Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2.

Autor: Lázaro-Gorines R; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Pérez P; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, 28029, Spain., Heras-Murillo I; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., Adán-Barrientos I; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., Albericio G; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Astorgano D; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Flores S; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Luczkowiak J; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain., Labiod N; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain., Harwood SL; Department of Molecular Biology and Genetics - Protein Science, Aarhus University, Aarhus, 80000, Denmark., Segura-Tudela A; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Rubio-Pérez L; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain.; Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, 28223, Spain., Nugraha Y; Protein Crystallography Unit, Structural Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Shang X; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA., Li Y; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Alfonso C; Centro de Investigaciones Biológicas Margarita Salas (CIB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28040, Spain., Adipietro KA; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA.; Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Abeyawardhane DL; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA.; Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA., Navarro R; Department of Antibody Engineering, Leadartis SL, Tres Cantos, Madrid, 28002, Spain., Compte M; Department of Antibody Engineering, Leadartis SL, Tres Cantos, Madrid, 28002, Spain., Yu W; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA., MacKerell AD Jr; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; Computer Aided Drug Design Center, Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD, 21201, USA.; Center for Biomolecular Therapeutics (CBT), University of Maryland School of Medicine, Baltimore, MD 21201, USA., Sanz L; Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, 28220, Spain., Weber DJ; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Blanco FJ; Centro de Investigaciones Biológicas Margarita Salas (CIB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28040, Spain., Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain., Pozharski E; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Godoy-Ruiz R; Institute for Bioscience and Biotechnology Research, University of Maryland, Rockville, MD, 20850, USA.; The Center for Biomolecular Therapeutics, Rockville, MD, 20850, USA., Muñoz IG; Protein Crystallography Unit, Structural Biology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain., Delgado R; Virology and HIV/AIDS Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; Department of Microbiology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Department of Medicine, Universidad Complutense de Madrid, Madrid, 28040, Spain., Sancho D; Immunobiology lab, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, 28029, Spain., García-Arriaza J; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, 28049, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Madrid, 28029, Spain., Álvarez-Vallina L; Cancer Immunotherapy Unit (UNICA), Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, 28041, Spain.; Immuno-Oncology and Immunotherapy Group, Instituto de Investigación Sanitaria 12 de Octubre (imas12), Madrid, 28041, Spain.; H12O-CNIO Cancer Immunotherapy Clinical Research Unit, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, 28029, Spain.; Chair for Immunology UFV/Merck, Universidad Francisco de Vitoria (UFV), Pozuelo de Alarcón, Madrid, 28223, Spain.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2023 Dec; Vol. 10 (34), pp. e2304818. Date of Electronic Publication: 2023 Oct 20.

Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.

Autor: Tundidor I; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain., Seijo-Vila M; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain., Blasco-Benito S; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain., Rubert-Hernández M; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain., Adámez S; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain., Andradas C; Brain Tumor Research Program, Telethon Kids Institute, Nedlands, WA, Australia.; Centre for Child Health Research, University of Western Australia, Nedlands, WA, Australia., Manzano S; Breast Cancer Group, Oncology Area, Biodonostia Health Research Institute, San Sebastián, Spain., Álvarez-López I; Breast Cancer Group, Oncology Area, Biodonostia Health Research Institute, San Sebastián, Spain.; Gipuzkoa Cancer Unit, OSI Donostialdea-Onkologikoa Foundation, San Sebastián, Spain., Sarasqueta C; Unit of Information and Healthcare Results, OSI Donostialdea, Biodonostia Health Research Institute, San Sebastián, Spain.; Methodological Support Unit, Biodonostia Health Research Institute, San Sebastián, Spain., Villa-Morales M; Centro de Biología Molecular Severo Ochoa (CBMSO) (CSIC-UAM), Madrid, Spain.; Department of Biology, Autonomous University of Madrid, Madrid, Spain., González-Lois C; Department of Pathology, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Ramírez-Medina E; Department of Obstetrics & Gynecology, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Almoguera B; Department of Obstetrics & Gynecology, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain., Sánchez-López AJ; Biobank Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain.; Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana (IDIPHISA), Madrid, Spain., Bindila L; Clinical Lipidomics Unit, Institute of Physiological Chemistry, University Medical Center, Mainz, Germany., Hamann S; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel, Germany., Arnold N; Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Kiel, Germany., Röcken C; Institute of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany., Heras-Murillo I; Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Sancho D; Immunobiology Laboratory, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Moreno-Bueno G; MD Anderson International Foundation; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM); Department of Biochemistry, Autonomous University of Madrid; Instituto de Investigación Hospital Universitario La Paz (IdiPaz); Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain., Caffarel MM; Breast Cancer Group, Oncology Area, Biodonostia Health Research Institute, San Sebastián, Spain.; Ikerbasque-Basque Foundation for Science, Bilbao, Spain., Guzmán M; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Instituto Ramón y Cajal de Investigación Sanitaria y Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain., Sánchez C; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain. macsanch@ucm.es.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain. macsanch@ucm.es., Pérez-Gómez E; Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain. eduperez@ucm.es.; Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain. eduperez@ucm.es.

