Výsledky vyhledávání - "Hepatocytes/pathology"

Necroptosis microenvironment directs lineage commitment in liver cancer

Publikováno v: Nature
Nature, Nature Publishing Group, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩
Nature, 2018, 562 (7725), pp.69-75. ⟨10.1038/s41586-018-0519-y⟩

Comment in :- Neighbourhood deaths cause a switch in cancer subtype. [Nature. 2018]- Neighbourly deaths dictate fate. [Nat Rev Cancer. 2018]- Bad neighborhoods: apoptotic and necroptotic microenvironments determine liver cancer subtypes. [Hepatobilia

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The functional role of sodium taurocholate cotransporting polypeptide NTCP in the life cycle of hepatitis B, C and D viruses

Autor: Eloi R. Verrier, Carla Eller, Thomas F. Baumert, Catherine Schuster, Laura Heydmann, Che C. Colpitts

Publikováno v: Cellular and Molecular Life Sciences Cmls
Cellular and Molecular Life Sciences Cmls, 2018, 75 (21), pp.3895-3905. ⟨10.1007/s00018-018-2892-y⟩
Cell Mol Life Sci
Cellular and Molecular Life Sciences

Chronic hepatitis B, C and D virus (HBV, HCV and HDV) infections are a major cause of liver disease and cancer worldwide. Despite employing distinct replication strategies, the three viruses are exclusively hepatotropic, and therefore depend on hepat

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https://hal.archives-ouvertes.fr/hal-02374180/document

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Virology and cell biology of the hepatitis C virus life cycle – An update

Autor: Jean Dubuisson, François-Loïc Cosset

Publikováno v: Journal of Hepatology
Journal of Hepatology, 2014, Journal of Hepatology Update: Hepatitis C, 61 (1 Suppl), pp.S3-S13. ⟨10.1016/j.jhep.2014.06.031⟩
Journal of Hepatology, Elsevier, 2014, Journal of Hepatology Update: Hepatitis C, 61 (1 Suppl), pp.S3-S13. ⟨10.1016/j.jhep.2014.06.031⟩

Affiliations ECOFECT; International audience; Hepatitis C virus (HCV) is an important human pathogen that causes hepatitis, liver cirrhosis and hepatocellular carcinoma. It imposes a serious problem to public health in the world as the population of

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Lack ofin vivo blockade of Fas- and TNFR1-mediated hepatocyte apoptosis by the hepatitis C virus

Autor: Laurent Spahr, Laura Rubbia-Brandt, Rafael Quadri, Karim Abid, Patrizia Gindre, Sophia Taylor, Francesco Negro

Publikováno v: The Journal of pathology, vol. 197, no. 5, pp. 617-623

In vitro data have shown that the hepatitis C virus (HCV) core protein binds to protein members of the tumour necrosis factor receptor (TNFR) superfamily. Since this interaction could be relevant to HCV persistence and oncogenesis, this study assesse

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https://doi.org/10.1002/path.1148

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Chromosomal abnormalities in liver cell dysplasia detected by comparative genomic hybridisation

Autor: Pierre Tiollais, Pascal Pineau, Alain Bernheim, Benoit Terris, Mounira Meddeb, Agnès Marchio, A. Duverger, Anne Dejean

Publikováno v: Molecular Pathology
Molecular Pathology, BMJ Publishing Group, 2001, 54 (4), pp.270-274. ⟨10.1136/mp.54.4.270⟩
Molecular Pathology, 2001, 54 (4), pp.270-274. ⟨10.1136/mp.54.4.270⟩

Background/Aim—The pathogenetic relation between liver cell dysplasia and hepatocellular carcinoma (HCC) is poorly understood. The aim of this study was to determine whether there is a genetic link between liver cell dysplasia and HCC that could su

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https://doi.org/10.1136/mp.54.4.270

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HIV-1 Tropism and Liver Fibrosis in HIV–HCV Co-Infected Patients

Autor: Florence Abravanel, Stéphanie Raymond, Elodie Pambrun, Maria Winnock, Philippe Bonnard, Philippe Sogni, Pascale Trimoulet, François Dabis, Dominique Salmon-Ceron, Jacques Izopet, ANRS CO13 HEPAVIH Study Group

Publikováno v: PLoS ONE
PLoS ONE, 2012, 7 (11), pp.e50289. ⟨10.1371/journal.pone.0050289⟩
PLoS ONE, Vol 7, Iss 11, p e50289 (2012)

Background and aimsHepatic stellate cells, the major producers of extracellular matrix in the liver, and hepatocytes bear CXCR4 and CCR5, the two main co-receptors for entry of the human immunodeficiency virus (HIV). In vitro studies suggest that HIV

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https://ut3-toulouseinp.hal.science/hal-03575489

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IL12-Mediated Liver Inflammation Reduces the Formation of AAV Transcriptionally Active Forms but Has No Effect over Preexisting AAV Transgene Expression

Autor: Lucia Vanrell, Gloria González-Aseguinolaza, Africa Vales, Cristina Olagüe, Katherine A. High, Jesús Prieto, Federico Mingozzi, Irene Gil-Farina, Marianna Di Scala

Publikováno v: PLoS ONE; Vol 8
PLoS ONE, Vol 8, Iss 7, p e67748 (2013)
Dadun. Depósito Académico Digital de la Universidad de Navarra
instname
PLoS ONE

Recombinant adenoassociated viral vectors (rAAV) have proven to be excellent candidates for gene therapy clinical applications. Recent results showed that cellular immunity to AAV represents a major challenge facing the clinical use of systemic admin

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