Výsledky vyhledávání

Manganese complexes with a lengthy o -xylylene cross-bridged cyclam ligand: synthesis, characterization and catalytic hydrogen abstraction by dioxygen activation

Autor: Guochuan Yin, David Johnathan Kitko, Daryle H. Busch, George Douglas Ii Hiler, William Michael Scheper, Henry T. He, John David Carter, Victor W. Day

Publikováno v: Journal of Coordination Chemistry. 61:45-59

Two ultra rigid, o-xylylene cross-bridged macrobicyclic ligands, 1,10,13,19-tetraazatricyclo[8.6.6.03,8]docosa-3,5,7-triene (H2XBC), and 13,19-dimethyl-1,10,13,19-tetraazatricyclo[8.6.6.03,8]docosa-3,5,7-triene (Me2XBC), have been synthesized and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13479fd26e32bd227a8f4afe95e89080
https://doi.org/10.1080/00958970701730331

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Synthesis and chemical stability of a disulfide bond in a model cyclic pentapeptide: Cyclo(1,4)‐Cys‐Gly‐Phe‐Cys‐Gly‐OH

Autor: Jiaher Tian, Todd D. Williams, Lidia Kupczyk-Subotkowska, R.Neslihan Gürsoy, Teruna J. Siahaan, Henry T. He

Publikováno v: Journal of Pharmaceutical Sciences. 95:2222-2234

Many cyclic peptides are formed using a disulfide bond to increase their conformational rigidity; this provides receptor selectivity and increased potency. However, degradation of the disulfide bond in formulation can lead to a loss of structural sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8327da319ca3aaa3b69ee6876226228
https://doi.org/10.1002/jps.20701

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Synthesis and comparison of physicochemical, transport, and antithrombic properties of a cyclic prodrug and the parent RGD peptidomimetic

Autor: Teruna J. Siahaan, Henry T. He, Christine R. Xu, Xiaoping Song

Publikováno v: Tetrahedron. 59:2861-2869

Cyclic prodrug 1 was derived from RGD peptidomimetic 2 by linking the amino and carboxylic acid groups via an (acyloxy)alkoxy linker. The formation of a cyclic prodrug can transiently alter the physicochemical properties of the RGD peptidomimetic. Cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::993d45e8ef629e4118481a79db547b2a
https://doi.org/10.1016/s0040-4020(03)00333-8

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Synthesis of Cyclic Prodrugs of Aggrastat and Its Analogue with a Modified Phenylpropionic Acid Linker

Autor: Xiaoping Song, Teruna J. Siahaan, Henry T. He

Publikováno v: Organic Letters. 4:549-552

[structure: see text] The objective of this work was to synthesize cyclic prodrugs 1a and 1b from Aggrastat 2a and its analogue 2b, respectively, to improve their membrane permeation. Cyclic prodrugs 1a and 1b were formed using an ester bond between

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414391a3c3bd9a15ca9611e97e3163c1
https://doi.org/10.1021/ol010282n

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Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation

Autor: Christine R. Xu, Teruna J. Siahaan, Henry T. He, Xiaoping Song

Publikováno v: Bioorganic chemistry. 30(4)

The objective of this work was to synthesize cyclic prodrug 2 derived from the parent RGD peptidomimetic 1 and to evaluate its chemical and enzymatic stabilities and antithrombic activity. Cyclic prodrug 2 was formed to improve the cell membrane perm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a6c5ec1e2e8ad3d942dde548c2e1d48
https://pubmed.ncbi.nlm.nih.gov/12392707

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