Publikováno v: Nature communications [Nat Commun] 2023 May 30; Vol. 14 (1), pp. 3130. Date of Electronic Publication: 2023 May 30.

The Bacterial Mucosal Immunotherapy MV130 Protects Against SARS-CoV-2 Infection and Improves COVID-19 Vaccines Immunogenicity.

Autor: Del Fresno C; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; Department of Infectious Diseases and Immunity, Instituto de Investigación Biomédica del Hospital Universitario la Paz (IdiPAZ), Madrid, Spain., García-Arriaza J; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Martínez-Cano S; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.; R&D Department, Inmunotek S.L., Alcalá de Henares, Spain., Heras-Murillo I; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Jarit-Cabanillas A; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Amores-Iniesta J; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Brandi P; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Dunphy G; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Suay-Corredera C; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Pricolo MR; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Vicente N; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., López-Perrote A; Structural Biology Department, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Cabezudo S; Structural Biology Department, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., González-Corpas A; Structural Biology Department, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Llorca O; Structural Biology Department, Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Spain., Alegre-Cebollada J; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain., Garaigorta U; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Gastaminza P; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Esteban M; Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain., Sancho D; Department of Myocardial Pathophysiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.

Publikováno v: Frontiers in immunology [Front Immunol] 2021 Nov 18; Vol. 12, pp. 748103. Date of Electronic Publication: 2021 Nov 18 (Print Publication: 2021).

CD103 + cDC1 Dendritic Cell Vaccine Therapy for Osteosarcoma Lung Metastases.

Autor: Yang, Yuanzheng¹ (AUTHOR) yyang9@mdanderson.org, Zhou, Yifan^2,3 (AUTHOR) yfan_zhou@smu.edu.cn, Wang, Jian⁴ (AUTHOR) jianwang@mdanderson.org, Zhou, You¹ (AUTHOR) yzhou15@mdanderson.org, Watowich, Stephanie S.² (AUTHOR) swatowic@mdanderson.org, Kleinerman, Eugenie S.^1,5 (AUTHOR) ekleiner@mdanderson.org

Publikováno v: Cancers. Oct2024, Vol. 16 Issue 19, p3251. 19p.

Dual Adjuvant‐Loaded Peptide Antigen Self‐Assembly Potentiates Dendritic Cell‐Mediated Tumor Immunotherapy.

Autor: Kim, Jaehyun¹ (AUTHOR), Kang, Seyoung¹ (AUTHOR), Kim, Jisu¹ (AUTHOR), Yong, Seok‐Beom² (AUTHOR), Lahiji, Shayan Fakhraei^1,3 (AUTHOR), Kim, Yong‐Hee^1,3,4 (AUTHOR) yongheekim@hanyang.ac.kr

Publikováno v: Advanced Science. 9/25/2024, Vol. 11 Issue 36, p1-12. 12p.