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Discovery and SAR of Novel 2,3-Dihydroimidazo[1,2-c]quinazoline PI3K Inhibitors: Identification of Copanlisib (BAY 80-6946).

Autor: Scott WJ; Global Development, Global Program Management, Bayer HealthCare Pharmaceuticals Inc., Whippany, NJ, 07981, USA. william.scott@bayer.com., Hentemann MF; Former Bayer Research Center, West Haven, CT, 16516, USA., Rowley RB; Former Bayer Research Center, West Haven, CT, 16516, USA., Bull CO; Former Bayer Research Center, West Haven, CT, 16516, USA., Jenkins S; Former Bayer Research Center, West Haven, CT, 16516, USA., Bullion AM; Former Bayer Research Center, West Haven, CT, 16516, USA., Johnson J; Former Bayer Research Center, West Haven, CT, 16516, USA., Redman A; Former Bayer Research Center, West Haven, CT, 16516, USA., Robbins AH; Former Bayer Research Center, West Haven, CT, 16516, USA., Esler W; Former Bayer Research Center, West Haven, CT, 16516, USA., Fracasso RP; Former Bayer Research Center, West Haven, CT, 16516, USA., Garrison T; Former Bayer Research Center, West Haven, CT, 16516, USA., Hamilton M; Former Bayer Research Center, West Haven, CT, 16516, USA., Michels M; Global Drug Discovery, Project Management Drug Discovery, Bayer Pharma AG, 13353, Berlin, Germany., Wood JE; Former Bayer Research Center, West Haven, CT, 16516, USA., Wilkie DP; Former Bayer Research Center, West Haven, CT, 16516, USA., Xiao H; Former Bayer Research Center, West Haven, CT, 16516, USA., Levy J; Former Bayer Research Center, West Haven, CT, 16516, USA., Stasik E; Global Drug Discovery, TRG Oncology, Bayer Pharma AG, 13353, Berlin, Germany., Liu N; Global Drug Discovery, TRG Oncology, Bayer Pharma AG, 13353, Berlin, Germany., Schaefer M; Global Drug Discovery, Structural Biology, Bayer Pharma AG, 13353, Berlin, Germany., Brands M; Global Drug Discovery, Medicinal Chemistry Berlin, Bayer Pharma AG, 13353, Berlin, Germany., Lefranc J; Global Drug Discovery, Medicinal Chemistry Berlin, Bayer Pharma AG, 13353, Berlin, Germany. julien.lefranc@bayer.com.

Publikováno v: ChemMedChem [ChemMedChem] 2016 Jul 19; Vol. 11 (14), pp. 1517-30. Date of Electronic Publication: 2016 Jun 16.

Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).

Autor: Martínez-Botella G; AstraZeneca Infection Innovative Medicines, 35 Gatehouse Drive, Waltham, Massachusetts 02451, USA. gabriel@sagerx.com, Breen JN, Duffy JE, Dumas J, Geng B, Gowers IK, Green OM, Guler S, Hentemann MF, Hernandez-Juan FA, Joseph-McCarthy D, Kawatkar S, Larsen NA, Lazari O, Loch JT, Macritchie JA, McKenzie AR, Newman JV, Olivier NB, Otterson LG, Owens AP, Read J, Sheppard DW, Keating TA

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2012 Nov 26; Vol. 55 (22), pp. 10010-21. Date of Electronic Publication: 2012 Oct 24.