Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Hepatocytes/drug effects"'
Autor:
Jean-Michel Fustin, Hao Wen Chen, Masao Doi, Hsu Wen Chao, Pei Yun Young, Hsien San Hou, Shu Hui Lin, Huatao Chen, Pei Chih King, Yen Lurk Lee, Yen Sung Huang, Hui Huang Lai, Heng Lin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, pp. 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, Lee, Y-L, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, pp. 645 . https://doi.org/10.1038/s41467-020-20572-8
Lin, H, Huang, Y-S, Fustin, J-M, Doi, M, Chen, H, Lai, H-H, Lin, S-H, Lee, Y-L, King, P-C, Hou, H-S, Chen, H-W, Young, P-Y & Chao, H-W 2021, ' Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver ', Nature Communications, vol. 12, no. 1, 645 . https://doi.org/10.1038/s41467-020-20572-8
Hepatocellular carcinoma (HCC) is the most predominant primary malignancy in the liver. Genotoxic and genetic models have revealed that HCC cells are derived from hepatocytes, but where the critical region for tumor foci emergence is and how this tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc4a90250a26229102d4437b41f7865a
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
https://doaj.org/article/2a6b0a8610cd4b32b27ac9dde0bc48ce
Publikováno v:
Archives of Toxicology. 93:3067-3098
Drug-induced liver injury (DILI) complicates safety assessment for new drugs and poses major threats to both patient health and drug development in the pharmaceutical industry. A number of human liver cell-based in vitro models combined with toxicoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f2bbf8ee49c1491affb3577c1e40f5
https://doi.org/10.1007/s00204-019-02585-5
https://doi.org/10.1007/s00204-019-02585-5
Autor:
Jens M. Kelm, S. Messner, T. M. de Kok, Jian Jiang, M.H.M. van Herwijnen, Danyel Jennen, J.C.S. Kleinjans
Publikováno v:
Toxicology Letters, 312, 34-44. Elsevier Ireland Ltd
Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues, a co-culture of primary human hepat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b284f6f67c1475aa6ddc29b7c7a153
https://doi.org/10.1016/j.toxlet.2019.05.004
https://doi.org/10.1016/j.toxlet.2019.05.004
Long Non-Coding RNAs Involved in Progression of Non-Alcoholic Fatty Liver Disease to Steatohepatitis
Autor:
Bart van de Sluis, Folkert Kuipers, Ronit Shiri-Sverdlov, Cisca Wijmenga, Jingyuan Fu, Glenn Marsman, Biljana Atanasovska, Sander S. Rensen, Sebo Withoff
Publikováno v:
Cells, 10, 8
Cells
Cells, Vol 10, Iss 1883, p 1883 (2021)
Volume 10
Issue 8
Cells, 10
Cells, 10(8):1883, 1-15. MDPI AG
Cells, 10(8):1883. Multidisciplinary Digital Publishing Institute (MDPI)
Cells
Cells, Vol 10, Iss 1883, p 1883 (2021)
Volume 10
Issue 8
Cells, 10
Cells, 10(8):1883, 1-15. MDPI AG
Cells, 10(8):1883. Multidisciplinary Digital Publishing Institute (MDPI)
Contains fulltext : 238435.pdf (Publisher’s version ) (Open Access) Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is characterized by different stages varying from benign fat accumulation to non-alcoholic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1148e54276777d14b2d8ee9bbae3478
https://repository.ubn.ru.nl/handle/2066/238435
https://repository.ubn.ru.nl/handle/2066/238435
Autor:
Jing Ma, Peixin Yang, Bin Gao, Robim Marcelino Rodrigues, Seonghwan Hwang, Haixia Cao, Dechun Feng, Ruixue Ren, Suthat Liangpunsakul, Yong He, Jian Sun, Mingjiang Xu, Tianyi Ren
Publikováno v:
JCI Insight
Alcohol-associated liver disease is a spectrum of liver disorders with histopathological changes ranging from simple steatosis to steatohepatitis, cirrhosis, and hepatocellular carcinoma. Recent data suggest that chronic-plus-binge ethanol intake ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adeef2c85a140e54ad04509355c9188
https://doi.org/10.1172/jci.insight.136496
https://doi.org/10.1172/jci.insight.136496
Autor:
Gökhan Ertaylan, Ralf Peeters, Kurt Driessens, Alexander Lukas, Daniel Lopatta, Danyel Jennen, Shauna D O'Donovan, Jelmer Neeven, Theo M. de Kok, Natal A. W. van Riel, Evgueni Smirnov, Florian Wimmenauer, Michael Lenz, Rachel Cavill, Tobias Stumm
Publikováno v:
PLoS ONE, 15(8). Public Library of Science
PLOS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE
PLoS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE, 15(8)
PLoS ONE 15 (2020) 8
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
PLOS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE
PLoS ONE, 15(8):e0236392. Public Library of Science
PLoS ONE, 15(8)
PLoS ONE 15 (2020) 8
PLoS ONE, Vol 15, Iss 8, p e0236392 (2020)
In clinical trials, animal and cell line models are often used to evaluate the potential toxic effects of a novel compound or candidate drug before progressing to human trials. However, relating the results of animal and in vitro model exposures to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab28b049df1eb0bf4886171aacfd7cb
https://pure.amc.nl/en/publications/use-of-deep-learning-methods-to-translate-druginduced-gene-expression-changes-from-rat-to-human-primary-hepatocytes(73c11227-9451-40b5-a199-15f21993acf5).html
https://pure.amc.nl/en/publications/use-of-deep-learning-methods-to-translate-druginduced-gene-expression-changes-from-rat-to-human-primary-hepatocytes(73c11227-9451-40b5-a199-15f21993acf5).html
Autor:
J.H.M. van Delft, R. Peters, A. Hecka, Karen Mathijs, Leen Timmermans, J. Weusten, Danyel Jennen, Sandra M.H. Claessen, Jian Jiang, Jos C. S. Kleinjans, T. M. de Kok
Publikováno v:
Toxicology and Applied Pharmacology, 332, 100-108. Elsevier Science
The mechanisms of idiosyncratic drug-induced hepatotoxicity remain largely unclear. It has demonstrated that the drug idiosyncrasy is potentiated in the context of inflammation and intracellular ceramides may play a role in this process.To study the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7be66a5219c191ebdce2868f94f4e3
https://doi.org/10.1016/j.taap.2017.07.014
https://doi.org/10.1016/j.taap.2017.07.014
Autor:
Sébastien Lhomme, Olivier Marion, Nicolas Carrere, Florence Abravanel, Marion Migueres, Nassim Kamar, Mélanie Pucelle, Pierre Delobel, Martine Dubois, Bertrand Suc, Mary Requena, Manon Nayrac, Jean-Marie Peron, Jacques Izopet
Publikováno v:
Gut
Gut, BMJ Publishing Group, 2020, 69 (5), pp.901-910. ⟨10.1136/gutjnl-2019-319004⟩
Gut, BMJ Publishing Group, 2020, 69 (5), pp.901-910. ⟨10.1136/gutjnl-2019-319004⟩
ObjectiveHepatitis E virus (HEV), one of the most common agent of acute hepatitis worldwide, is mainly transmitted enterically, via contaminated water for HEV genotypes 1 (HEV1) and HEV2, or by eating raw or undercooked infected meat for HEV genotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56835005e2457dc7227b0e4cfe93e33f
https://pubmed.ncbi.nlm.nih.gov/31915238
https://pubmed.ncbi.nlm.nih.gov/31915238
Publikováno v:
Biotechnichistochemistry : official publication of the Biological Stain Commission. 94(4)
Little is known about the pathogenesis of high fructose corn syrup (HFCS) induced hepatic toxicity. We investigated hepatic lesions induced by chronic HFCS consumption and the protective effects of alpha-lipoic acid (ALA) on liver pathology. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1957465347a09cd03070b68796843f96
https://pubmed.ncbi.nlm.nih.gov/30632398
https://pubmed.ncbi.nlm.nih.gov/30632398
Autor:
Agnese Restuccia, Peter Schemmer, Ralf Bartenschlager, Silke Bender, Stefan Seitz, Katrin Schöneweis, Florian A. Lempp, Pascal Mutz, Ronald Koschny, Thomas Tu, Jamie Frankish, Thomas F. Baumert, Bingqian Qu, Marco Binder, Stephan Urban, Katrin Hoffmann, Christopher Dächert, Philippe Metz, Benjamin Schusser, Georgios Polychronidis
Publikováno v:
Gastroenterology
Gastroenterology, 2018, 154 (6), pp.1791-1804. ⟨10.1053/j.gastro.2018.01.044⟩
Gastroenterology, 2018, 154 (6), pp.1791-1804. ⟨10.1053/j.gastro.2018.01.044⟩
Background & Aims Hepatitis C virus (HCV) infection is sensitive to interferon (IFN)-based therapy, whereas hepatitis B virus (HBV) infection is not. It is unclear whether HBV escapes detection by the IFN-mediated immune response or actively suppress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c88fea075a678a20fe2c4922271212c
https://hal.archives-ouvertes.fr/hal-02441618
https://hal.archives-ouvertes.fr/hal-02441618