Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Hepei Chen"'
Autor:
John J. Kremer, C. Michael Foley, William A. Meier, Hepei Chen, Mark A. Osinski, Andrew J. Bills, Nathanael J. Hanke
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:27-37
Introduction Nonclinical safety studies are increasingly incorporating cardiac safety endpoints to discover potential cardiovascular liabilities. This trend for more thorough cardiovascular nonclinical safety evaluation is prudent given the high attr
Autor:
John J. Kremer, Hepei Chen, Andrew J. Bills, C. Michael Foley, Gary T. Wittwer, Andrea Z. Mitchell, Mark A. Osinski
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:62-73
Introduction Dogs are commonly used in cardiovascular drug safety assessment, and implanted telemetry models include subcutaneous or epicardial electrocardiogram (ECG) electrode placements. The purpose of this study was to determine the sensitivity o
Autor:
Molly B. Conroy, Eswar Krishnan, Tamara B. Harris, C. Kent Kwoh, Michael C. Nevitt, Anne B. Newman, Bret H. Goodpaster, Robert M. Boudreau, Hepei Chen, Laura D Carbone
Publikováno v:
Arthritis Care & Research. 64:15-21
Osteoarthritis (OA) of the knee is a major cause of disability among the elderly (1–3), and its prevalence is projected to grow substantially with the aging of the U.S. population (2,4). Despite the high prevalence of this condition and the high pe
Autor:
Yong Xu, Marie McKeon, Ajit K. Thakur, Timothy E. Lawlor, H. Murli, Daniel J. Roberts, Leon F. Stankowski, Hepei Chen
Publikováno v:
Environmental and Molecular Mutagenesis. 52:738-747
As part of the Stage III Pig-a multilaboratory validation trial, we examined the induction of CD59-negative reticulocytes and total red blood cells (RETCD59− and RBCCD59−, respectively) in male Sprague Dawley® rats treated with 4-nitroquinoline-
Autor:
Kent Kwoh, Michael C. Nevitt, T.B. Harris, Suzanne Satterfield, G. Neumann, Lori B. Chibnik, Jeffrey Duryea, David J. Hunter, Hepei Chen
Publikováno v:
Osteoarthritis and Cartilage. 17(6):761-765
Summary Objective To establish the performance of location specific computer measures of radiographic joint space width (JSW) compared to measurements of minimum joint space width (mJSW) for the assessment of medial compartment knee osteoarthritis (O
Autor:
Lenore J. Launer, Hepei Chen, Helen Petrovitch, Kamal Masaki, Monique M.B. Breteler, Alan T. Remaley, Frank Jan de Jong, Lon R. White
Publikováno v:
Neurobiology of Aging, 30(4), 600-606. Elsevier Inc.
Thyroid dysfunction is associated with cognitive impairment and dementia, including Alzheimer's disease (AD). It remains unclear whether thyroid dysfunction results from, or contributes to, Alzheimer pathology. We determined whether thyroid function
Autor:
Stephen B. Kritchevsky, Kathy Ryder, Anne B. Newman, Ann V. Schwartz, Hepei Chen, Tamara B. Harris, Kushang V. Patel, Nathalie de Rekeneire, Todd M. Manini, Bret H. Goodpaster, Eleanor M. Simonsick, Marjolein Visser, Seok Won-Park, Elsa S. Strotmeyer
Publikováno v:
Journal of the American Geriatrics Society. 55:451-457
OBJECTIVES: To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults. DESIGN: Prospective cohort study. SETTING: University clinic
Autor:
Charles Peterfy, Hepei Chen, Tamara B. Harris, Jeff Duryea, David T. Felson, Michael C. Nevitt, Thasia G. Woodworth, Kent Kwoh, Ali Guermazi
Publikováno v:
Arthritis and rheumatism. 56(5)
Objective The ability of nonfluoroscopically guided radiography of the knee to assess joint space loss is an important issue in studies of progression and treatment of knee osteoarthritis (OA), given the practical limitations of protocols involving f
Autor:
Todd M, Manini, Marjolein, Visser, Seok, Won-Park, Kushang V, Patel, Elsa S, Strotmeyer, Hepei, Chen, Bret, Goodpaster, Nathalie, De Rekeneire, Anne B, Newman, Eleanor M, Simonsick, Stephen B, Kritchevsky, Kathy, Ryder, Ann V, Schwartz, Tamara B, Harris
Publikováno v:
Journal of the American Geriatrics Society. 55(3)
To identify levels of knee extensor strength that are associated with high and low risk of incident severe mobility limitation (SML) in initially well-functioning older adults.Prospective cohort study.University clinic center.One thousand three hundr
Autor:
Helen Petrovitch, Hepei Chen, Lon R. White, Kamal Masaki, Webster Ross, Lenore J. Launer, Frank Jan de Jong
Publikováno v:
Alzheimer's & Dementia. 2