Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Henryk Dudek"'
Autor:
Nathan T Morrell, Philipp Leucht, Ludan Zhao, Jae-Beom Kim, Derk ten Berge, Karthik Ponnusamy, A Lyonel Carre, Henryk Dudek, Marie Zachlederova, Michael McElhaney, Shirley Brunton, Janet Gunzner, Marinella Callow, Paul Polakis, Mike Costa, Xiaoyan M Zhang, Jill A Helms, Roel Nusse
Publikováno v:
PLoS ONE, Vol 3, Iss 8, p e2930 (2008)
Wnt signals exercise strong cell-biological and regenerative effects of considerable therapeutic value. There are, however, no specific Wnt agonists and no method for in vivo delivery of purified Wnt proteins. Wnts contain lipid adducts that are requ
Externí odkaz:
https://doaj.org/article/9d6786461d08499396af9c7a5f3c0bb3
Autor:
Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh
S1: RNAi mediated dose dependent mRNA silencing in human CRC xenografts. S2: Biodistribution and informal tolerability of DCR-BCAT in wild type mice. S3: Trametinib efficacy in human CRCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e28d90ca750648bef299d417402b86c
https://doi.org/10.1158/1535-7163.22510105.v1
https://doi.org/10.1158/1535-7163.22510105.v1
Autor:
Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh
Legends for supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f178480014a1d8c607ff17dccd562c
https://doi.org/10.1158/1535-7163.22510102.v1
https://doi.org/10.1158/1535-7163.22510102.v1
Autor:
Marc T. Abrams, Bob D. Brown, Weimin Wang, Henryk Dudek, Chengjung Lai, Wendy A. Cyr, Girish R. Chopda, Martin L. Koser, Kevin P. Craig, Xue Shui, Shanthi Ganesh
Colorectal carcinomas harbor well-defined genetic abnormalities, including aberrant activation of Wnt/β-catenin and MAPK pathways, often simultaneously. Although the MAPK pathway can be targeted using potent small-molecule drugs, including BRAF and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35d42d3262376dee76a9cd215ccebec
https://doi.org/10.1158/1535-7163.c.6539509
https://doi.org/10.1158/1535-7163.c.6539509
Autor:
Marc T. Abrams, Bob D. Brown, Weimin Wang, Satdarshan P. Monga, Henryk Dudek, Chengjung Lai, Kevin Craig, Zakir Siddiquee, Edmond Chipumuro, Purva Pandya, Dongyu Chen, Bo Ying, Xue Shui, Junyan Tao, Girish R. Chopda, Wendy A. Cyr, Martin L. Koser, Shanthi Ganesh
supplemental figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada8e18b3ca6e7a0cc20420f69c75b4d
https://doi.org/10.1158/1535-7163.22503670.v1
https://doi.org/10.1158/1535-7163.22503670.v1
Autor:
Marc T. Abrams, Bob D. Brown, Weimin Wang, Satdarshan P. Monga, Henryk Dudek, Chengjung Lai, Kevin Craig, Zakir Siddiquee, Edmond Chipumuro, Purva Pandya, Dongyu Chen, Bo Ying, Xue Shui, Junyan Tao, Girish R. Chopda, Wendy A. Cyr, Martin L. Koser, Shanthi Ganesh
Figure S1. Components of EnCore-A; Figure S2. Silencing of CTNNB1 mRNA after single-dose or multiple-dose regimens; Figure S3: Comparable activity achieved with a payload with 2'F modifications; Figure S4. Tumor growth inhibition in multiple subcutan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39592eed3dd0b7ac2a00b31300c73a8c
https://doi.org/10.1158/1535-7163.22503673
https://doi.org/10.1158/1535-7163.22503673
Publikováno v:
Postępy Psychiatrii i Neurologii. 27:232-246
Autor:
David R. Tomlinson, Jean Dominique Delcroix, Renee I. Shapiro, Rigel Ranciato, Jason D. Freshwater, Frederick R. Taylor, Monica L. Burgers, Andrew P. Mizisin, Thomas Engber, Nigel A. Calcutt, Henryk Dudek, Alicia Middlemas, Alphonse Galdes, Karen L. Allendoerfer, Lee L. Rubin, Kathy Strauch
Publikováno v:
Journal of Clinical Investigation. 111:507-514
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role i
Autor:
Sandeep Robert Datta, Xu Tao, Shane C. Masters, Michael E. Greenberg, Yukiko Gotoh, Henryk Dudek, Haian Fu
Publikováno v:
Cell. 91:231-241
Growth factors can promote cell survival by activating the phosphatidylinositide-3′-OH kinase and its downstream target, the serine-threonine kinase Akt. However, the mechanism by which Akt functions to promote survival is not understood. We show t
Autor:
Morris J. Birnbaum, Thomas F. Franke, Henryk Dudek, Rosalind A. Segal, Michael E. Greenberg, Ryoji Yao, David R. Kaplan, Sandeep Robert Datta, Geoffrey M. Cooper
Publikováno v:
Science. 275:661-665
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine