Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Heparin biosynthesis"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 933-941 (2020)
Pharmaceutical heparin’s activity arises from a key high affinity and high selectivity antithrombin binding motif, which forms the basis for its use as an anticoagulant. The current problems with the supply of pig heparin raises the emphasis of und
Externí odkaz:
https://doaj.org/article/55e0e65822bf49e38c7209872ee1e9f8
Akademický článek
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Publikováno v:
Bioengineered. 8(5)
Heparin has been used clinically as an anti-coagulant for more than 100 y and the major source of this therapeutic is still animal tissues. Contamination issues in some batches of heparin over 10 y ago have highlighted the need to develop alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53f105bfd5eada1f4af315d070e7a1cd
https://pubmed.ncbi.nlm.nih.gov/28394734
https://pubmed.ncbi.nlm.nih.gov/28394734
Publikováno v:
Glycoconjugate Journal. 31:409-416
Heparin-antithrombin interaction is one of the most documented examples of heparin/protein complexes. The specific heparin sequence responsible for the binding corresponds to a pentasaccharide sequence with an internal 3-O-sulfated glucosamine residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80432a32fc1e54078dbf15da976734ce
https://doi.org/10.1007/s10719-014-9543-9
https://doi.org/10.1007/s10719-014-9543-9
Autor:
Ujjwal Bhaskar, Robert J. Linhardt, Fuming Zhang, Samantha Cheong, Onishi Akihiro, Zhenyu Wang, Jonathan S. Dordick, Jennifer Li
Publikováno v:
Journal of Biotechnology. 156:188-196
The chemical step in the chemoenzymatic synthesis of bioengineered heparin has been examined and optimized statistically using a response surface methodology. A four factor, two level full factorial design experiment and a three factor Box-Behnken de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc91c8c76627e96a8230c543ba9cc1da
https://doi.org/10.1016/j.jbiotec.2011.08.013
https://doi.org/10.1016/j.jbiotec.2011.08.013
Publikováno v:
Biotechnology Journal. 7:237-250
This review provides an overview of the properties, different biosynthetic machineries, and biotechnological production processes of four microbially derived glucuronic acid-based polysaccharides that are of interest for diverse biomedical purposes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a534372fc8defa0c6749c45e141e4e50
https://doi.org/10.1002/biot.201100242
https://doi.org/10.1002/biot.201100242
Publikováno v:
Molecules, Vol 23, Iss 2, p 390 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
The discovery of heparin in 1916 by Jay McLean, a medical student at Johns Hopkins University, not only provided a universal anticoagulant, but also laid the foundation for the discipline of hemostasis and thrombosis[...]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c1d1794b39329c847884dbaba93009
https://doi.org/10.3390/molecules23020390
https://doi.org/10.3390/molecules23020390
Publikováno v:
Glycoconjugate Journal. 13:995-1003
The synthesis of the disaccharides methyl 4-O-(2'/3'-O-sulfo-beta-D-glucopyranosyluronic acid)-2-amino-2-deoxy-alpha-D-glucopyranoside 3 and 4 as disodium salts is described. Allyl 4,6-O-benzylidene-alpha-D-glucopyranoside 6 was converted to trichlor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a56fd2823ed9eed5c2aaed2b165b24
https://doi.org/10.1007/bf01053195
https://doi.org/10.1007/bf01053195
Publikováno v:
Heparin-A Century of Progress ISBN: 9783642230554
The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their effects extracellularly by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e124ed49d389734e0a0cc8f57a24aa
https://doi.org/10.1007/978-3-642-23056-1_8
https://doi.org/10.1007/978-3-642-23056-1_8
Publikováno v:
Carbohydrate Polymers, 93(1), 38-47
Carbohydrate Polymers 93 (2013) 1
Carbohydrate Polymers 93 (2013) 1
Heparin and heparan sulfate belong to the glycosaminoglycan family. Heparin which is known as a powerful anticoagulant has been also described to have potential in therapeutic applications such as in the treatment against cancer and prevention of vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::813e94267161ab1d39e8ba0267318b10
https://pubmed.ncbi.nlm.nih.gov/23465899
https://pubmed.ncbi.nlm.nih.gov/23465899