Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Hepatocyte-like cell"'
Publikováno v:
Jichu yixue yu linchuang, Vol 43, Iss 7, Pp 1045-1052 (2023)
Objective To optimize the method of generating hepatocyte-like cells (HLCs) from pluripotent stem cells (PSCs)in vitro. Methods Considering the development of hepatocyte in vivo, a more efficient method was developed by optimizing biochemical factors
Externí odkaz:
https://doaj.org/article/84b3101c0e1046dfba41b748c8104439
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101395- (2024)
The liver exhibits remarkable regenerative capacity. However, the limited ability of primary human hepatocytes to proliferate in vitro, combined with a compromised regenerative capacity induced by pathological conditions in vivo, presents significant
Externí odkaz:
https://doaj.org/article/a2f7f1ad91264cc8b9b7b0647390d93c
Autor:
Yanchun Ma, Wenwen Sun, Lidong Zhao, Mingze Yao, Changxin Wu, Pengfei Su, Linhua Yang, Gang Wang
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2022)
Abstract Background Hemophilia B is a rare inherited genetic bleeding disorder caused by a deficiency or lack of coagulation factor IX, the gene for which (F9) is located on the X chromosome. Hemophilia B is currently incurable and the standard treat
Externí odkaz:
https://doaj.org/article/98f5b9af77da4bc98f5aa9e975b97949
Akademický článek
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Autor:
Siiri Suominen, Tinja Hyypijev, Mari Venäläinen, Alma Yrjänäinen, Hanna Vuorenpää, Mari Lehti-Polojärvi, Mikko Räsänen, Aku Seppänen, Jari Hyttinen, Susanna Miettinen, Katriina Aalto-Setälä, Leena E. Viiri
Publikováno v:
Cells, Vol 12, Iss 19, p 2368 (2023)
Induced pluripotent stem cell (iPSC) technology enables differentiation of human hepatocytes or hepatocyte-like cells (iPSC-HLCs). Advances in 3D culturing platforms enable the development of more in vivo-like liver models that recapitulate the compl
Externí odkaz:
https://doaj.org/article/c56c0b0a36cf45aeabc88d46db5d20d7
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102763- (2022)
Research in the field of hepatology is limited by the incomplete recapitulation of all major aspects of human hepatic metabolism in most established models. This restricts our ability to study the molecular mechanisms underlying hepatic diseases, and
Externí odkaz:
https://doaj.org/article/86b46189ec2e42d29c1cebb009f093da
Autor:
Jian Hou, Yan Long, Bo Hu, Shaojie Huang, Guangtao Xu, Tesheng Gao, Fenfang Wu, Yinxiong Li, Zhong-Kai Wu
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 4, Pp 1533-1543 (2018)
Background/Aims: Hepatocyte-like cells derived from human pluripotent stem cells could be an important cell source for hepatocyte transplantation. The present study investigated the effect of retaining mTeSR1 medium during hepatic differentiation on
Externí odkaz:
https://doaj.org/article/90bde15a7a4747f483293be3a03d181a
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 10, Iss , Pp 122-130 (2018)
Progress in gene editing research has been accelerated by utilizing engineered nucleases in combination with induced pluripotent stem cell (iPSC) technology. Here, we report transcription activator-like effector nuclease (TALEN)-mediated reincorporat
Externí odkaz:
https://doaj.org/article/5c25580fe484488fb2b78edcd83ed99d
Publikováno v:
In Vitro Cellular & Developmental Biology. Animal, 2004 Nov 01. 40(10), 318-330.
Externí odkaz:
https://www.jstor.org/stable/4295573
Autor:
Mostafa Kiamehr, Leena E. Viiri, Terhi Vihervaara, Kaisa M. Koistinen, Mika Hilvo, Kim Ekroos, Reijo Käkelä, Katriina Aalto-Setälä
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1141-1153 (2017)
Hepatocyte-like cells (HLCs) differentiated from human induced pluripotent stem cells (iPSCs) offer an alternative model to primary human hepatocytes to study lipid aberrations. However, the detailed lipid profile of HLCs is yet unknown. In the curre
Externí odkaz:
https://doaj.org/article/27d75dac246b442ab173278a2d2822ef