Cyclizations and fragmentations in the alkylation of 6‐chloro‐5‐hydroxy‐4‐aminopyrimidines with aminoalkyl chlorides.

Autor: Picazo, Edwige M. H.¹ (AUTHOR), Heptinstall, Amy B.¹ (AUTHOR), Wilson, David M.² (AUTHOR), Cano, Céline¹ (AUTHOR), Golding, Bernard T.³ (AUTHOR), Waring, Michael J.¹ (AUTHOR) mike.waring@ncl.ac.uk

Publikováno v: Journal of Heterocyclic Chemistry. Apr2021, Vol. 58 Issue 4, p947-951. 5p.

Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool

Autor: Miller, Duncan C., Reuillon, Tristan, Molyneux, Lauren, Blackburn, Timothy J., Cook, Simon, Edwards, Noel, Endicott, Jane A., Golding, Bernard T., Griffin, Roger J., Hardcastle, Ian R., Heptinstall, Amy B., Lochhead, Pamela, Martin, Mathew P., Martin, Nick, Myers, Stephanie M., Newell, David R., Noble, Richard, Rigoreau, Laurent J.M., Thomas, Huw, Tucker, Julie Ann, Wang, Lan-Zhen, Waring, Michael J., Wong, Ai-Ching, Wedge, Stephen, Noble, Martin, Cano, Celine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::643876374a98b92971005d5d769a4162
https://eprints.whiterose.ac.uk/185363/3/acs.jmedchem.1c01756.pdf

An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

Autor: Al-Khawaldeh, Islam, Alyassiri, Mohammed, Aldred, Greg, Basmadjian, Christine, Bordoni, Cinzia, Harnor, Suzannah J., Heptinstall, Amy B., Hobson, Stephen, Jennings, Claire, Khalifa, Shaimaa, Lebraud, Honorine, Martin, Mathew P., Miller, Duncan C, Shrives, Harry, De Souza, Joao, Stewart, Hannah, Temple, Max J, Thomas, Huw, Totobenazara, Jane, Tucker, Julie Ann, Tudhope, Susan, Wang, Lan-Zhen, Bronowska, Agnieszka, Cano, Celine, Endicott, Jane A., Golding, Bernard, Hardcastle, Ian R., Hickson, Ian, Wedge, Stephen, Willmore, Elaine, Noble, Martin E. M., Waring, Michael J.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::0d0425a07b4fd1c06ab32621f25fa4ab
https://eprints.whiterose.ac.uk/175696/1/Revised_Manuscript_2_.docx

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Temporal Dynamics of Cardiovascular Risk in Patients with Chronic Obstructive Pulmonary Disease During Stable Disease and Exacerbations: Review of the Mechanisms and Implications.

Autor: Simons SO; Department of Respiratory Medicine, NUTRIM Institute for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.; Department of Respiratory Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands., Heptinstall AB; Maverex Ltd, Newcastle Upon Tyne, UK., Marjenberg Z; Maverex Ltd, Newcastle Upon Tyne, UK., Marshall J; BioPharmaceuticals Medical, Respiratory and Immunology, AstraZeneca, Cambridge, UK., Mullerova H; BioPharmaceuticals Medical, Respiratory and Immunology, AstraZeneca, Cambridge, UK., Rogliani P; Department of Experimental Medicine, Unit of Respiratory Medicine, University of Rome 'Tor Vergata', Rome, Italy., Nordon C; BioPharmaceuticals Medical, Respiratory and Immunology, AstraZeneca, Cambridge, UK., Hawkins NM; Cardiology, University of British Columbia, Vancouver, Canada.

Publikováno v: International journal of chronic obstructive pulmonary disease [Int J Chron Obstruct Pulmon Dis] 2024 Oct 10; Vol. 19, pp. 2259-2271. Date of Electronic Publication: 2024 Oct 10 (Print Publication: 2024).