Xiao, Esther C. Castro-Dubon, Deepak Agrawal, Jorge Suarez, Scott I. Reznik, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh, Tae Hyun Hwang, Hao Zhu, Matthew R. Porembka, Sam C. Wang
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monot
Externí odkaz:
https://doaj.org/article/eefb831987264d6b88bacc7638ab3ccd
Autor:
Ke Liu, Jiao Liu, Borong Zou, Changfeng Li, Herbert J. Zeh, Rui Kang, Guido Kroemer, Jun Huang, Daolin Tang
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Background & Aims: Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a se
Externí odkaz:
https://doaj.org/article/20619a1005814013b50f7128b03ee9bc
Autor:
Samer S. AlMasri, Mazen S. Zenati, Annissa Desilva, Ibrahim Nassour, Brian A. Boone, Aatur D. Singhi, David L. Bartlett, Lance A. Liotta, Virginia Espina, Patricia Loughran, Michael T. Lotze, Alessandro Paniccia, Herbert J. Zeh III, Amer H. Zureikat, Nathan Bahary
Publikováno v:
Cancer Medicine, Vol 10, Iss 20, Pp 7233-7241 (2021)
Abstract Introduction Preoperative autophagy inhibition with hydroxychloroquine (HCQ) in combination with gemcitabine in pancreatic adenocarcinoma (PDAC) has been shown to be safe and effective in inducing a serum biomarker response and increase rese
Externí odkaz:
https://doaj.org/article/22bcc880a5264081a326a90968f1c5d6
Autor:
Naomi Fei, Sijin Wen, Rajesh Ramanathan, Melissa E. Hogg, Amer H. Zureikat, Michael T. Lotze, Nathan Bahary, Aatur D. Singhi, Herbert J. Zeh, Brian A. Boone
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 5, Pp 1822-1829 (2021)
Abstract SMAD4, a tumor suppressor gene, is lost in up to 60%–90% of pancreatic adenocarcinomas (PDAs). Loss of SMAD4 allows tumor progression by upregulating autophagy, a cell survival mechanism that counteracts apoptosis and allows intracellular
Externí odkaz:
https://doaj.org/article/fc1b523b0b3a44e2a592d00a88565d98
Autor:
Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, Herbert J. Zeh, Rui Kang, Lulu Bai, Daolin Tang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Ferroptosis is an iron-dependent mechanism of cell death. In this mouse study, the authors show that diets high in iron or depletion of the antioxidant Gpx4 potentiates pancreatic damage and tumour formation by activating the DNA damage pathway and r
Externí odkaz:
https://doaj.org/article/c121a8ce021a465cb09de4318e23669d
Autor:
Xinxin Song, Jiao Liu, Feimei Kuang, Xin Chen, Herbert J. Zeh, III, Rui Kang, Guido Kroemer, Yangchun Xie, Daolin Tang
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108767- (2021)
Summary: Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly elucidated. Here, we show that glucose determines the sensi
Externí odkaz:
https://doaj.org/article/2275ec8fa8824df9918532d28b450b92
Autor:
Ruochan Chen, Yan Huang, Jun Quan, Jiao Liu, Haichao Wang, Timothy R. Billiar, Michael T. Lotze, Herbert J. Zeh, Rui Kang, Daolin Tang
Publikováno v:
Heliyon, Vol 6, Iss 12, Pp e05672- (2020)
COVID-19 has attracted global attention due to its rapid spread around the world with substantial morbidity and associated mortality. Severe COVID-19 can be complicated by the acute respiratory distress syndrome, sepsis and septic shock leading to de
Externí odkaz:
https://doaj.org/article/112eb292af994e4c8403b33ef38c5dff
Autor:
Prakash C. Thakur, Jennifer L. Miller-Ocuin, Khanh Nguyen, Rina Matsuda, Aatur D. Singhi, Herbert J. Zeh, Nathan Bahary
Publikováno v:
Journal of Translational Medicine, Vol 16, Iss 1, Pp 1-19 (2018)
Abstract Background Endoplasmic reticulum (ER) stress and its consequent unfolded protein response (UPR) are believed to be associated with progression, survival and chemoresistance of a variety of tumor cells through multiple cellular processes, inc
Externí odkaz:
https://doaj.org/article/f5a6e74185584c37ac1fa200cd70bc24
Autor:
Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal, Herbert J. Zeh
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-12 (2018)
Abstract Background The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular traps (NETs), whereb
Externí odkaz:
https://doaj.org/article/7bb851ee267642998fc7ef74c6f8bd4d