Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Henryk Szmacinski"'
Autor:
Kavita R. Hegde, Krishanu Ray, Henryk Szmacinski, Sharon Sorto, Adam C. Puche, Imre Lengyel, Richard B. Thompson
Publikováno v:
Sensors, Vol 23, Iss 14, p 6626 (2023)
Deposition of calcium-containing minerals such as hydroxyapatite and whitlockite in the subretinal pigment epithelial (sub-RPE) space of the retina is linked to the development of and progression to the end-stage of age-related macular degeneration (
Externí odkaz:
https://doaj.org/article/8d5c1d63f5b74fae952bad806e1759fd
Autor:
Kavita R. Hegde, Adam C. Puche, Henryk Szmacinski, Kristina Fuller, Krishanu Ray, Nikita Patel, Imre Lengyel, Richard B. Thompson
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6421 (2023)
We have shown that all sub-retinal pigment epithelial (sub-RPE) deposits examined contain calcium phosphate minerals: hydroxyapatite (HAP), whitlockite (Wht), or both. These typically take the form of ca. 1 μm diameter spherules or >10 μm nodules a
Externí odkaz:
https://doaj.org/article/f8b53ab52cbb45c588ca3394f2fa4680
A Decoy Peptide that Disrupts TIRAP Recruitment to TLRs Is Protective in a Murine Model of Influenza
Autor:
Wenji Piao, Kari Ann Shirey, Lisa W. Ru, Wendy Lai, Henryk Szmacinski, Greg A. Snyder, Eric J. Sundberg, Joseph R. Lakowicz, Stefanie N. Vogel, Vladimir Y. Toshchakov
Publikováno v:
Cell Reports, Vol 11, Iss 12, Pp 1941-1952 (2015)
Toll-like receptors (TLRs) activate distinct, yet overlapping sets of signaling molecules, leading to inflammatory responses to pathogens. Toll/interleukin-1 receptor (TIR) domains, present in all TLRs and TLR adapters, mediate protein interactions d
Externí odkaz:
https://doaj.org/article/63d2963337ed483eb598fd123302073d
Autor:
Artur Javmen, Jun Zou, Shreeram C. Nallar, Henryk Szmacinski, Joseph R. Lakowicz, Andrew T. Gewirtz, Vladimir Y. Toshchakov
Publikováno v:
The Journal of Immunology. 210:1419-1427
TLR5, which is activated by flagellin, plays an important role in initiating immune response to a broad spectrum of motile bacterial pathogens. TLRs induce intracellular signaling via dimerization of their TIR domains followed by adapter recruitment
Publikováno v:
J Leukoc Biol
TLRs sense a broad range of microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/interleukin-1R homology (TIR) domain to initiate intracellular signaling. The activated TLRs dimerize their
Autor:
Joseph R. Lakowicz, Henryk Szmacinski
Publikováno v:
Sens Actuators B Chem
We describe the possibility of measuring sodium and potassium at the concentrations present in whole blood using lifetime-based sensing and phase-modulation fluorometry. The probe SBFO was shown to display changes in phase or modulation at sodium con
Publikováno v:
Sens Actuators B Chem
The ability to measure all the electrolyte concentrations in tears would be valuable in ophthalmology for research and diagnosis of dry eye disease (DED) and other ocular pathologies. However, tear samples are difficult to collect and analyze because
Publikováno v:
Anal Biochem
Rapid and non-invasive measurement of hydration status is medically important because even mild levels of dehydration can have a significant impact on physical and cognitive performance. Despite the potential value of determining whole-body hydration
Autor:
Adam C. Puche, Kavita R. Hegde, Hui-Hui Zeng, Richard B. Thompson, Henryk Szmacinski, Katayoun Eslami, Imre Lengyel
Publikováno v:
Szmacinski, H, Hegde, K, Zeng, H-H, Eslami, K, Puche, A C, Lengyel, I & Thompson, R B 2020, ' Imaging hydroxyapatite in sub-retinal pigment epithelial deposits by fluorescence lifetime imaging microscopy with tetracycline staining ', JOURNAL OF BIOMEDICAL OPTICS, vol. 25, no. 4 . https://doi.org/10.1117/1.JBO.25.4.047001
Journal of Biomedical Optics
Journal of Biomedical Optics
SIGNIFICANCE: Recent evidence suggests that hydroxyapatite (HAP) in sub-retinal pigment epithelial (sub-RPE) deposits in aged human eyes may act to nucleate and contribute to their growth to clinically detectable size. Sub-RPE deposits such as drusen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba4cce3bcb989b8f58b1bd1a6c51be5e
https://pure.qub.ac.uk/en/publications/imaging-hydroxyapatite-in-subretinal-pigment-epithelial-deposits-by-fluorescence-lifetime-imaging-microscopy-with-tetracycline-staining(7e2f315f-e395-41b5-ab70-7b2ad8931a7a).html
https://pure.qub.ac.uk/en/publications/imaging-hydroxyapatite-in-subretinal-pigment-epithelial-deposits-by-fluorescence-lifetime-imaging-microscopy-with-tetracycline-staining(7e2f315f-e395-41b5-ab70-7b2ad8931a7a).html
Autor:
Joseph R. Lakowicz, Henryk Szmacinski
Publikováno v:
Applied spectroscopy. 53(12)
We describe a method to correct for background fluorescence and to measure the intensity of long-lifetime probes using phase-modulation fluorometry. The theoretically predicted and simulated data were supported by two experiments. The fractional cont