Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Heonjong, Han"'
Autor:
Seung Woo Ryu, Ji‐Hee Yoon, Dong‐wook Kim, Beomman Han, Heonjong Han, Joohyun Han, Hane Lee, Go Hun Seo, Beom Hee Lee
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 12, Iss 3, Pp n/a-n/a (2024)
Abstract Background Tuberous sclerosis complex (TSC) is an autosomal dominant multisystem disorder, caused by a loss‐of‐function of either TSC1 or TSC2 gene. However, in 10%–15% TSC patients there is no pathogenic variant identified in either T
Externí odkaz:
https://doaj.org/article/33da8a59c3014aed91b50573d137a675
Autor:
Sujin Kang, Jaekyung Kim, Areum Park, Minsoo Koh, Wonji Shin, Gayoung Park, Taeyun A. Lee, Hyung Jin Kim, Heonjong Han, Yongbo Kim, Myung Kyung Choi, Jae Hyung Park, Eunhye Lee, Hyun-Soo Cho, Hyun Woo Park, Jae Hee Cheon, Sungwook Lee, Boyoun Park
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
The cortical actin cytoskeleton plays a role in maintaining intestinal epithelial integrity. Here the authors report that TRIM40, an E3 ligase, disrupts cortical actin formation and leads to loss of epithelial barrier integrity, and that genetic loss
Externí odkaz:
https://doaj.org/article/e495a621697c4ddeaf523b2d5d69b052
Autor:
Taeyun A. Lee, Heonjong Han, Ahsan Polash, Seok Keun Cho, Ji Won Lee, Eun A. Ra, Eunhye Lee, Areum Park, Sujin Kang, Junhee L. Choi, Ji Hyun Kim, Ji Eun Lee, Kyung-Won Min, Seong Wook Yang, Markus Hafner, Insuk Lee, Je-Hyun Yoon, Sungwook Lee, Boyoun Park
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The nucleolus is the traditional site for ribosomal RNA biogenesis. Here, the authors find that the nucleolus is a site of inflammatory pre-mRNA turnover and elucidated how immune homeostasis can be maintained by controlling inflammatory gene express
Externí odkaz:
https://doaj.org/article/3900adf1879d4f5d8d92fd2ebe8a5501
Autor:
Go Hun Seo, Hane Lee, Jungsul Lee, Heonjong Han, You Kyung Cho, Minji Kim, Yunha Choi, Jeongmin Choi, In Hee Choi, Seonkyeong Rhie, Kyu Young Chae, Yoo-Mi Kim, Chong Kun Cheon, Su Jin Kim, Jieun Lee, Eungu Kang, Jung Hye Byeon, Hee Joon Yu, Young-Lim Shin, Arum Oh, Woo Jin Kim, Mi-Sun Yum, Beom Hee Lee, Baik-Lin Eun
Publikováno v:
Molecular Medicine, Vol 28, Iss 1, Pp 1-15 (2022)
Abstract Background The diagnostic yield of whole-exome sequencing (WES) varies from 30%–50% among patients with mild to severe neurodevelopmental delay (NDD)/intellectual disability (ID). Routine retrospective reanalysis of undiagnosed patients ha
Externí odkaz:
https://doaj.org/article/4cf814bc387f4a96a50b40323f14c258
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100726- (2023)
Externí odkaz:
https://doaj.org/article/bcc5bc4019144360bbfa0bcd14f39a2c
Publikováno v:
Genetics in Medicine Open, Vol 1, Iss 1, Pp 100725- (2023)
Externí odkaz:
https://doaj.org/article/17f5cb16572a4c0d9fd837d4655df6e9
Autor:
Jae-Won Cho, Seyeon Park, Gamin Kim, Heonjong Han, Hyo Sup Shim, Sunhye Shin, Yong-Soo Bae, Seong Yong Park, Sang-Jun Ha, Insuk Lee, Hye Ryun Kim
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
EGFR mutant lung tumours do not respond favourably to immunotherapy. Here, using single cell sequencing, the authors find that tissue resident memory CD8+ T like cells are reduced in the immune landscape of EGFR mutant tumours in comparison to wild t
Externí odkaz:
https://doaj.org/article/af595a4fd0234e34ba5673acf338be2c
Autor:
Kyung Tae Lim, Jonghun Kim, Seon In Hwang, Ludi Zhang, Heonjong Han, Dasom Bae, Kee-Pyo Kim, Yi-Ping Hu, Hans R. Schöler, Insuk Lee, Lijian Hui, Dong Wook Han
Publikováno v:
Stem Cell Reports, Vol 10, Iss 5, Pp 1522-1536 (2018)
Summary: Disorders of the biliary epithelium, known as cholangiopathies, cause severe and irreversible liver diseases. The limited accessibility of bile duct precludes modeling of several cholangiocyte-mediated diseases. Therefore, novel approaches f
Externí odkaz:
https://doaj.org/article/a90ed3ab22de4fc298e212ffae0444ee
Autor:
Bruna Lucheze Freire, Thais Kataoka Homma, Antônio Marcondes Lerario, Go Hun Seo, Heonjong Han, Mariana Ferreira de Assis Funari, Nathalia Lisboa Gomes, Carla Rosemberg, Ana Cristina Victorino Krepischi, Gabriela de Andrade Vasques, Alexsandra Christianne Malaquias, Alexander Augusto de Lima Jorge
Publikováno v:
American Journal of Medical Genetics Part A. 188:2599-2604
Most infants born with very low birth weight (VLBW, birth weight 1500 g) show spontaneous catch-up growth in postnatal life. The reasons for the absence of catch-up growth are not entirely understood. We performed a comprehensive investigation of 52
Autor:
Hye Ryun Kim, Gamin Kim, Yong-Soo Bae, Insuk Lee, Seong Yong Park, Sang Jun Ha, Heonjong Han, Jae Won Cho, Seyeon Park, Hyo Sup Shim, Sunhye Shin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Patients with non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations exhibit an unfavorable response to PD-1 inhibitor through unclear mechanisms. Hypothesizing that EGFR mutations alter tumor-immune interactions, w