A Complex Interplay of Anionic Phospholipid Binding Regulates 3'-Phosphoinositide-Dependent-Kinase-1 Homodimer Activation.

Autor: Heras-Martínez GL; Instituto Biofisika (CSIC, UPV/EHU), 48490, Leioa, Spain.; Cell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Instituto Biofisika (CSIC, UPV/EHU) & Research Centre for Experimental Marine Biology and Biotechnology (PiE), University of the Basque Country (UPV/EHU), Leioa, 48940, Spain., Calleja V; Protein Phosphorylation Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK., Bailly R; Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR 5248 CBMN) CNRS - Université de Bordeaux - Bordeaux INP All. Geoffroy Saint-Hilaire, 33600, Pessac, France., Dessolin J; Institute of Chemistry & Biology of Membranes & Nanoobjects (UMR 5248 CBMN) CNRS - Université de Bordeaux - Bordeaux INP All. Geoffroy Saint-Hilaire, 33600, Pessac, France., Larijani B; Cell Biophysics Laboratory, Ikerbasque Basque Foundation for Science, Instituto Biofisika (CSIC, UPV/EHU) & Research Centre for Experimental Marine Biology and Biotechnology (PiE), University of the Basque Country (UPV/EHU), Leioa, 48940, Spain. banafshe.larijani@ikerbasque.org.; Centre for Therapeutic Innovation (CTI-Bath); Cell Biophysics Laboratory Department of Pharmacy & Pharmacology University, Bath, Claverton Down, Bath, BA2 7AY, United Kingdom. banafshe.larijani@ikerbasque.org., Requejo-Isidro J; Instituto Biofisika (CSIC, UPV/EHU), 48490, Leioa, Spain. jose.requejo@csic.es.; Centro Nacional de Biotecnología (CSIC), Darwin, 3, E28049, Madrid, Spain. jose.requejo@csic.es.; Unidad de Nanobiotecnología, CNB-CSIC-IMDEA Nanociencia Associated Unit, 28049, Madrid, Spain. jose.requejo@csic.es.

Publikováno v: Scientific reports [Sci Rep] 2019 Oct 10; Vol. 9 (1), pp. 14527. Date of Electronic Publication: 2019 Oct 10.