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pro vyhledávání: '"Heo, Muyoung"'
How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous non-functional interactions? Here we study this problem using a first-principle model of the cell whose phenotypic traits are directly dete
Externí odkaz:
http://arxiv.org/abs/1007.2668
Autor:
Heo, Muyoung, Shakhnovich, Eugene
Dramatic rise of mutators has been found to accompany adaptation of bacteria in response to many kinds of stress. Two views on the evolutionary origin of this phenomenon emerged: the pleiotropic hypothesis positing that it is a byproduct of environme
Externí odkaz:
http://arxiv.org/abs/0912.4726
The importance of mutator clones in the adaptive evolution of asexual populations is not fully understood. Here we address this problem by using an ab initio microscopic model of living cells, whose fitness is derived directly from their genomes usin
Externí odkaz:
http://arxiv.org/abs/0902.2404
Which factors govern the evolution of mutation rates and emergence of species? Here, we address this question using a first principles model of life where population dynamics of asexual organisms is coupled to molecular properties and interactions of
Externí odkaz:
http://arxiv.org/abs/0810.1765
How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of humoral immune response with explicitly defined interactions between Im
Externí odkaz:
http://arxiv.org/abs/0805.3841
Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a microscopic, protein-level, sequence-based model of immune system, with e
Externí odkaz:
http://arxiv.org/abs/0711.3456
Akademický článek
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Publikováno v:
In Ecological Modelling 24 June 2015 306:257-267
Publikováno v:
In Procedia Computer Science 2014 29:2515-2520
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2011 Mar 01. 108(10), 4258-4263.
Externí odkaz:
https://www.jstor.org/stable/41061094