Výsledky vyhledávání - "Herbert, Kim"

Akademický článek

Synchronized autologous T-cell immunotherapy with hyperthermia to previously heavy treated advanced renal cell carcinoma

Autor: Jun Ren, Congcong Li, Dazhao Xu, Kun Wan, Chuxiong Zeng, Lina Hu, Xianzhi Guo, Feifei Huo, Xiumei Rong, Xinna Zhou, Tiecheng Wu, Xiaoli Wang, Bo Sun, JingJing Lou, Amy Hobeika, Michael A. Morse, Herbert Kim Lyerly

Publikováno v: International Journal of Hyperthermia, Vol 41, Iss 1 (2024)

Purpose Immune checkpoint inhibitors (ICIs) and target therapy have provided the clinical efficacy for improving the clinical progression-free survival (PFS) and overall survival (OS) for patients with renal cell carcinoma (RCC). There has been littl

Externí odkaz: https://doaj.org/article/bc311b8df66144a488149fa33a320674

Zobrazit plný text záznamu

Akademický článek

Vaccination Against Androgen Receptor Splice Variants to Immunologically Target Prostate Cancer

Autor: Robert D. Marek, Selena Halabi, Mu-En Wang, Jason McBane, Junping Wei, Tao Wang, Xiao Yang, Congxiao Liu, Gangjun Lei, Herbert Kim Lyerly, Ming Chen, Timothy N. Trotter, Zachary C. Hartman

Publikováno v: Vaccines, Vol 12, Iss 11, p 1273 (2024)

Background/Objectives: Androgen receptor (AR) expression and signaling are critical for the progression of prostate cancer and have been the therapeutic focus of prostate cancer for over 50 years. While a variety of agents have been developed to targ

Externí odkaz: https://doaj.org/article/c963995c0b8d4b7f83e39d65de5281db

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Combination of a novel heat shock protein 90-targeted photodynamic therapy with PD-1/PD-L1 blockade induces potent systemic antitumor efficacy and abscopal effect against breast cancers

Autor: Xiao Yang, Michael A Morse, Takuya Osada, Amy Hobeika, Herbert Kim Lyerly, Zachary Conrad Hartman, Hiroshi Nagata, Kensuke Kaneko, Chaitanya R Acharya, Philip F Hughes, Timothy A J Haystead

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 9 (2022)

Background We previously demonstrated potent antitumor activity against human breast cancer xenografts using photodynamic therapy (PDT) targeting a novel tumor-specific photosensitizer (HS201), which binds heat shock protein 90 (HS201-PDT). However,

Externí odkaz: https://doaj.org/article/565e94da5b9048f6b975c2f576e21cce

Zobrazit plný text záznamu

Akademický článek

Action for Increasing Diversity, Market Access, and Capacity in Oncology Registration Trials—Is Africa the Answer? Report From a Satellite Session of the Accelerating Anti-Cancer Agent Development and Validation Workshop

Autor: Darya Kizub, Cathyryne K. Manner, Katy Graef, Bello Abubakar, Jackson Orem, Folakemi Odedina, Mojisola Christianah Adeyeye, Gertrude Nakigudde, Kassa Ayalew, Chitkala Kalidas, Herbert Kim Lyerly, Thea Norman, Lola Fashoyin-Aje, Jamie Freedman, Jennifer Dent, Bill Cance, Julie Gralow

Publikováno v: JCO Global Oncology, Vol , Iss 8 (2022)

Patients of African ancestry are not well-represented in cancer clinical trials despite bearing a disproportionate share of mortality both in United States and Africa. We describe key stakeholder perspectives and priorities related to bringing early-

Externí odkaz: https://doaj.org/article/c70bdb1e2e38445683572079d0ce2509

Zobrazit plný text záznamu

Akademický článek

Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis

Autor: Li-Chung Tsao, Erika J. Crosby, Timothy N. Trotter, Junping Wei, Tao Wang, Xiao Yang, Amanda N. Summers, Gangjun Lei, Christopher A. Rabiola, Lewis A. Chodosh, William J. Muller, Herbert Kim Lyerly, Zachary C. Hartman

Publikováno v: JCI Insight, Vol 7, Iss 6 (2022)

Two HER2-specific mAbs, trastuzumab and pertuzumab (T+P), combined with chemotherapy comprise standard-of-care treatment for advanced HER2+ breast cancers (BC). While this antibody combination is highly effective, its synergistic mechanism-of-action

Externí odkaz: https://doaj.org/article/c87d5137315e42528a934056270a6891

Zobrazit plný text záznamu

Akademický článek

Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Autor: Tao Wang, Michael A Morse, Takuya Osada, Herbert Kim Lyerly, Junping Wei, Xiao-Yi Yang, Gangjun Lei, Zachary Conrad Hartman, Pankaj Agarwal, Li-Chung Tsao, Chaitanya R Acharya, Bin-Jin Hwang, Timothy Trotter

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)

Background The majority of colorectal carcinomas (CRCs) are insensitive to programmed death protein-1/programmed death-ligand 1 (anti-PD-1/PD-L1) immune checkpoint inhibitor (ICI) antibodies. While there are many causes for ICI insensitivity, recent

Externí odkaz: https://doaj.org/article/7313de08ca68445aa4436a03e31eed63

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání