Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Henry W B, Johnson"'
Autor:
Tony Muchamuel, R. Andrea Fan, Janet L. Anderl, Darrin J. Bomba, Henry W. B. Johnson, Eric Lowe, Brian B. Tuch, Dustin L. McMinn, Beatriz Millare, Christopher J. Kirk
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Zetomipzomib (KZR-616) is a selective inhibitor of the immunoproteasome currently undergoing clinical investigation in autoimmune disorders. Here, we characterized KZR-616 in vitro and in vivo using multiplexed cytokine analysis, lymphocyte activatio
Externí odkaz:
https://doaj.org/article/b8472904a1e148a78a2945fec4d80181
Autor:
Jun Li, Shaobo Hu, Henry W B Johnson, Christopher J Kirk, Peng Xian, Yanping Song, Yuan Li, Nan Liu, Marcus Groettrup, Michael Basler
Publikováno v:
Cardiovascular Research. 119:1030-1045
The loss of vascular wall cells in allotransplanted arteries is the initial event leading to transplant arteriosclerosis (TA) and ensuing loss of allograft function. Pharmacological agents able to prevent TA are currently lacking. We previously showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a30bb611e747a9bebc2c1012383841f
https://doi.org/10.1093/cvr/cvac181
https://doi.org/10.1093/cvr/cvac181
Autor:
Erin Bradley, Lisa M. Kelly, Janet L. Anderl, Eric Lowe, David C. Moebius, Jeffrey Jones, Shirin Arastu-Kapur, Christopher J. Kirk, Henry W. B. Johnson, John Bui, Zhengping Wang, Dustin McMinn, Tony Muchamuel
Publikováno v:
ACS Medicinal Chemistry Letters. 8:413-417
Building upon the success of bortezomib (VELCADE) and carfilzomib (KYPROLIS), the design of a next generation of inhibitors targeting specific subunits within the immunoproteasome is of interest for the treatment of autoimmune disease. There are thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6baf150fa245ff729c9b833768c2ac19
https://doi.org/10.1021/acsmedchemlett.6b00496
https://doi.org/10.1021/acsmedchemlett.6b00496
Autor:
Henry W B, Johnson, Eric, Lowe, Janet L, Anderl, Andrea, Fan, Tony, Muchamuel, Simeon, Bowers, David C, Moebius, Christopher, Kirk, Dustin L, McMinn
Publikováno v:
Journal of medicinal chemistry. 61(24)
Selective immunoproteasome inhibition is a promising approach for treating autoimmune disorders, but optimal proteolytic active site subunit inhibition profiles remain unknown. We reveal here our design of peptide epoxyketone-based selective low mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::35428405c924423ae1704f80a06959ee
https://pubmed.ncbi.nlm.nih.gov/30380863
https://pubmed.ncbi.nlm.nih.gov/30380863
Publikováno v:
Chemistry - A European Journal. 12:1747-1753
The preceding manuscript detailed our synthesis of the gambierol A-C and F-H ring precursors. Reported herein is a description of the coupling of the two precursors and the conversion of the coupled material into gambierol. Coupling of the subunits i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4415b1766e4018a16b1c02e9669e6a70
https://doi.org/10.1002/chem.200500994
https://doi.org/10.1002/chem.200500994
Publikováno v:
Tetrahedron. 58:1997-2009
This manuscript describes the synthesis of fused polycyclic ethers from the coupling of C-glycoside forming reactions with ring closing metathesis and acid mediated annulation reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa936cfe9be112834cd51a13dfa59ed5
https://doi.org/10.1016/s0040-4020(02)00057-1
https://doi.org/10.1016/s0040-4020(02)00057-1
Publikováno v:
ChemInform. 33
This manuscript describes the synthesis of fused polycyclic ethers from the coupling of C-glycoside forming reactions with ring closing metathesis and acid mediated annulation reactions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f7dd57ae3a3c851b6e289e9473c7c63
https://doi.org/10.1002/chin.200230259
https://doi.org/10.1002/chin.200230259
Autor:
Henry W. B. Johnson, Dirk J. Snyders, Jan Tytgat, Ivan Kopljar, Jon D. Rainier, Alain J. Labro, Eva Cuypers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Gambierol is a marine polycyclic ether toxin belonging to the group of ciguatera toxins. It does not activate voltage-gated sodium channels (VGSCs) but inhibits Kv1 potassium channels by an unknown mechanism. While testing whether Kv2, Kv3, and Kv4 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec230487a59784e4781344a812b1ed0e
https://pubmed.ncbi.nlm.nih.gov/19482941
https://pubmed.ncbi.nlm.nih.gov/19482941
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 323(1)
The marine toxin gambierol, a polyether ladder toxin derived from the marine dinoflagellate Gambierdiscus toxicus , was evaluated for interaction with voltage-gated sodium channels (VGSCs) in cerebellar granule neuron (CGN) cultures. At concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763613eb7b6055694441710a3e8bcb89
https://pubmed.ncbi.nlm.nih.gov/17609421
https://pubmed.ncbi.nlm.nih.gov/17609421
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 12(6)
Gambierol, a representative of the marine ladder toxin family, consists of eight ether rings, 18 stereocenters, and two challenging pyranyl rings having methyl groups that are in a 1,3-diaxial orientation to one another. Herein we describe the genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4699f6884be93a6fbeb086499e9f0354
https://pubmed.ncbi.nlm.nih.gov/16331718
https://pubmed.ncbi.nlm.nih.gov/16331718