Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Herbert J. Brabander"'
Autor:
Gerardo D. Francisco, Herbert J. Brabander, Richard M. Mangano, Richard H. Kramss, Eugene J. Trybulski
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:827-832
The synthesis and radioligand binding data of optically active hydroxylated oxotremorine derivatives are described. These are significant pharmacological differences between the enantiomers, most notably at the 3- and 4-position of the pyrrolidinone
Publikováno v:
Journal of Heterocyclic Chemistry. 24:837-843
2-Aminobenzimidazoles were reacted with enaminones in acetic acid to give pyrimido[1,2-a]benzimidazoles. With a substituted enaminone only one regioisomer was obtained. Structural assignments based on nmr and uv spectroscopy are presented. Possible p
Autor:
Arnold C. Osterberg, F. M. Lovell, Thomas C. McKenzie, Herbert J. Brabander, Corris M. Hofmann, D. B. Cosulich, Epstein Joseph William, Sidney R. Safir, William J. Fanshawe
Publikováno v:
Journal of Medicinal Chemistry. 24:481-490
A series of 1-aryl-3-azabicyclo[3.1.0]hexanes was synthesized by hydride reduction of 1-arylcyclopropanedicarboximides. Hydroxyphenyl analogues 20, 22, and 24 were prepared by EtSNa--DMF ether cleavage of the corresponding methoxyphenyl analogues 2m,
Publikováno v:
The Journal of Organic Chemistry. 26:4057-4060
Publikováno v:
The Journal of Organic Chemistry. 26:2120-2123
Publikováno v:
Journal of the American Chemical Society. 81:5637-5640
Publikováno v:
The Journal of Organic Chemistry. 26:4051-4057
Publikováno v:
Journal of Medicinal Chemistry. 9:852-857
Publikováno v:
Journal of Heterocyclic Chemistry. 2:130-135
The synthesis of 8-tert-aminoalkoxy-6-aryl-6,7-diazaspiro[3.4]oct-7-en-5-ones (1) and 6-tert-aminoalkyl-7-aryl-6,7-diazaspiro[3.4]octane-5,8-diones has been accomplished. Two synthetic methods are described, each of which yields principally one isome
Publikováno v:
The Journal of Organic Chemistry. 26:485-490