The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication

Autor: Zhuang, Xiaodong, Magri, Andrea, Hill, Michelle, Lai, Alvina G., Kumar, Abhinav, Rambhatla, Srinivasa Bhargav, Donald, Claire L., Lopez-Clavijo, Andrea F., Rudge, Simon, Pinnick, Katherine, Chang, Wai Hoong, Wing, Peter A. C., Brown, Ryan, Qin, Ximing, Simmonds, Peter, Baumert, Thomas F., Ray, David, Loudon, Andrew, Balfe, Peter, Wakelam, Michael, Butterworth, Sam, Kohl, Alain, Jopling, Catherine L., Zitzmann, Nicole, McKeating, Jane A.

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-08299-7⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-08299-7⟩
Zhuang, X, Magri, A, Hill, M, Lai, A G, Kumar, A, Rambhatla, S B, Donald, C L, Lopez-Clavijo, A F, Rudge, S, Pinnick, K, Chang, W H, Wing, P A C, Brown, R, Qin, X, Simmonds, P, Baumert, T F, Ray, D, Loudon, A, Balfe, P, Wakelam, M, Butterworth, S, Kohl, A, Jopling, C L, Zitzmann, N & McKeating, J A 2019, ' The circadian clock components BMAL1 and REV-ERBα regulate flavivirus replication ', Nature Communications, vol. 10, no. 1, pp. 377 . https://doi.org/10.1038/s41467-019-08299-7

The circadian clock regulates immune responses to microbes and affects pathogen replication, but the underlying molecular mechanisms are not well understood. Here we demonstrate that the circadian components BMAL1 and REV-ERBα influence several step

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https://ora.ox.ac.uk/objects/uuid:ad095013-c658-4e13-936a-f46665e11105