Výsledky vyhledávání - "Herberg, Maria"

Akademický článek

Epigenetic Drifts during Long-Term Intestinal Organoid Culture

Autor: Thalheim, Torsten, Siebert, Susann, Quaas, Marianne, Herberg, Maria, Schweiger, Michal R., Aust, Gabriela, Galle, Joerg

Organoids retain the morphological and molecular patterns of their tissue of origin, are self-organizing, relatively simple to handle and accessible to genetic engineering. Thus, they represent an optimal tool for studying the mechanisms of tissue ma

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A85120
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Akademický článek

Fighting Against Promoter DNA Hyper-Methylation: Protective Histone Modification Profiles of Stress-Resistant Intestinal Stem Cells

Autor: Thalheim, Torsten, Hopp, Lydia, Herberg, Maria, Siebert, Susann, Kerner, Christiane, Quaas, Marianne, Schweiger, Michal R., Aust, Gabriela, Galle, Joerg

Aberrant DNA methylation in stem cells is a hallmark of aging and tumor development. Recently, we have suggested that promoter DNA hyper-methylation originates in DNA repair and that even successful DNA repair might confer this kind of epigenetic lon

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A88784
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Akademický článek

The Regulatory Capacity of Bivalent Genes: A Theoretical Approach

Autor: Thalheim, Torsten, Herberg, Maria, Löffler, Markus, Galle, Jörg

Bivalent genes are frequently associated with developmental and lineage specification processes. Resolving their bivalency enables fast changes in their expression, which potentially can trigger cell fate decisions. Here, we provide a theoretical mod

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A89595
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Akademický článek

A Model-Based Analysis of Culture-Dependent Phenotypes of mESCs

Autor: Herberg, Maria, Kalkan, Tüzer, Glauche, Ingmar, Smith, Austin, Roeder, Ingo

Publikováno v: PLoS one, 2014, Volume 9, Issue 3, Article ID e92496, ISSN: 1932-6203

Mouse embryonic stem cells (mESCs) can be maintained in a proliferative and undifferentiated state over many passages (self-renewal) while retaining the potential to give rise to every cell type of the organism (pluripotency). Autocrine FGF4/Erk sign

Externí odkaz: http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-147356
http://www.qucosa.de/fileadmin/data/qucosa/documents/14735/10.1371_journal.pone.0092496.pdf

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