Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Hequan Yao"'
Publikováno v:
Advanced Science, Vol 11, Iss 24, Pp n/a-n/a (2024)
Abstract Palladium‐catalyzed Suzuki–Miyaura (SM) coupling is a valuable method for forming C─C bonds, including those between aryl moieties. However, achieving atroposelective synthesis of axially chiral styrenes via SM coupling remains challen
Externí odkaz:
https://doaj.org/article/29670d2b5af243dc85a0a6efa9e662c8
Autor:
Wenying Shan, Lvqi Chen, Hao Xu, Qinghao Zhong, Yinqiu Xu, Hequan Yao, Kejiang Lin, Xuanyi Li
Publikováno v:
Frontiers in Chemistry, Vol 11 (2023)
Identifying compound–protein interaction plays a vital role in drug discovery. Artificial intelligence (AI), especially machine learning (ML) and deep learning (DL) algorithms, are playing increasingly important roles in compound-protein interactio
Externí odkaz:
https://doaj.org/article/a2295691c26a4e3eb7105b20938e72d9
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
The Alder–ene type reaction is a synthetically useful, redox-neutral method to rearrange carbon–carbon bonds, but has only been demonstrated intramolecularly. Here the authors present a method to perform the Alder–ene type reaction intermolecul
Externí odkaz:
https://doaj.org/article/1c1cf55e2fd54ec5bd5abcb7fd7bbe80
Publikováno v:
Journal of Cheminformatics, Vol 12, Iss 1, Pp 1-13 (2020)
Abstract With the rise of artificial intelligence (AI) in drug discovery, de novo molecular generation provides new ways to explore chemical space. However, because de novo molecular generation methods rely on abundant known molecules, generated mole
Externí odkaz:
https://doaj.org/article/7411590ab4b74d18be4bb4aeb7fd19b8
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Tandem Heck/carbonylation reaction gives access to ubiquitous carbonyl molecules, however the asymmetric version is rarely studied. Here, the authors synthesize chiral bicyclo[3.2.1]octanes with a palladium-catalyzed asymmetric tandem Heck/carbonylat
Externí odkaz:
https://doaj.org/article/8db740ae56e844d88c1f4318a0aea403
Autor:
Xinnan Li, Yilin Jia, Junda Li, Pengfei Zhang, Tiantian Li, Li Lu, Hequan Yao, Jie Liu, Zheying Zhu, Jinyi Xu
Publikováno v:
Molecules, Vol 27, Iss 10, p 3090 (2022)
Alzheimer’s disease (AD) is a neurodegenerative disease that causes memory and cognitive decline as well as behavioral problems. It is a progressive and well recognized complex disease; therefore, it is very urgent to develop novel and effective an
Externí odkaz:
https://doaj.org/article/d0e543af492f49a1876b80a1170652ad
Publikováno v:
Molecules, Vol 24, Iss 10, p 1940 (2019)
The programmed cell death ligand protein 1 (PD-L1) is a member of the B7 protein family and consists of 290 amino acid residues. The blockade of the PD-1/PD-L1 immune checkpoint pathway is effective in tumor treatment. Results: Two pharmacophore mode
Externí odkaz:
https://doaj.org/article/2dd2cc306a804dd5a9446fa9eb306bb5
Publikováno v:
Molecules, Vol 16, Iss 6, Pp 4681-4694 (2011)
Natural products with interesting biological properties and structural diversity have often served as valuable lead drug candidates for the treatment of various human diseases. Largazole, isolated from the marine cyanobacterium Symploca sp. has exhib
Externí odkaz:
https://doaj.org/article/c577348db8174146bc14c310e920dfbc
Autor:
Xinnan Li, Xiaotong Ze, Shengnan Zhou, Zhaoxin Hu, Chen He, Yilin Jia, Lihua Liu, Tao Wang, Junda Li, Shengtao Xu, Dong-Hua Yang, Zhe-Sheng Chen, Hequan Yao, Jinyi Xu, Hong Yao
Publikováno v:
Journal of Medicinal Chemistry. 66:5118-5153
Autor:
Xiaolian Ning, Qidan Li, Jin Zi, Zhanlong Mei, Jie Liu, Yuxing Zhang, Mao Bi, Yan Ren, Xingang Liu, Chao Lv, Hequan Yao, Jianguo Sun, Feng Rao, Shuwei Li, Siqi Liu
Publikováno v:
Analytical Chemistry. 95:5788-5795