Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Her Sheng Lin"'
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
Current cytotoxic chemotherapy produces clinical benefit in patients with breast cancer but the survival impact is modest. To explore novel cytotoxic agents for the treatment of advanced disease, we have characterized a new and pharmacokinetically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a1cce64a84b11cad22e18b8aee0b62
https://doi.org/10.1158/1535-7163.c.6536740.v1
https://doi.org/10.1158/1535-7163.c.6536740.v1
Autor:
Johnson Y.N. Lau, Her-Sheng Lin, Chia-Wei Liu, Pei-Yi Tsai, Gillian M.G. Lau, Kuo-Jang Kao, Shih-Hsien Chuang, Jiann-Jyh Huang, Jia-Ming Chang, Ying-Shuan Lee, Chia-Chi Chang, Lynn Y.L. Huang
PDF - 126K, Includes the methods for preparation of TAI-95, drug-drug synergy experiments, and preliminary subacute toxicology, Table S1: Combination index of TAI-95 with anticancer agents, and supplementary figure legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03cd2d4da138a03a29f6a3af653804d2
https://doi.org/10.1158/1535-7163.22501294
https://doi.org/10.1158/1535-7163.22501294
Autor:
Shu Fu Lin, Li-Wei Teng, Ya-Chi Huang, Shyh-Fong Chen, Guan-Ru Huang, Chih-Lin Chang, Pi-Chen Hsu, Min-Sian Huang, Yu-Sheng Gao, Ya-Wen Chan, Jiann-Jyh Huang, Sheng-Chuan Yang, Bo-Han Jian, Yann-Yu Lu, Yu-Fen Chen, Tzu-Hao Lo, Shih-Hsien Chuang, Wen-Yun Hsueh, Po-Hsun Huang, Hsin-Yi Huang, Lien-Hsiang Chang, Win-Yin Wei, Ying-Chou Chen, Her-Sheng Lin, Shan-Yen Chou, Ta-Tung Yuan, Yu-Ting Chao, Ying-Shuan E. Lee, Yi-Feng Kao, Yu-Hsiang Lin, Jo-Chu Lin, Hung-Huang Liu, Shao-Yun Wang, Chin-Hung Lai, Shin-Yi Huang
Publikováno v:
Journal of Medicinal Chemistry. 64:1435-1453
In this paper, we present a copper(I)-catalyzed nitrile-addition/N-arylation ring-closure cascade for the synthesis of 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones from 2-(2-bromophenyl)-N-(2-cyanophenyl)acetamides. Using CuBr and t-BuONa in dimethyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fcb962b8cc2da85f8b630161defbab0
https://doi.org/10.1021/acs.jmedchem.0c00727
https://doi.org/10.1021/acs.jmedchem.0c00727
Autor:
Wen-Yun, Hsueh, Ying-Shuan E, Lee, Min-Sian, Huang, Chin-Hung, Lai, Yu-Sheng, Gao, Jo-Chu, Lin, Yu-Fen, Chen, Chih-Lin, Chang, Shan-Yen, Chou, Shyh-Fong, Chen, Yann-Yu, Lu, Lien-Hsiang, Chang, Shu Fu, Lin, Yu-Hsiang, Lin, Pi-Chen, Hsu, Win-Yin, Wei, Ya-Chi, Huang, Yi-Feng, Kao, Li-Wei, Teng, Hung-Huang, Liu, Ying-Chou, Chen, Ta-Tung, Yuan, Ya-Wen, Chan, Po-Hsun, Huang, Yu-Ting, Chao, Shin-Yi, Huang, Bo-Han, Jian, Hsin-Yi, Huang, Sheng-Chuan, Yang, Tzu-Hao, Lo, Guan-Ru, Huang, Shao-Yun, Wang, Her-Sheng, Lin, Shih-Hsien, Chuang, Jiann-Jyh, Huang
Publikováno v:
Journal of medicinal chemistry. 64(3)
In this paper, we present a copper(I)-catalyzed nitrile-addition/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f6c10c7f95ae0e1e8f3936e79865440
https://pubmed.ncbi.nlm.nih.gov/33492141
https://pubmed.ncbi.nlm.nih.gov/33492141
Autor:
Chia-chi Chang, Jiann-Jyh Huang, Ying-Shuan Lee, Gillian M.G. Lau, Johnson Y.N. Lau, Her-Sheng Lin, Lynn Y L Huang, Robert G. Gish, Kuo-Jang Kao, Jia-Ming Chang, Shih-Hsien Chuang, Chia-Wei Liu, Pei-Yi Tsai
Publikováno v:
Cancer Chemotherapy and Pharmacology. 74:511-520
