Zobrazeno 1 - 10
of 18 494
pro vyhledávání: '"Hepatic Stellate Cell"'
Autor:
Ayana Fujiwara, Keisuke Takemura, Anna Tanaka, Misaki Matsumoto, Masato Katsuyama, Takeshi Okanoue, Kanji Yamaguchi, Yoshito Itoh, Kazumi Iwata, Kikuko Amagase, Atsushi Umemura
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Because hepatic stellate cells (HSCs) play a major role in fibrosis, we focused on HSCs as a potential target for the treatment of liver fibrosis. In this study, we attempted to identify drug candidates to inactivate HSCs and found that seve
Externí odkaz:
https://doaj.org/article/b3a0293e746b4e4aa4f6b1fa1200d07d
Autor:
Xuecui Yin, Lin Dong, Xiaohan Wang, Zhenzhen Qin, Yuying Ma, Xiaofei Ke, Ya Li, Qingde Wang, Yang Mi, Quanjun Lyu, Xia Xu, Pengyuan Zheng, Youcai Tang
Publikováno v:
Animal Models and Experimental Medicine, Vol 7, Iss 2, Pp 166-178 (2024)
Abstract Background Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases globally. Hepatic stellate cells (HSCs) are the major effector cells of liver fibrosis. HSCs contain abundant lipid droplets (LDs) in their
Externí odkaz:
https://doaj.org/article/819eb71873144d5eade6111c079560ce
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Liver fibrosis, as a consequence of chronic liver disease, involves the activation of hepatic stellate cell (HSC) caused by various chronic liver injuries. Emerging evidence suggests that activation of HSC during an inflammatory state can le
Externí odkaz:
https://doaj.org/article/b21704a104814240a7150abfa75f7c3e
Autor:
Lijun Chen, Yuqi Huang, Ning Zhang, Jingjing Qu, Yangxin Fang, Jiamin Fu, Yin Yuan, Qi Zhang, Hang Li, Zuoshi Wen, Li Yuan, Lu Chen, Zhenyu Xu, Yifei Li, Huadong Yan, Hiromi Izawa, Lanjuan Li, Charlie Xiang
Publikováno v:
MedComm, Vol 5, Iss 8, Pp n/a-n/a (2024)
Abstract Liver fibrosis can cause hepatitis B virus (HBV)‐associated hepatocellular carcinoma. Menstrual blood‐derived mesenchymal stem cells (MenSCs) can ameliorate liver fibrosis through paracrine. Single‐cell RNA sequencing (scRNA‐seq) may
Externí odkaz:
https://doaj.org/article/4947c98010b847b6abeebdc76fa25740
Publikováno v:
Waike lilun yu shijian, Vol 29, Iss 02, Pp 126-131 (2024)
The liver is the most common site of metastasis in patients with colorectal cancer(CRC). The liver microenvironment is a diverse assemblage of cells, which has their own unique biological characteristics and functions, supplemented by the interaction
Externí odkaz:
https://doaj.org/article/a222f7371f7d411191d467babd27b87b
Publikováno v:
Journal of the National Cancer Center, Vol 4, Iss 1, Pp 25-35 (2024)
Hepatic stellate cells (HSCs), a distinct category of non-parenchymal cells in the liver, are critical for liver homeostasis. In healthy livers, HSCs remain non-proliferative and quiescent. However, under conditions of acute or chronic liver damage,
Externí odkaz:
https://doaj.org/article/e8a48dd8b27d4d9c8e20070b7a8df46f
Autor:
Keiko Seino, Tomoyuki Nakano, Toshiaki Tanaka, Yasukazu Hozumi, Matthew K. Topham, Kaoru Goto, Ken Iseki
Publikováno v:
FEBS Open Bio, Vol 14, Iss 2, Pp 300-308 (2024)
Expression of α‐smooth muscle actin (αSMA) is constitutive in vascular smooth muscle cells, but is induced in nonmuscle cells such as hepatic stellate cells (HSCs). HSCs play important roles in both physiological homeostasis and pathological resp
Externí odkaz:
https://doaj.org/article/3068bee3ba404d47bbc2cb2ea859d866
Autor:
Quan Pan, Mingming Gao, DaMi Kim, Weiqi Ai, Wanbao Yang, Wen Jiang, Wesley Brashear, Yujiao Dai, Sha Li, Yuxiang Sun, Yajuan Qi, Shaodong Guo
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 1, Pp 41-58 (2024)
Background & Aims: The O-class of the forkhead transcription factor FoxO1 is a crucial factor mediating insulin→PI3K→Akt signaling and governs diverse cellular processes. However, the role of hepatocyte FoxO1 in liver fibrosis has not been well-e
Externí odkaz:
https://doaj.org/article/05764a4c864b4728a0e2a8d0155e6765
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Interferon Regulatory Factor 3 (IRF3) is a transcription factor that plays a crucial role in the innate immune response by recognizing and responding to foreign antigens. Recently, its roles in sterile conditions are being studied
Externí odkaz:
https://doaj.org/article/33090ef204054f3da42b26093e11c449
Progress of researches on inducing hepatic stellate cell ferroptosis for treatment of liver fibrosis
Autor:
SUN Lijie, HAO Dandan
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 1, Pp 108-113 (2024)
Emerging evidence suggests that ferroptosis, an iron-dependent form of regulated cell death, plays a critical role in the genesis of liver fibrosis through inducing hepatic stellate cell (HSC) ferroptosis to inhibit liver fibrosis or inducing hepatic
Externí odkaz:
https://doaj.org/article/c45a80f7bab942e8a0d98492853f10c9