Synaptic phosphorylated alpha-synuclein in dementia with Lewy bodies

Autor: Colom-Cadena, M, Pegueroles, J, Herrmann, AG, Henstridge, CM, Munoz, L, Querol-Vilaseca, M, Martin-Paniello, C, Luque-Cabecerans, J, Clarimon, J, Belbin, O, Nunez-Llaves, R, Blesa, R, Smith, C, McKenzie, CA, Frosch, MP, Roe, A, Fortea, J, Andilla, J, Loza-Alvarez, P, Gelpi, E, Hyman, BT, Spires-Jones, TL, Lleo, A

Publikováno v: BRAIN
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
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Synaptic loss occurs early in dementia with Lewy bodies (DLB), but its relationship to alpha-synuclein pathology remains unclear. Using array tomography microscopy, Colom-Cadena et al. reveal small phosphorylated alpha-synuclein aggregates at synapti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::e5d7b438bdc0b50a7fe415798d1c5972
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4135

Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and ‘cannabinoid-like’ receptors in small arteries

Autor: Daly, CJ, Ross, RA, Whyte, J, Henstridge, CM, Irving, AJ, McGrath, JC

Pharmacological analysis of synergism or functional antagonism between different receptors commonly assumes that interacting receptors are located in the same cells. We have now investigated the distribution of alpha-adrenoceptors, beta-adrenoceptors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a36b8028efa5bd5d56a8f362d4f5bbfe
https://europepmc.org/articles/PMC2829204/

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer's disease via MFG-E8.

Autor: Tzioras M; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Daniels MJD; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Davies C; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Baxter P; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., King D; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., McKay S; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Varga B; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Popovic K; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Hernandez M; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Stevenson AJ; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Barrington J; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Drinkwater E; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Borella J; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Holloway RK; MRC Centre for Reproductive Health, the University of Edinburgh, Edinburgh EH16 4TJ, UK., Tulloch J; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Moss J; MRC Centre for Reproductive Health, the University of Edinburgh, Edinburgh EH16 4TJ, UK; The Roslin Institute, the Royal (Dick) School of Veterinary Studies, the University of Edinburgh, Edinburgh EH25 9RG, UK., Latta C; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Kandasamy J; Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK., Sokol D; Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK., Smith C; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh EH16 4SB, UK., Miron VE; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; MRC Centre for Reproductive Health, the University of Edinburgh, Edinburgh EH16 4TJ, UK; Barlo Multiple Sclerosis Centre at St. Michael's Hospital, Keenan Research Centre for Biomedical Science, Toronto, ON M5B 1T8, Canada., Káradóttir RT; Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UK., Hardingham GE; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK., Henstridge CM; Division of Systems Medicine, School of Medicine, University of Dundee, Dundee DD1 9SY, UK., Brennan PM; Department of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA, UK; Centre for Clinical Brain Sciences, the University of Edinburgh, Edinburgh EH16 4SB, UK., McColl BW; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK. Electronic address: barry.mccoll@ed.ac.uk., Spires-Jones TL; UK Dementia Research Institute, the University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Discovery Brain Sciences, the University of Edinburgh, Edinburgh EH8 9JZ, UK. Electronic address: tara.spires-jones@ed.ac.uk.

Publikováno v: Cell reports. Medicine [Cell Rep Med] 2023 Sep 19; Vol. 4 (9), pp. 101175. Date of Electronic Publication: 2023 Aug 30.

Synaptic resilience is associated with maintained cognition during ageing.

Autor: King D; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Holt K; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Toombs J; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., He X; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Dando O; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Okely JA; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Tzioras M; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Rose J; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Gunn C; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Correia A; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Montero C; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., McAlister H; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Tulloch J; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK., Lamont D; FingerPrints Proteomics Facility, School of Life Sciences, University of Dundee, Dundee, UK., Taylor AM; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Harris SE; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Redmond P; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Cox SR; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Henstridge CM; Systems Medicine, School of Medicine, University of Dundee, Dundee, UK., Deary IJ; Lothian Birth Cohorts, Department of Psychology, University of Edinburgh, Edinburgh, UK., Smith C; Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK., Spires-Jones TL; UK Dementia Research Institute and Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, UK.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Jun; Vol. 19 (6), pp. 2560-2574. Date of Electronic Publication: 2022 Dec 22.

Array tomography: 15 years of synaptic analysis.

Autor: Sanchez Avila A; Euan Macdonald Centre for Motor Neuron Disease, Edinburgh, UK.; Division of Cellular and Systems Medicine, University of Dundee, Dundee, UK., Henstridge CM; Euan Macdonald Centre for Motor Neuron Disease, Edinburgh, UK.; Division of Cellular and Systems Medicine, University of Dundee, Dundee, UK.

Publikováno v: Neuronal signaling [Neuronal Signal] 2022 Sep 23; Vol. 6 (3), pp. NS20220013. Date of Electronic Publication: 2022 Sep 23 (Print Publication: 2022).