Highly expressed in cancer protein 1 (Hec1) is an oncogene and a promising molecular target for novel anticancer drugs. The purpose of this study was to evaluate the potential of a Hec1 inhibitor, TAI-95, as a treatment for primary liver cancer.In vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc93731eed61d9178891ac831dc33e6
https://doi.org/10.1007/s00280-014-2540-7
https://doi.org/10.1007/s00280-014-2540-7
Autor:
Sheng-Chuan Yang, Ying-Shuan E. Lee, Chia-Wei Liu, Johnson Y.N. Lau, Shih-Hsien Chuang, Jun-Yu Lai, Her-Sheng Lin, Jia-Ming Chang, Ju-Ying Yang, Pei-Shiou Jian, Chun-Liang Lai, Yu-Hsiang Lin, Chia-chi Chang, Lynn Y L Huang, King Lam, Jiann-Jyh Huang
Publikováno v:
Journal of Medicinal Chemistry. 57:4098-4110
A series of 4-aryl-N-arylcarbonyl-2-aminothiazoles of scaffold 4 was designed and synthesized as Hec1/Nek2 inhibitors. Structural optimization of 4 led to compound 32 bearing C-4' 4-methoxyphenoxy and 4-(o-fluoropyridyl)carbonyl groups that showed lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d504084ddc0ce8f2f3faf532d64389ea
https://doi.org/10.1021/jm401990s
https://doi.org/10.1021/jm401990s
Autor:
Yu-Wen Tseng, Yann-Yu Lu, Mann-Yan Kuo, Chu-Bin Liao, Shian-Yi Chiou, Chia Wei Liu, Ying-Shuan Lee, Her Sheng Lin, Shao-Zheng Pen, Win Yin Wei
Publikováno v:
Cancer Research. 77:134-134
The Hedgehog (Hh) signaling pathway is a critical regulator of embryonic patterning, and aberrant Hh pathway activation has been implicated in a diverse spectrum of cancers. Therefore, components of the Shh pathway (such as Shh, SMO, and GLI1/2) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fb69950bd82bcd2bf8c8a8a6745e183
https://doi.org/10.1158/1538-7445.am2017-134
https://doi.org/10.1158/1538-7445.am2017-134
Autor:
Chia-Wei Liu, Jia-Ming Chang, Jiann-Jyh Huang, Lynn Y L Huang, Shih-Hsien Chuang, Chia-chi Chang, Johnson Y.N. Lau, Pei-Yi Tsai, Kuo-Jang Kao, Her-Sheng Lin, Ying-Shuan Lee, Gillian M.G. Lau
Publikováno v:
Molecular cancer therapeutics. 13(6)
Current cytotoxic chemotherapy produces clinical benefit in patients with breast cancer but the survival impact is modest. To explore novel cytotoxic agents for the treatment of advanced disease, we have characterized a new and pharmacokinetically im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b158f2339e737f64dd68bcab189d5e69
https://pubmed.ncbi.nlm.nih.gov/24694948
https://pubmed.ncbi.nlm.nih.gov/24694948
Autor:
Jiann-Jyh Huang, Jia-Ming Chang, Her-Sheng Lin, Yung-Jen Tsai, Pei-Yi Tsai, Ying-Shuan Lee, Chia-Wei Liu, Chia-chi Chang, Kuo-Jang Kao, Shih-Hsien Chuang, Lynn Y L Huang, Johnson Y.N. Lau
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Background Hec1 (NDC80) is an integral part of the kinetochore and is overexpressed in a variety of human cancers, making it an attractive molecular target for the design of novel anticancer therapeutics. A highly potent first-in-class compound targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed010dae9a4854ed80a5ba1a6f98bc12
https://doi.org/10.1186/1756-9966-33-6
https://doi.org/10.1186/1756-9966-33-6
Publikováno v:
Urological Research. 29:89-93
Nephrocalcin (NC) is a potent crystal growth inhibitor of calcium oxalate monohydrate. However, the sequence is undefined owing to its multiple glycosylations. Although there have been many biochemical studies of the binding capacity of calcium, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2189bd9b75186e1c2cab896862654e8
https://doi.org/10.1007/s002400000164
https://doi.org/10.1007/s002400000164