Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

Autor: Medina-Gomez C; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Kemp JP; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Trajanoska K; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Luan J; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Chesi A; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark; Steno Diabetes Center, Copenhagen 2820, Denmark., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Centre, 2333 ZA Leiden, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Centre, 2333 ZA Leiden, the Netherlands., Ham A; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Hartwig FP; Postgraduate Program in Epidemiology, Federal University of Pelotas, 96020220 Pelotas, Brazil., Evans DS; California Pacific Medical Center Research Institute, San Francisco, CA 94107, USA., Joro R; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio 70211, Finland., Nedeljkovic I; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Zheng HF; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montreal, QC H3A 1A2, Canada; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Westlake University, Hangzhou, 100080 Zhejiang, China; Institute of Aging Research and the Affiliated Hospital, School of Medicine, Hangzhou Normal University, Hangzhou, 311121 Zhejiang, China., Zhu K; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia., Atalay M; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio 70211, Finland., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02131, USA., Nethander M; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, 41390 Gothenburg, Sweden., Broer L; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Porleifsson G; deCODE Genetics/Amgen, Reykjavik 101, Iceland., Mullin BH; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia., Handelman SK; Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA; Data Tecnica International, Glen Echo, MD 20812, USA., Jessen LE; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark., Heppe DHM; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Richards JB; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montreal, QC H3A 1A2, Canada; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada., Wang C; School of Women's and Infants' Health, University of Western Australia, Crawley, WA 6009, Australia., Chawes B; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark., Schraut KE; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH16 4UX, Scotland; Centre for Cardiovascular Sciences, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland., Amin N; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Wareham N; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Karasik D; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA 02131, USA; Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 1311502, Israel., Van der Velde N; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Internal Medicine, Section of Geriatrics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands., Ikram MA; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Zemel BS; Division of GI, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Zhou Y; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02131, USA., Carlsson CJ; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark., Liu Y; Wake Forest School of Medicine, Winston-Salem, NC 27101, USA., McGuigan FE; Lund University, Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, 20502 Malmö, Sweden., Boer CG; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark., Ralston SH; Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland., Robbins JA; Department of Medicine, University of California, Davis, Sacramento, CA 95817, USA., Walsh JP; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia., Zillikens MC; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Langenberg C; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Centre, 2333 ZA Leiden, the Netherlands., Williams FMK; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA., Akesson K; Lund University, Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, 20502 Malmö, Sweden; Skåne University Hospital, Department of Orthopedics, 21428 Malmö, Sweden., Jackson RD; Division of Endocrinology, Diabetes, and Metabolism, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA., Sigurdsson G; Department of Endocrinology and Metabolism, Landspitali, The National University Hospital of Iceland, Reykjavik 101, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland., den Heijer M; Department of Clinical Epidemiology, Leiden University Medical Centre, 2333 ZA Leiden, the Netherlands; Department of Clinical Epidemiology and Department of Internal Medicine, VU Medical Center, 1081 HV Amsterdam, the Netherlands., van der Eerden BCJ; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., van de Peppel J; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Spector TD; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., Pennell C; School of Women's and Infants' Health, University of Western Australia, Crawley, WA 6009, Australia., Horta BL; Postgraduate Program in Epidemiology, Federal University of Pelotas, 96020220 Pelotas, Brazil., Felix JF; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Zhao JH; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Wilson SG; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, WA 6009, Australia; Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK., de Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Centre, 2333 ZA Leiden, the Netherlands., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen 2820, Denmark., Styrkársdóttir U; deCODE Genetics/Amgen, Reykjavik 101, Iceland., Jaddoe VW; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Pediatrics, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Orwoll E; Department of Public Health & Preventive Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Lakka TA; Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio 70211, Finland; Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio 70210, Finland., Scott R; MRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK., Grant SFA; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Lorentzon M; Geriatric Medicine, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, 40530 Gothenburg, Sweden., van Duijn CM; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Wilson JF; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH16 4UX, Scotland; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, Scotland., Stefansson K; deCODE Genetics/Amgen, Reykjavik 101, Iceland; Department of Endocrinology and Metabolism, Landspitali, The National University Hospital of Iceland, Reykjavik 101, Iceland., Psaty BM; Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA 98101, USA., Kiel DP; Hebrew SeniorLife, Institute for Aging Research, Roslindale, MA 02131, USA; Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Boston, MA 02115, USA., Ohlsson C; Center for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, 41345 Gothenburg, Sweden., Ntzani E; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece., van Wijnen AJ; Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN 55905, USA., Forgetta V; Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montreal, QC H3A 1A2, Canada; Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montreal, QC H3T 1E2, Canada., Ghanbari M; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran., Logan JG; Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London W12 0NN, UK., Williams GR; Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London W12 0NN, UK., Bassett JHD; Molecular Endocrinology Laboratory, Department of Medicine, Imperial College London, London W12 0NN, UK., Croucher PI; Garvan Institute of Medical Research, Sydney, NSW 2010, Australia., Evangelou E; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK., Uitterlinden AG; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands., Ackert-Bicknell CL; Center for Musculoskeletal Research, University of Rochester, Rochester, NY 14642,USA., Tobias JH; School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, UK., Evans DM; University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, QLD 4102, Australia; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK., Rivadeneira F; Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, 3000 CA Rotterdam, the Netherlands; Department of Epidemiology, Erasmus MC, 3000 CA Rotterdam, the Netherlands. Electronic address: f.rivadeneira@erasmusmc.nl.

Publikováno v: American journal of human genetics [Am J Hum Genet] 2018 Jan 04; Vol. 102 (1), pp. 88-102.

Bone Mass and Strength in School-Age Children Exhibit Sexual Dimorphism Related to Differences in Lean Mass: The Generation R Study.

Autor: Medina-Gomez C; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Heppe DHM; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Yin JL; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Trajanoska K; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Uitterlinden AG; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Beck TJ; Beck Radiological Innovations Inc., Baltimore, MD, USA.; Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Jaddoe VWV; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Pediatrics, Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., Rivadeneira F; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 2016 May; Vol. 31 (5), pp. 1099-106. Date of Electronic Publication: 2016 Jan 08.