Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Herbert Hoyer"'
Publikováno v:
Journal of drug delivery science and technology, 20(3), 181-186. Editions de Sante
Among mucoadhesive polymers, thiolated polymers showed to be superior over non-thiolated polymers. Recently a novel thiolated chitosan named chitosan-6-mercaptonicotinamide has been generated. Its heteroaromatic structure confers a pH-independent rea
Publikováno v:
Drug Development and Industrial Pharmacy. 36:31-44
The aim of this review is to provide the reader general and inspiring prospects in various attempts to make noninvasive delivery systems of calcitonin and teriparatide feasible and as convenient as possible.Calcitonin and teriparatide play an importa
Publikováno v:
Journal of Pharmaceutical Sciences. 98:620-627
A new oral patch delivery system has been designed to increase the overall oral bioavailability of drugs within the gastrointestinal tract. The patch system consists of four layered films: a mucoadhesive matrix layer, a water insoluble backing layer,
Publikováno v:
Drug Development and Industrial Pharmacy. 35:209-215
Mucoadhesive drug delivery systems offer promising opportunities for oral drug delivery. The aim of this study was to investigate the feasibility of preparing liposomes that are coated with the multifunctional polymer poly(acrylic acid)-cysteine (PAA
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 69:476-485
Microparticles were formulated by incorporation of the model protein horseradish peroxidase in (thiolated) chitosan and (thiolated) poly(acrylic acid) via co-precipitation. Dried protein/polymer complexes were ground with an air jet mill and resultin
Autor:
Martin Werle, Martin H. Hoffer, Krum Kafedjiiski, Ram K. R. Jetti, Andreas Bernkop-Schnürch, Florian Föger, Herbert Hoyer
Publikováno v:
International Journal of Pharmaceutics. 343:48-58
It was the aim of this study to synthesize and characterize a novel hyaluronic acid-cysteine ethyl ester (HA-Cys) conjugate providing improved mucoadhesive properties and a significantly lowered biodegradation rate. Mediated by carbodiimide and N-hyd
Publikováno v:
Drug Development and Industrial Pharmacy. 33:199-208
The aim of this study was to examine the biodegradability of thiomers and cross-linked thiomers in comparison with unmodified polymers. Disulfide-cross-linked conjugates were prepared by air oxidation at room temperature. Thiomers were investigated b
Publikováno v:
Drug Development and Industrial Pharmacy. 33:1289-1296
Within this study, a novel gastrointestinal patch system was developed and investigated regarding water-absorbing capacity, adhesive properties, in vitro release, unidirectional release and permeation enhancing effect. Water uptake studies revealed t
Publikováno v:
Journal of Drug Targeting. 15:132-139
It was the aim of this study to investigate the effect of chitosan-4-thiobutylamidine (Ch-TBA) and reduced glutathione (GSH) on the absorption of P-glycoprotein (P-gp) and multidrug resistance protein (MRP) substrate saquinavir in vitro and in vivo.