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Autor:
Hanlee P. Ji, Bjørn Tore Gjertsen, Stener Kvinnsland, Eric D. Lynch, Pål Møller, Ketil Heimdal, Elizabeth A. Ostermeyer, Patrick MacLeod, Karen Swisshelm, Mary Claire King, David Suchard, Herb Lubs, J. Fernando Arena, Ming K. Lee, Jamie L. Dann
Publikováno v:
The American Journal of Human Genetics. 61:1254-1260
SummaryPTEN, a protein tyrosine phosphatase with homology to tensin, is a tumor-suppressor gene on chromosome 10q23. Somatic mutations in PTEN occur in multiple tumors, most markedly glioblastomas. Germ-line mutations in PTEN are responsible for Cowd