Empiric vs Preemptive Antifungal Strategy in High-Risk Neutropenic Patients on Fluconazole Prophylaxis: A Randomized Trial of the European Organization for Research and Treatment of Cancer

Autor: Maertens, Johan, Lodewyck, Tom, Donnelly, J Peter, Chantepie, Sylvain, Robin, Christine, Blijlevens, Nicole, Turlure, Pascal, Selleslag, Dominik, Baron, Frederic, Aoun, Mickael, Heinz, Werner J, Bertz, Hartmut, Racil, Zdenek, Vandercam, Bernard, Drgona, Lubos, Coiteux, Valerie, Llorente, Cristina Castilla, Schaefer-Prokop, Cornelia, Paesmans, Marianne, Ameye, Lieveke, Meert, Liv, Cheung, Kin Jip, Hepler, Deborah A, Loeffler, Juergen, Barnes, Rosemary, Marchetti, Oscar, Verweij, Paul, Lamoth, Frederic, Bochud, Pierre-Yves, Schwarzinger, Michael, Cordonnier, Catherine

Publikováno v: Clinical Infectious Diseases, 76, 674-682
Clinical Infectious Diseases, 76, 4, pp. 674-682

Background Empiric antifungal therapy is considered the standard of care for high-risk neutropenic patients with persistent fever. The impact of a preemptive, diagnostic-driven approach based on galactomannan screening and chest computed tomography s

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https://doi.org/10.1093/cid/ciac623

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Empiric vs Preemptive Antifungal Strategy in High-Risk Neutropenic Patients on Fluconazole Prophylaxis: A Randomized Trial of the European Organization for Research and Treatment of Cancer.

Autor: Maertens J; Department of Hematology, University Hospitals Leuven, Leuven, Belgium., Lodewyck T; Department of Hematology, Algemeen Ziekenhuis St Jan, Brugge, Belgium., Donnelly JP; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Chantepie S; Department of Hematology, Caen University Hospital, Caen, France., Robin C; Department of Hematology, Centre Hospitalier Universitaire Henri Mondor, Créteil, France., Blijlevens N; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Turlure P; Department of Hematology, Centre Hospitalier Universitaire Limoges, Limoges, France., Selleslag D; Department of Hematology, Algemeen Ziekenhuis St Jan, Brugge, Belgium., Baron F; Department of Hematology, University of Liège and University Hospital of Liège, Liège, Belgium., Aoun M; Department of Internal Medicine, Institut Jules Bordet, Brussels, Belgium., Heinz WJ; Department of Hematology/Oncology, Caritas Hospital, Bad Mergentheim, Germany., Bertz H; Department of Hematology/Oncology, Faculty of Medicine and Medical Centre, University of Freiburg, Freiburg, Germany., Ráčil Z; Department of Hematology, Masaryk University Brno and Institute of Hematology and Blood Transfusion, Prague, Czech Republic., Vandercam B; Department of Internal Medicine/Infectious Diseases, Cliniques Universitaires St. Luc, Brussels, Belgium., Drgona L; Department of Oncohematology, Comenius University and National Cancer Institute, Bratislava, Slovakia., Coiteux V; Service des maladies du sang, Centre Hospitalier Régional Universitaire Lille, Lille, France., Llorente CC; Department of Hematology, Gustave Roussy Cancer Campus, Villejuif, France., Schaefer-Prokop C; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Paesmans M; Department of Internal Medicine, Institut Jules Bordet, Brussels, Belgium., Ameye L; Department of Internal Medicine, Institut Jules Bordet, Brussels, Belgium., Meert L; European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium., Cheung KJ; European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium., Hepler DA; Merck & Co, Inc, Kenilworth, New Jersey, USA., Loeffler J; Department of Internal Medicine II, Universitaetsklinikum, Würzburg, Germany., Barnes R; Department of Infection, Immunity and Biochemistry, Cardiff University, Cardiff, United Kingdom., Marchetti O; Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.; Department of Infectious Diseases, Ensemble Hospitalier de la Côte, Morges, Switzerland., Verweij P; Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands., Lamoth F; Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland., Bochud PY; Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland., Schwarzinger M; Translational Health Economics Network, Bordeaux University Hospital, Bordeaux, France., Cordonnier C; Department of Hematology, Centre Hospitalier Universitaire Henri Mondor, Créteil, France.

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Feb 18; Vol. 76 (4), pp. 674-682.