Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hepatitis C Virus NS3/4A Protease Inhibitors"'
Autor:
Anne Taylor, Charles J. Mcintyre, Christine Fandozzi, Carolyn McHale, Jillian DiMuzio, Steven Harper, Steven S. Carroll, Vincenzo Summa, Jeff Fritzen, Aileen Soriano, Marco Ferrara, Joseph J. Romano, David B. Olsen, Kevin Nguyen, Steven W. Ludmerer, Nigel J. Liverton, Robert Chase, Stuart Black, John W. Butcher, Kevin F. Gilbert, Qian Huang, Michael T. Rudd, Adam Gates, Paul J. Coleman, Marcello DiFilippo, Mark Stahlhut, Kimberly J. Bush, John Swestock, Nicole Trainor, Christine Burlein, Stephanie McClain, John A. McCauley, M. Katharine Holloway, Donald J. Graham
Publikováno v:
ChemMedChem. 10:727-735
With the goal of identifying inhibitors of hepatitis C virus (HCV) NS3/4a protease that are potent against a wide range of genotypes and clinically relevant mutant viruses, several subseries of macrocycles were investigated based on observations made
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e23e37fb44618a041512672388b2e3
https://doi.org/10.1002/cmdc.201402558
https://doi.org/10.1002/cmdc.201402558
Autor:
Vida Gorys, Peter W. White, Josée Bordeleau, Cédrickx Godbout, Jeff A. O'Meara, Michel Garneau, Benoît Moreau, Elisia Villemure, Mélissa Leblanc, Montse Llinas-Brunet
Publikováno v:
Journal of Medicinal Chemistry. 57:1770-1776
Given the emergence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhibitors, there is a need for new inhibitors with a higher barrier to resistance. We recently reported our rational approach to the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f50ec4abced1742906b01ff89a70abc
https://doi.org/10.1021/jm400121t
https://doi.org/10.1021/jm400121t
Autor:
Michael T. Rudd, John A. McCauley
Publikováno v:
Current opinion in pharmacology. 30
Hepatitis C virus (HCV) infection is a major health issue around the world and HCV NS3/4a protease inhibitors have been the focus of intensive research for the past 20 years. From the first identification of substrate-derived peptide inhibitors to th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfe58fa57b48d4df8b61ea47ccdfc39
https://pubmed.ncbi.nlm.nih.gov/27544488
https://pubmed.ncbi.nlm.nih.gov/27544488